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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/12/05 13:42:53」(JST)
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Cephems are a sub-group of β-lactam antibiotics including cephalosporins and cephamycins.[1]
References[edit]
- ^ "medscape.com". Retrieved 2008-12-29.
Antibacterials: cell envelope antibiotics (J01C-J01D)
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Intracellular |
- inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
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Glycopeptide |
- inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
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β-lactams/
(inhibit PBP
cross-links) |
Penicillins
(penams)
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Extended sp.
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- aminopenicillins: Amoxicillin#
- Ampicillin# (Pivampicillin
- Hetacillin
- Bacampicillin
- Metampicillin
- Talampicillin)
- Epicillin
- carboxypenicillins: Carbenicillin (Carindacillin)
- Ticarcillin
- Temocillin
- ureidopenicillins: Azlocillin
- Piperacillin
- Mezlocillin
- other: Mecillinam (Pivmecillinam)
- Sulbenicillin
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Narrow sp.
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β-lactamase sensitive
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- Benzylpenicillin (G)#: Clometocillin
- Benzathine benzylpenicillin#
- Procaine benzylpenicillin#
- Azidocillin
- Penamecillin
- Phenoxymethylpenicillin (V)#: Propicillin
- Benzathine phenoxymethylpenicillin
- Pheneticillin
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β-lactamase resistant
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- Cloxacillin# (Dicloxacillin
- Flucloxacillin)
- Oxacillin
- Meticillin
- Nafcillin
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Penems
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Carbapenems
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- Biapenem
- Ertapenem
- antipseudomonal (Doripenem
- Imipenem
- Meropenem)
- Panipenem
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Cephalosporins/Cephamycins
(cephems)
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1st (PEcK)
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- Cefazolin#
- Cefacetrile
- Cefadroxil
- Cefalexin
- Cefaloglycin
- Cefalonium
- Cefaloridine
- Cefalotin
- Cefapirin
- Cefatrizine
- Cefazedone
- Cefazaflur
- Cefradine
- Cefroxadine
- Ceftezole
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2nd (HEN)
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- Cefaclor
- Cefamandole
- Cefminox
- Cefonicid
- Ceforanide
- Cefotiam
- Cefprozil
- Cefbuperazone
- Cefuroxime
- Cefuzonam
- cephamycin (Cefoxitin
- Cefotetan
- Cefmetazole)
- carbacephem (Loracarbef)
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3rd
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- Cefixime#
- Ceftriaxone#
- antipseudomonal (Ceftazidime#
- Cefoperazone)
- Cefcapene
- Cefdaloxime
- Cefdinir
- Cefditoren
- Cefetamet
- Cefmenoxime
- Cefodizime
- Cefotaxime
- Cefpimizole
- Cefpiramide
- Cefpodoxime
- Cefsulodin
- Cefteram
- Ceftibuten
- Ceftiolene
- Ceftizoxime
- oxacephem (Flomoxef
- Latamoxef ‡)
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4th (antips-)
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- Cefepime
- Cefozopran
- Cefpirome
- Cefquinome
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5th
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- Ceftobiprole
- Ceftaroline fosamil
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Veterinary
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- Ceftiofur
- Cefquinome
- Cefovecin
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Monobactams
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- Aztreonam
- Tigemonam
- Carumonam
- Nocardicin A
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β-lactamase inh.
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- penam (Sulbactam
- Tazobactam)
- clavam (Clavulanic acid)
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Combinations
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- Amoxicillin/clavulanic acid#
- Imipenem/cilastatin#
- Ampicillin/flucloxacillin
- Ampicillin/sulbactam (Sultamicillin)
- Piperacillin/tazobactam
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Other |
- polymyxins/detergent (Colistin
- Polymyxin B)
- depolarizing (Daptomycin)
- hydrolyze NAM-NAG (Lysozyme)
- Gramicidin
- Isoniazid
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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gr+f/gr+a (t)/gr-p (c)/gr-o
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drug (J1p, w, n, m, vacc)
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English Journal
- Third-generation cephalosporin-resistant non-typhoidal Salmonella isolated from human feces in Japan.
