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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/01 07:01:54」(JST)

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Cefpirome is a fourth-generation cephalosporin. Trade names include Cefrom, Keiten, Broact, Cefir. Cefpirome is considered highly active against Gram-negative bacteria, including Pseudomonas aeruginosa, and Gram-positive bacteria. It is marketed under the brand name of CEFROM by sanofi aventis group india .

Spectrum of Bacterial Susceptibility and Resistance[edit source | edit]

Currently, Bacteroides fragilis, Enterococci, Pseudomonas spp. and Staphylococci are resistant to Cefpirome Sulfate, and some Haemophilus spp. and Pneumococci have developed resistance to Cefpirome Sulfate to varying degrees. ^[1]

References[edit source | edit]

^ "Cefpirome Sulfate spectrum of bacterial susceptibility and Resistance". Retrieved 15 May 2012.

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UpToDate Contents

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1. グラム陰性桿菌性髄膜炎の診断および治療 diagnosis and treatment of gram negative bacillary meningitis
2. ビブリオ・バルニフィカス感染症 vibrio vulnificus infections
3. 鼻疽の治療および予後 treatment and prognosis of melioidosis

English Journal

Investigation on the interaction of cefpirome sulfate with lysozyme by fluorescence quenching spectroscopy and synchronous fluorescence spectroscopy.

Han R1, Liu B1, Li G1, Zhang Q1.
Luminescence : the journal of biological and chemical luminescence.Luminescence.2016 Mar;31(2):580-6. doi: 10.1002/bio.2998. Epub 2015 Aug 24.
The reaction mechanism of cefpirome sulfate with lysozyme at different temperatures (298, 310 and 318 K) was investigated using fluorescence quenching and synchronous fluorescence spectroscopy under simulated physiological conditions. The results clearly demonstrated that cefpirome sulfate cau
PMID 26304690

Tigecycline salvage therapy for necrotizing fasciitis caused by Vibrio vulnificus: Case report in a child.

Lin YS1, Hung MH1, Chen CC2, Huang KF1, Ko WC3, Tang HJ4.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.J Microbiol Immunol Infect.2016 Feb;49(1):138-41. doi: 10.1016/j.jmii.2013.04.008. Epub 2013 Jun 14.
Necrotizing fasciitis caused by Vibrio vulnificus is rarely reported in children. We describe a 12-year-old immunocompetent boy with necrotizing fasciitis caused by V. vulnificus. He was cured by radical and serial debridement and salvage therapy with intravenous cefpirome plus tigecycline. The in
PMID 23751766

The radiolytic studies of cefpirome sulfate in the solid state.

Zalewski P1, Skibiński R2, Szymanowska-Powałowska D3, Piotrowska H4, Kozak M5, Pietralik Z5, Bednarski W6, Cielecka-Piontek J7.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2016 Jan 25;118:410-6. doi: 10.1016/j.jpba.2015.11.008. Epub 2015 Nov 10.
The possibility of applying radiation sterilization to cefpirome sulfate was investigated. The lack of changes in the chemical structure of cefpirome sulfate irradiated with a dose of 25kGy, required to attain sterility, was confirmed by UV, FT-IR, Raman, DSC and chromatographic methods. Some radica
PMID 26597316

Japanese Journal

アンチバイオグラムとグラム染色を用いた抗菌薬投与設計支援が抗菌薬使用量と緑膿菌の抗菌薬感受性に及ぼす影響

日本環境感染学会誌 27(2), 105-112, 2012
NAID 130002129024

感染性内頸静脈血栓症の1症例

口腔・咽頭科 = Stomato-pharyngology 23(1), 111-115, 2010-03-31
NAID 10029058865

小児の化学療法および造血幹細胞移植での好中球減少期間におけるミカファンギンとホスフルコナゾールによる侵襲性真菌感染症予防の無作為割り付け試験成績

臨床血液 50(12), 1692-1699, 2009
NAID 130004501314

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★リンクテーブル★

リンク元	「セフピロム」
拡張検索	「cefpirome sulfate」

「セフピロム」

Cefpirome
Systematic (IUPAC) name
	1-{[(6R,7R)-7-[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-5H,6H,7H-cyclopenta[b]pyridin-1-ium
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	84957-29-9
ATC code	J01DE02
PubChem	CID 6917674
ChemSpider	23089536
UNII	S72Q2F09HY
KEGG	D07649
Chemical data
Formula	C22H22N6O5S2
Mol. mass	514.58 g/mol
	InChI InChI=1S/C22H22N6O5S2/c1-33-26-15(13-10-35-22(23)24-13)18(29)25-16-19(30)28-17(21(31)32)12(9-34-20(16)28)8-27-7-3-5-11-4-2-6-14(11)27/h3,5,7,10,16,20H,2,4,6,8-9H2,1H3,(H3-,23,24,25,29,31,32)/b26-15-/t16-,20+/m1/s1; Key:DKOQGJHPHLTOJR-XECLGWKCSA-N ;
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