セフテゾール
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/11/19 18:36:14」(JST)
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Ceftezole
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Systematic (IUPAC) name |
(6R,7R)-8-oxo-7-{[2-(tetrazol-1-yl)acetyl]amino}-
3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-
1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
Clinical data |
Legal status |
?
|
Identifiers |
CAS number |
26973-24-0 |
ATC code |
J01DB12 |
PubChem |
CID 65755 |
ChemSpider |
59178 Y |
UNII |
2Z86SYP11W Y |
KEGG |
D07656 Y |
ChEMBL |
CHEMBL1697829 |
Chemical data |
Formula |
C13H12N8O4S3 |
Mol. mass |
440.484 g/mol |
SMILES
- O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)Cn3nnnc3)CSc4nncs4)C(=O)O
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InChI
-
InChI=1S/C13H12N8O4S3/c22-7(1-20-4-14-18-19-20)16-8-10(23)21-9(12(24)25)6(2-26-11(8)21)3-27-13-17-15-5-28-13/h4-5,8,11H,1-3H2,(H,16,22)(H,24,25)/t8-,11-/m1/s1 Y
Key:DZMVCVMFETWNIU-LDYMZIIASA-N Y
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Y (what is this?) (verify) |
Ceftezole (or ceftezol) is a cephalosporin antibiotic.
Antibacterials: cell envelope antibiotics (J01C-J01D)
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Intracellular |
- inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
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Glycopeptide |
- inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
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β-lactams/
(inhibit PBP
cross-links) |
Penicillins
(penams)
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Extended sp.
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- aminopenicillins: Amoxicillin#
- Ampicillin# (Pivampicillin
- Hetacillin
- Bacampicillin
- Metampicillin
- Talampicillin)
- Epicillin
- carboxypenicillins: Carbenicillin (Carindacillin)
- Ticarcillin
- Temocillin
- ureidopenicillins: Azlocillin
- Piperacillin
- Mezlocillin
- other: Mecillinam (Pivmecillinam)
- Sulbenicillin
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Narrow sp.
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β-lactamase sensitive
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- Benzylpenicillin (G)#: Clometocillin
- Benzathine benzylpenicillin#
- Procaine benzylpenicillin#
- Azidocillin
- Penamecillin
- Phenoxymethylpenicillin (V)#: Propicillin
- Benzathine phenoxymethylpenicillin
- Pheneticillin
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β-lactamase resistant
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- Cloxacillin# (Dicloxacillin
- Flucloxacillin)
- Oxacillin
- Meticillin
- Nafcillin
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Penems
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Carbapenems
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- Biapenem
- Ertapenem
- antipseudomonal (Doripenem
- Imipenem
- Meropenem)
- Panipenem
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Cephalosporins/Cephamycins
(cephems)
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1st (PEcK)
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- Cefazolin#
- Cefacetrile
- Cefadroxil
- Cefalexin
- Cefaloglycin
- Cefalonium
- Cefaloridine
- Cefalotin
- Cefapirin
- Cefatrizine
- Cefazedone
- Cefazaflur
- Cefradine
- Cefroxadine
- Ceftezole
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2nd (HEN)
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- Cefaclor
- Cefamandole
- Cefminox
- Cefonicid
- Ceforanide
- Cefotiam
- Cefprozil
- Cefbuperazone
- Cefuroxime
- Cefuzonam
- cephamycin (Cefoxitin
- Cefotetan
- Cefmetazole)
- carbacephem (Loracarbef)
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3rd
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- Cefixime#
- Ceftriaxone#
- antipseudomonal (Ceftazidime#
- Cefoperazone)
- Cefcapene
- Cefdaloxime
- Cefdinir
- Cefditoren
- Cefetamet
- Cefmenoxime
- Cefodizime
- Cefotaxime
- Cefpimizole
- Cefpiramide
- Cefpodoxime
- Cefsulodin
- Cefteram
- Ceftibuten
- Ceftiolene
- Ceftizoxime
- oxacephem (Flomoxef
- Latamoxef ‡)
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4th (antipseudomonal)
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- Cefepime
- Cefozopran
- Cefpirome
- Cefquinome
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5th
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- Ceftobiprole
- Ceftaroline fosamil
- Ceftolozane
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Veterinary
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- Ceftiofur
- Cefquinome
- Cefovecin
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Monobactams
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- Aztreonam
- Tigemonam
- Carumonam
- Nocardicin A
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β-lactamase inh.
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- penam (Sulbactam
- Tazobactam)
- clavam (Clavulanic acid)
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Combinations
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- Amoxicillin/clavulanic acid#
- Imipenem/cilastatin#
- Ampicillin/flucloxacillin
- Ampicillin/sulbactam (Sultamicillin)
- Piperacillin/tazobactam
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Other |
- polymyxins/detergent (Colistin
- Polymyxin B)
- depolarizing (Daptomycin)
- hydrolyze NAM-NAG (lysozyme)
- Gramicidin
- Isoniazid
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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gr+f/gr+a (t)/gr-p (c)/gr-o
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drug (J1p, w, n, m, vacc)
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English Journal
- A gold immunochromatographic assay for the rapid and simultaneous detection of fifteen β-lactams.