- Saito S1, Koori Y, Ohsaki Y, Osaka S, Oana K, Nagano Y, Arakawa Y, Nagano N.
- Japanese journal of infectious diseases.Jpn J Infect Dis.2016 Aug 31. [Epub ahead of print]
- Detection and characterization of β-lactamase genes in a total of ten non-typhoidal Salmonella (NTS) clinical isolates exhibiting resistance to the third-generation cephalosporins collected during 2012 -2014 in Japan were conducted. Among five strains with cefotaxime MIC (minimum inhibitory concent
- PMID 27580578
- [Serious Coagulation Dysfunction in a Patient with Gallstone-related Cholecystitis Successfully Treated with Vitamin K].
- Shimamoto S, Tanaka A, Tsuchida K, Hayashi K, Sawa T.
- Masui. The Japanese journal of anesthesiology.Masui.2016 Apr;65(4):407-10.
- An 85-year-old woman with a diagnosis of choledocholithiasis due to common duct stones gradually developed severe coagulation dysfunction over the course of 27 days after hospitalization. Initial clinical findings were fever, general malaise, and obstructive jaundice. She was treated with fasting, a
- PMID 27188119
- Evaluation of antimicrobial prophylaxis against postoperative infection after spine surgery: Limit of the first generation cephem.
- Iida Y1, Inoue Y1, Hasegawa K1, Tsuge S1, Yokoyama Y1, Nakamura K1, Fukano R1, Takamatsu R1, Wada A1, Takahashi H2.
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.J Infect Chemother.2016 Mar;22(3):157-61. doi: 10.1016/j.jiac.2015.12.005. Epub 2016 Jan 21.
- In our department, first-generation cephem (CEZ) are generally administered for 2 days as antimicrobial prophylaxis (AMP) for spinal surgery. However, the incidence of surgical site infection (SSI) has recently increased, particularly cases involving coagulase-negative Staphylococci (CNS) as an etio
- PMID 26806151
Japanese Journal
- セフェム系薬剤 (特集 感染症診療のポイント) -- (救急・集中治療領域での抗菌治療)
- 小林 敦子
- 救急医学 = The Japanese journal of acute medicine 38(2), 182-185, 2014-02
- NAID 40019975396
- 絶食・抗生物質投与によるビタミンK欠乏に起因すると思われる凝固障害で硬膜外穿刺部より多量の出血を認めた1例
- 坂本 昇太郎,高雄 由美子,上嶋 江利 [他],柳本 富士雄,前川 信博
- The journal of the Japan Society of Pain Clinicians = 日本ペインクリニック学会誌 19(4), 519-522, 2012-10-25
- … Preoperative oral limitation, insufficient absorption caused by ileus and treatment with cephem antibiotics had led to this deficiency. … We should pay attention when we administer cephem antibiotics containing N-methyl-thiotetrazole to a patient with long time fasting. …
- NAID 10031127009
- 〈Originals〉Antimicrobials for the treatment of febrile neutropenia clinical usefulness of antimicrobial cycling
- Tatsumi Yoichi,Kanamaru Akihisa,Matsumura Itaru
- Acta Medica Kinki University 37(1), 9-18, 2012-06
- … For 448 patients admitted to our hospital, the use of carbapenem, penicillin, fluoroquinolone, and cephem antibiotics (all of which were injectable preparations) was rotated in this order at 3-month intervals over a two-year period (antimicrobial cycling). …
- NAID 120004226576
Related Links
- Search LookChem database of chemicals Around the World:cephem. ... cephem 97519-39-6 Oxa-cephem 75007-71-5 Dhoi-attac-cephem 150256-26-1 Propen-attac-cephem 141197-54-8 Methyl-attac-cephem 118680-12-9 5,6-Dhb ...
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オキサセフェム系抗生物質
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オキサセフェム系抗生物質