Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/18 16:22:47」(JST)

English Journal

Naito Y, Yoshikawa T.SourceDepartment of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan. ynaito@koto.kpu-m.ac.jp
Expert review of gastroenterology & hepatology.Expert Rev Gastroenterol Hepatol.2010 Jun;4(3):261-70.
Rebamipide, a gastroprotective drug, was developed in Japan and was proven to be superior to cetraxate, the former most prescribed drug of the same category, in 1989 in the treatment for gastric ulcers. The initially discovered basic mechanisms of action of rebamipide included its action as a prosta
PMID 20528113

Sugimori S, Watanabe T, Arakawa T.SourceDepartment of Gastroenterology, Osaka City University Medical School.
Nihon rinsho. Japanese journal of clinical medicine.Nihon Rinsho.2007 Oct 28;65 Suppl 8:193-7.
PMID 18074538

中村誠宏,森川敏生,加藤泰世,李寧,長友暁史,池桂花,大串輝樹,浅尾恭伸,松田久司,吉川雅之
天然有機化合物討論会講演要旨集 (48), 535-540, 2006-09-15
… Theasaponins A_2 and E_2 showed inhibitory effects on ethanol-induced gastric mucosal lesions in rat, and their effects were stronger than that of reference compound, cetraxate hydrocholoride. …
NAID 110006682710

Comparison of the Effects of Cytoprotective Drugs on Human Plasma Adrenocorticotropic Hormone and Cortisol Levels with Continual Stress Exposure(Pharmacology)

Katagiri Fumihiko,Shiga Toru,Sato Yuhki [他],INOUE Shin,ITOH Hiroki,TAKEYAMA Masaharu
Biological & pharmaceutical bulletin 28(11), 2146-2148, 2005-11-01
… Cetraxate hydrochloride (cetraxate), ecabet sodium (ecabet), and sulpiride, which are cytoprotective drugs, have been used to treat peptic ulcers and acute or chronic gastritis. … We examined the effects of cetraxate, ecabet and sulpiride on the plasma levels of ACTH and cortisol under stress conditions by repetitive blood sampling. … A single dose of cetraxate had no effect on plasma ACTH-IS and cortisol levels. …
NAID 10016783833

Comparison of the Effects of Cetraxate and its Major Metabolite on Human Plasma Gastrin, Somatostatin, Calcitonine Gene-Related Peptide and Substance P in Human Plasma

Katagiri Fumihiko,Inoue Shin,Sato Yuhki [他],Itoh Hiroki,Takeyama Masaharu
Journal of health science 51(2), 257-262, 2005-04-01
… Cetraxate hydrochloride (cetraxate), an antiulcer drug, produces a dose related increase in mucosal blood flow. … We have reported that cetraxate increases plasma calcitonin gene-related peptide (CGRP) and substance P in healthy human subjects (J. … Cetraxate is rapidly metabolized to tranexamic acid in plasma. …
NAID 110003666064

リンク元	「セトラキサート」
拡張検索	「cetraxate hydrochloride」

Cetraxate
Systematic (IUPAC) name
	3-[4-[4-(aminomethyl)cyclohexanecarbonyl]oxyphenyl]propanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	34675-84-8
ATC code	None
PubChem	CID 2680
ChemSpider	2579
UNII	5VPA8CPF0N
KEGG	D07663
ChEMBL	CHEMBL502896
Chemical data
Formula	C17H23NO4
Mol. mass	305.36 g/mol
	SMILES O=C(O)CCc2ccc(OC(=O)C1CCC(CN)CC1)cc2;