Hyperoxic resuscitation improves survival but worsens neurologic outcome in a rat polytrauma model of traumatic brain injury plus hemorrhagic shock.
Proctor JL1, Scutella D, Pan Y, Vaughan J, Rosenthal RE, Puche A, Fiskum G.
The journal of trauma and acute care surgery.J Trauma Acute Care Surg.2015 Oct;79(4 Suppl 2 Proceedings of 2014 Military Health System Research Symposium):S101-S109.
BACKGROUND: Many traumatic brain injury (TBI) patients experience additional injuries, including those that result in hemorrhagic shock (HS). Interactions between HS and TBI can include reduced brain O2 delivery, resulting in partial cerebral ischemia and worse neurologic outcome. This study tested
Neuropharmacology.Neuropharmacology.2015 Oct;97:133-41. doi: 10.1016/j.neuropharm.2015.05.037. Epub 2015 Jun 10.
Anticancer therapy based on the repeated administration of oxaliplatin is limited by the development of a neuropathic syndrome difficult to treat. Oxaliplatin neurotoxicity is based on complex nervous mechanisms, the comprehension of the role of single neurotransmitters and the knowledge of the sign
Intermediate Progenitors Facilitate Intracortical Progression of Thalamocortical Axons and Interneurons through CXCL12 Chemokine Signaling.
Abe P1, Molnár Z2, Tzeng YS3, Lai DM4, Arnold SJ5, Stumm R6.
The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2015 Sep 23;35(38):13053-63. doi: 10.1523/JNEUROSCI.1488-15.2015.
Glutamatergic principal neurons, GABAergic interneurons and thalamocortical axons (TCAs) are essential elements of the cerebrocortical network. Principal neurons originate locally from radial glia and intermediate progenitors (IPCs), whereas interneurons and TCAs are of extrinsic origin. Little is k
cerebrocortical pertaining to the cerebral cortex. cerebrocortical malacia see polioencephalomalacia. cerebrocortical necrosis see polioencephalomalacia. ... And the kinds of brain injuries are different today "The kinds of deficits we're ...
polioencephalomalacia (pō'lē-ō-en-sef'ă-lō-mă-lā'shē-ă), Cerebrocortical necrosis in sheep and goats, also seen in cattle, deer, and antelope. Associated with thiamine deficiency, water deprivation-sodium ion toxicosis, lead poisoning ...