- Chen Y1, Wang Y, Liu L, Wu X, Xu L, Kuang H, Li A, Xu C.
- Nanoscale.Nanoscale.2015 Oct 2;7(39):16381-8. doi: 10.1039/c5nr04987c.
- A novel gold immunochromatographic assay (GICA) based on anti-β-lactam receptors was innovatively developed that successfully allowed rapid and simultaneous detection of fifteen β-lactams in milk samples in 5-10 minutes. By replacing the antibodies used in traditional GICA with anti-β-lactam rece
- PMID 26394361
- Feasibility and extension of universal quantitative models for moisture content determination in beta-lactam powder injections by near-infrared spectroscopy.
- Zhang XB1, Feng YC, Hu CQ.
- Analytica chimica acta.Anal Chim Acta.2008 Dec 23;630(2):131-40. doi: 10.1016/j.aca.2008.09.050. Epub 2008 Oct 1.
- In present work, we investigated the feasibility of universal calibration models for moisture content determination of a much complicated products system of powder injections to simulate the process of building universal models for drug preparations with same INN (International Nonproprietary Name)
- PMID 19012824
- Exploring Mn-doped ZnS quantum dots for the room-temperature phosphorescence detection of enoxacin in biological fluids.
- He Y1, Wang HF, Yan XP.
- Analytical chemistry.Anal Chem.2008 May 15;80(10):3832-7. doi: 10.1021/ac800100y. Epub 2008 Apr 12.
- While most research works focus on the development of quantum dots (QDs)-based fluorescence sensors, much less attention is paid to the phosphorescence properties of QDs and their potential for phosphorescence detection. In this work, the phosphorescence property of Mn-doped ZnS QDs is explored to d
- PMID 18407673
Japanese Journal
- 金城 俊夫,武藤 照美,木原 正子,源 宜之
- 岐阜大学農学部研究報告 51, 219-225, 1987-01-10
- エルシニアはY. pseudotuberculosisを除きβ-ラクタマーゼを産生する。このβ-ラクタマーゼ産生能に,エルシニアの菌種,生物型あるいは血清型によって,これらの分類の一助となりうるような差があるか否かを検討するため,各菌種のβ-ラクタム系抗生物質に対する感受性試験を行った。ヒト及び各種動物由来のY. enterocolitica B:1 81株,B:2 10株,B:3 30株,B:4 …
- NAID 110000976529
- Comparison of antibacterial activities of ceftriaxone and other cephems.
- 岩沢 武彦
- 耳鼻咽喉科臨床 79(10), 1986
- … It's activity was similar to that of Cefotaxime, Cefotiam, Cefoperazone, Ceftizoxime, Cefotetan, Latamoxef, Cefmenoxime and superior to that of Cefazolin, Cephapirin, Ceftezole and Cephacetrile against various pathogenic gram-negative bacteria.CTRX showed MICs of 3.13 to 12.5 μg/ml, its peak being 12.5 μg/ml against 60 strains of pathogenic P. …
- NAID 130001810015
- EPILEPTOGENIC ACTIVITY INDUCED BY INTRAVENOUS INJECTION OF CERTAIN CEPHALOSPORINS IN RATS
- HAIYU QUING,KITAZUMI KAZUHIRO,KAMEI CHIAKI,TASAKA KENJI
- Journal of pharmacobio-dynamics 7(8), 586-592, 1984-08
- … Ceftezole provided the most potent epileptogenic activity among the drugs tested. … Changes in seizure patterns on electroencephalogram (EEG) tracings and behavioral signs after administrations of cefotiam and cefazolin were similar to those seen after ceftezole, though the intensity and duration were less than those of ceftezole. …
- NAID 110003637794
Related Links
- ChemicalBook あなたのためにCeftezole(26973-24-0)の化学的性質を提供して、融点、価格、蒸気圧、沸点、毒性、比重、沸点、密度、分子式、分子量、物理的な性質、毒性 税関のコードなどの情報、同時にあなたは更にCeftezole ...
- Ceftezole (or ceftezol) is a cephalosporin antibiotic. v • d • e Antibacterials: cell wall disruption (J01C-J01D) Internal to membrane/ (inhibit peptidoglycan subunit synthesis and transport) NAM synthesis inhibition Fosfomycin , / ) · ...
Related Pictures
★リンクテーブル★
[★]
- 英
- ceftezole CTZ
- ラ
- ceftezolum
- 化
- セフテゾールナトリウム ceftezole sodium
- 関
- 抗菌薬、セファロスポリン系抗生物質
[★]
[★]
- 関
- ceftezole