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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/23 10:24:50」(JST)
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Ceruletide
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| Systematic (IUPAC) name |
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(3S)-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}-3-[(2S)-2-[(2S)-2-{2-[(3R)-2-[(2S)-2-[(2S)-2-[(2S)-4-carbamoyl-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}butanamido]-3-carboxypropanamido]-3-[4-(sulfooxy)phenyl]propanamido]-3-hydroxybutanamido]acetamido}-3-(1H-indol-3-yl)propanamido]-4-(methylsulfanyl)butanamido]propanoic acid
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| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| Identifiers |
| CAS Number |
17650-98-5 Y |
| ATC code |
V04CC04 (WHO) |
| PubChem |
CID 16219178 |
| DrugBank |
DB00403 N |
| ChemSpider |
147304 N |
| UNII |
888Y08971B N |
| KEGG |
D03442 N |
| ChEMBL |
CHEMBL1201355 N |
| Chemical data |
| Formula |
C58H73N13O21S2 |
| Molar mass |
1352.40 g/mol |
| NY (what is this?) (verify) |
Ceruletide (INN), also known as cerulein or caerulein, is a ten amino acid oligopeptide that stimulates smooth muscle and increases digestive secretions. Ceruletide is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction. It is used to induce pancreatitis in experimental animal models.
The tree frog
Litoria caerulae, formerly named
Hyla caerulae.
Ceruletide was discovered and its structure elucidated in 1967 by Australian and Italian scientists from dried skins of the Australian green tree frog (Litoria caerulea, formerly Hyla caerulea). Its amino acid sequence is Pglu-Gln-Asp-Tyr[SO3H]-Thr-Gly-Trp-Met-Asp-Phe-NH2.[1][2]
Induction of pancreatitis
Ceruletide upregulates pancreatic acinar cell intercellular adhesion molecule-1 (ICAM-1) proteins through intracellular upregulation of NF-κB. Surface ICAM-1 in turn promotes neutrophil adhesion onto acinar cells enhancing pancreatic inflammation.[3] In addition to promoting the inflammatory cell reaction to acinar cells, ceruletide induces pancreatitis through dysregulation of digestive enzyme production and cytoplasmic vacuolization, leading to acinar cell death and pancreatic edema. Ceruletide also activates NADPH oxidase, a source of reactive oxygen species contributing to inflammation, as well as the Janus kinase/signal transducer, another inflammation inducer.[4]
See also
References
- ^ A. Anastasi; V. Erspamer; R. Endean (1967). "Isolation and structure of caerulein, an active decapeptide from the skin of Hyla caerulea". Experentia 23 (9): 699–700. doi:10.1007/BF02154119.
- ^ G. De Caro; R. Endean; V. Esparmer; M. Roseghini (1968). "Occurrence of caerulein in extracts of the skin of Hyla caerulea and other Australian hylids". Br J of Pharmac Chemother 33 (1): 48–58. PMC 1570274. PMID 5660165.
- ^ V. Zaninovic; A. S. Gukovskaya; I. Gukovsky; M. Mouria; S. J. Pandol (2000). "Cerulein upregulates ICAM-1 in pancreatic acinar cells, which mediates neutrophil adhesion to these cells" (PDF). Am J Physiol Gastrointest Liver Physiol 279 (4): G666–676. PMID 11005752.
- ^ H. Kim (2008). "Cerulein Pancreatitis: Oxidative Stress, Inflammation, and Apoptosis". Gut and liver 167 (2): 74–80. doi:10.5009/gnl.2008.2.2.74. PMC 2871591. PMID 20485614.
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Diagnostic agents (V04)
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| Digestive system |
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Diabetes
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Fat absorption
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Bile duct patency
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- Ceruletide
- Magnesium sulfate
- Sincalide
- Sorbitol
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Liver functional capacity
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- Galactose
- Sulfobromophthalein
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Gastric secretion
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- Betazole
- Caffeine and sodium benzoate
- Cation exchange resins
- Histamine phosphate
- Methylthioninium chloride
- Pentagastrin
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Exocrine pancreatic function
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- Bentiromide
- Pancreozymin
- Secretin
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| Endocrine system |
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Pituitary function
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- cortisol
- GH
- Pralmorelin
- Sermorelin
- Somatorelin
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Thyroid function
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Fertility disturbances
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| Tuberculosis |
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| Renal function |
- Alsactide
- Aminohippuric acid
- Indigo carmine
- Inulin and other polyfructosans
- Phenolsulfonphthalein
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English Journal
- Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.
