関: central nervous system angiitis、central nervous system vasculitis、cerebral vasculitis、CNS vasculitis、granulomatous angiitis、granulomatous arteritis

WordNet

of or relating to the cerebrum or brain; "cerebral hemisphere"; "cerebral activity"
involving intelligence rather than emotions or instinct; "a cerebral approach to the problem"; "cerebral drama" (同)intellectual
inflammation of a blood vessel or lymph duct

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大脳の,脳の / 頭脳的な,知的な

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/18 12:41:23」(JST)

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Cerebral vasculitis or central nervous system vasculitis (sometimes the word angiitis is used instead of "vasculitis") is vasculitis (inflammation of the blood vessel wall) involving the brain and occasionally the spinal cord. It may produce a wide range of neurological symptoms, such as headache, difficulty moving or coordinating part of the body, changes in sensation, and alterations in perception, thought or behaviour, as well as the phenomena of a mass lesion in the brain leading to coma and herniation. Some of its symptoms may resemble multiple sclerosis.^[1] 10% have associated cerebral hemorrhage.^[2]

Causes

"Primary" CNS vasculitis is said to be present if there is no underlying cause. More commonly, the disease occurs in the setting of other medical conditions: infections, other forms of systemic vasculitis such as Wegener's granulomatosis or polyarteritis nodosa, connective tissue diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, particular medications and drugs (amphetamine, cocaine and heroin), certain forms of cancer (particularly lymphomas, leukemia and lung cancer) and Behçet's disease. It may imitate, and is in turn imitated by, a number of other diseases that affect the blood vessels of the brain diffusely such as fibromuscular dysplasia and thrombotic thrombocytopenic purpura.^[2]

Diagnosis and treatment

Cerebral angiography and magnetic resonance imaging, and ultimately biopsy of the brain, are often required for its diagnosis. Once confirmed, various tests are often performed to establish whether the vasculitis is primary or the result of an underlying cause. Treatment is with glucocorticoids, often with additional immunosuppression with medication such as cyclophosphamide to decrease the immune system's attack on the body's own tissues.^[2] Cerebral vasculitis is a very rare condition that is difficult to diagnose, and as a result there are significant variations in the way it is diagnosed and treated.^[3]

References

^ Scolding NJ, Jayne DR, Zajicek JP, Meyer PA, Wraight EP, Lockwood CM (January 1997). "Cerebral vasculitis--recognition, diagnosis and management". QJM 90 (1): 61–73. doi:10.1093/qjmed/90.1.61. PMID 9093590.
^ ^a ^b ^c Rehman HU (November 2000). "Primary angiitis of the central nervous system" (PDF). J R Soc Med 93 (11): 586–8. PMC 1298150. PMID 11198690.
^ Scolding NJ, Wilson H, Hohlfeld R, Polman C, Leite I, Gilhus N (July 2002). "The recognition, diagnosis and management of cerebral vasculitis: a European survey". Eur. J. Neurol. 9 (4): 343–7. doi:10.1046/j.1468-1331.2002.00422.x. PMID 12099915.

External links

Central Nervous System Vasculitis at the Johns Hopkins Hospital vasculitis centre
Primary angiitis of the central nervous system from the Cleveland Clinic

UpToDate Contents

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1. 成人における中枢神経系の原発性血管炎 primary angiitis of the central nervous system in adults
2. Overview of and approach to the vasculitides in adults
3. 小児血管炎：マネージメントの概要 vasculitis in children management overview
4. 脳アミロイドアンギオパチー cerebral amyloid angiopathy
5. 皮膚小血管性血管炎の概要 overview of cutaneous small vessel vasculitis

English Journal

Cerebrospinal fluid Coccidioides antigen testing in the diagnosis and management of central nervous system coccidioidomycosis.

Bamberger DM1, Pepito BS1, Proia LA2, Ostrosky-Zeichner L3, Ashraf M3, Marty F4, Scully E4, Wheat LJ5.
Mycoses.Mycoses.2015 Oct;58(10):598-602. doi: 10.1111/myc.12366. Epub 2015 Sep 3.
The goal of this study was to report on the potential utility of cerebrospinal fluid (CSF) Coccidioides antigen testing in the diagnosis and management of Coccidioides meningitis. We retrospectively reviewed medical records of seven patients with Coccidioides meningitis who had Coccidioides antigen
PMID 26393436

[Cerebral amyloid angiopathy and dementia].

Berlit P1, Keyvani K2, Krämer M3, Weber R3.
Der Nervenarzt.Nervenarzt.2015 Sep 19. [Epub ahead of print]
Cerebral amyloid angiopathy (CAA) is one of the most frequent causes of intracerebral hemorrhage (ICH). The deposition of beta amyloid leads to vascular fragility due to degeneration of vessel walls, formation of microaneurysms particularly in cortical blood vessels and fibrinoid vessel wall necrosi
PMID 26384105

Spontaneous reports of vasculitis as an adverse event following immunization: A descriptive analysis across three international databases.

Felicetti P1, Trotta F2, Bonetto C2, Santuccio C2, Pernus YB3, Burgner D4, Chandler R5, Girolomoni G6, Hadden RD7, Kochar S8, Kukucu M9, Monaco G10, Ozen S11, Pahud B12, Phuong L13, Bachtiar NS14, Teeba A15, Top K16, Varricchio F17, Wise RP18, Zanoni G19, Živkovic S20, Bonhoeffer J21; Brighton Collaboration Vasculitis Working Group.
Vaccine.Vaccine.2015 Sep 18. pii: S0264-410X(15)01293-1. doi: 10.1016/j.vaccine.2015.09.027. [Epub ahead of print]
BACKGROUND: Vasculitides have been reported as adverse events following immunization (AEFI) following various vaccines. We describe reports of vasculitis to three international spontaneous reporting systems.METHODS: All spontaneous reports of vasculitis following immunization between January 2003 an
PMID 26392009

Japanese Journal

症例報告 6年間経過観察しえた脳アミロイド血管症の1例 : 可逆性の大脳白質病変の随伴について

細井泰志,内山剛,吉田眞理 [他]
臨床神経学 52(2), 90-95, 2012-02
NAID 40019200827

Cerebral Vasculitis Associated With Amyloid Angiopathy : Case Report

MORISHIGE Masaki,ABE Tatsuya,KAMIDA Tohru,HIKAWA Takamitsu,FUJIKI Minoru,KOBAYASHI Hidenori,OKAZAKI Toshiro,KIMURA Noriyuki,KUMAMOTO Toshihide,YAMADA Akira,KAWANO Yoshihisa
Neurologia medico-chirurgica = 神経外科 50(4), 336-338, 2010-04-15
… A 78-year-old female presented with coexisting primary angiitis of the central nervous system (CNS) and cerebral amyloid angiopathy (CAA) manifesting as motor aphasia caused by a left frontal lobe lesion. …
NAID 10026192413

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リンク元	「脳血管炎」「CNS vasculitis」「granulomatous angiitis」「granulomatous arteritis」「cerebral vasculitis」
関連記事	「cerebral」