- 関
- centrosome amplification
WordNet
- the act of copying or making a duplicate (or duplicates) of something; "this kind of duplication is wasteful" (同)gemination
- small region of cytoplasm adjacent to the nucleus; contains the centrioles and serves to organize the microtubules (同)central_body
PrepTutorEJDIC
- 〈U〉複製(複写)すること / 〈C〉複製した物
UpToDate Contents
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English Journal
- Cullin 4A and 4B ubiquitin ligases interact with γ-tubulin and induce its polyubiquitination.
- Thirunavukarasou A1, Govindarajalu G, Singh P, Bandi V, Muthu K, Baluchamy S.
- Molecular and cellular biochemistry.Mol Cell Biochem.2015 Mar;401(1-2):219-28. doi: 10.1007/s11010-014-2309-7. Epub 2014 Dec 27.
- Regulated polyubiquitination is a key step for controlling protein degradation and maintaining proper balance between the proliferation of normal and uncontrolled cells. Addition of ubiquitin to the proteins by E3 ubiquitin ligases targets them for degradation by the 26S proteosome machinery. Discre
- PMID 25542213
- Centrin: another target of monastrol, an inhibitor of mitotic spindle.
- Duan L1, Wang TQ1, Bian W2, Liu W2, Sun Y3, Yang BS4.
- Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2015 Feb 25;137:1086-91. doi: 10.1016/j.saa.2014.08.050. Epub 2014 Sep 3.
- Monastrol, a cell-permeable inhibitor, considered to specifically inhibit kinesin Eg5, can cause mitotic arrest and monopolar spindle formation, thus exhibiting antitumor properties. Centrin, a ubiquitous protein associated with centrosome, plays a critical role in centrosome duplication. Moreover,
- PMID 25300040
- The Centrosome and Its Duplication Cycle.
- Fu J1, Hagan IM2, Glover DM1.
- Cold Spring Harbor perspectives in biology.Cold Spring Harb Perspect Biol.2015 Feb 2;7(2). pii: a015800. doi: 10.1101/cshperspect.a015800.
- The centrosome was discovered in the late 19th century when mitosis was first described. Long recognized as a key organelle of the spindle pole, its core component, the centriole, was realized more than 50 or so years later also to comprise the basal body of the cilium. Here, we chart the more recen
- PMID 25646378
Japanese Journal
- Emerging Connection Between Centrosome and DNA Repair Machinery
- Shimada Mikio,Komatsu Kenshi
- Journal of radiation research 50(4), 295-301, 2009-07-16
- … The centrosome consists of a pair of centrioles and the surrounding pericentriolar matrix (PCM). … After cytokinesis, daughter cells each acquire one centrosome, which subsequently duplicates at the G1/S phase in a manner that is dependent upon CDK2/cyclin-E activity. … Defects in the regulation of centrosome duplication lead to tumorigenesis through abnormal cell division and resulting inappropriate chromosome segregation. …
- NAID 10025912073
- The cancer prone PCS syndrome : relationship between chromosome dynamics aberration and centrosome amplification(Minireviews with the main theme: "Past, Current and Perspective Studies of the Genome, Chromosomes, and Chromatin")
- Izumi Hideki,Matsuura Shinya
- Chromosome science 11(1&2), 25-28, 2008
- … Another one is a centrosome because centrosomes define spindle poles and its abnormality leads to chromosome segregation errors and chromosome instability. … Here we show that the cells from PCS syndrome patients have dysregulated centrosome duplication machinery, resulting in centrosome amplification and multipolar mitosis. …
- NAID 110007339278
Related Links
- Centrosome duplication Distinct phases of the centrosome cycle have been identified. Disorientation, or disengagement, corresponds to the loss of the duplicative orthogonal tight association between mother and daughter centrioles.
- Review Centrosome replication, genomic instability and cancer A Krämer, K Neben and A D Ho Medizinische Klinik und Poliklinik V, Ruprecht-Karls-Universität, Heidelberg, Germany Correspondence to: A Krämer ...
Related Pictures
![a1 d1 centrosome duplication outside](https://1mg.info/0/4/x/2387.jpg)
![Centrosome (region pericentriolaire)](https://1mg.info/0/4/x/2388.jpg)
![Ch 1, 2, 3 Anatomy](https://1mg.info/0/4/x/2389.jpg)
![Centrioles Cell Division](https://1mg.info/0/4/x/2390.jpg)
![Back to article | Back to figures and](https://1mg.info/0/4/x/2391.jpg)
★リンクテーブル★
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- 英
- centrosome duplication、centrosome amplification
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- 関
- centrosome duplication