- Cendrowski J1, Lobo VJ1, Sendler M2, Salas A3, Kühn JP4, Molero X5, Fukunaga R6, Mayerle J2, Lerch MM2, Real FX7.
- Gut.Gut.2015 Jun;64(6):937-47. doi: 10.1136/gutjnl-2013-306068. Epub 2014 Jul 18.
- OBJECTIVE: Pancreatic acinar cell maturation is dependent on the activity of the pancreas transcription factor 1 (PTF1) complex. Induction of pancreatitis leads to MAP kinase activation and transient suppression of the acinar differentiation programme. We investigated the role of MAP kinase-interact
- PMID 25037190
- Histone deacetylase regulates trypsin activation, inflammation, and tissue damage in acute pancreatitis in mice.
- Hartman H1, Wetterholm E, Thorlacius H, Regnér S.
- Digestive diseases and sciences.Dig Dis Sci.2015 May;60(5):1284-9. doi: 10.1007/s10620-014-3474-y. Epub 2014 Dec 10.
- BACKGROUND: The onset of acute pancreatitis (AP) is characterized by early protease activation followed by inflammation and organ damage, but the mechanisms are poorly understood.AIMS: We hypothesized that histone deacetylase (HDAC) inhibition might exert protective effects on AP and investigated th
- PMID 25492506
- NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.
- Chen NM1, Singh G2, Koenig A3, Liou GY4, Storz P4, Zhang JS5, Regul L2, Nagarajan S6, Kühnemuth B2, Johnsen SA6, Hebrok M7, Siveke J8, Billadeau DD9, Ellenrieder V1, Hessmann E10.
- Gastroenterology.Gastroenterology.2015 May;148(5):1024-1034.e9. doi: 10.1053/j.gastro.2015.01.033. Epub 2015 Jan 23.
- BACKGROUND & AIMS: Oncogenic mutations in KRAS contribute to the development of pancreatic ductal adenocarcinoma, but are not sufficient to initiate carcinogenesis. Secondary events, such as inflammation-induced signaling via the epidermal growth factor receptor (EGFR) and expression of the SOX
- PMID 25623042
Japanese Journal
- 家兎におけるIDPN誘発血漿モノアミン代謝物上昇への Ceruletide 拮抗 : Ceruletide の不随意運動抑制作用の機序に関する研究
- 内野 啓子
- 東邦醫學會雜誌 = Journal of the Medical Society of Toho University 43(6), 590-597, 1997-03-01
- NAID 10012230224
- 神経ペプチドのマウス唾液分泌反応の調節に及ぼす影響の研究 : cholecystokinin-octapeptide およびその近縁物質 ceruletide の自律神経作動薬による唾液分泌反応に関する薬理学的解析
- 大久保 昇
- 岩手医科大学歯学雑誌 = Dental journal of Iwate Medical University 21(3), 223-231, 1996-12-25
- NAID 10031152331
- サルの L-Dopa-induced dyskinesia に対する Ceruletide の長期効果
- 溝渕 雅之
- 岡山医学会雑誌 104(11-12), 1173-1187, 1992-12
- … The long-lasting effects of ceruletide(CLT), a cholecystokinin-8(CCK-8) analogue, on involuntary movements were investigated. …
- NAID 120002308657
Related Links
- Identification Name Ceruletide Accession Number DB00403 (APRD00861) Type Small Molecule Groups Approved Description Caerulein is a specific decapeptide similar in action and composition to the natural gastrointestinal peptide ...
- ceruletide a compound isolated from the skin of an Australian frog, with activity similar to gastrin and pancreozymin. It causes contraction of the gallbladder and relaxation of the sphincter of Oddi. Used in humans to treat paralytic ...
Related Pictures
★リンクテーブル★
[★]
- 英
- ceruletide、ceruletide diethylamine
- 関
- セルレイン、セルレチドジエチルアミン
[★]
セルレイン
- 関
- caerulein、ceruletide
[★]
- 関
- ceruletide