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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/05 20:05:17」(JST)

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Cefditoren is a third-generation cephalosporin antibiotic for oral use. It is commonly marketed under the trade name Spectracef by Vansen Pharma Inc.

Cefditoren is also marketed under the name Meiact.^[1]

Spectrum of bacterial susceptibility

Cefditoren has a broad spectrum of activity and has been used to treat bacterial infections of the skin and respiratory tract including bronchitis, pneumonia, and tonsillitis. The following represents MIC susceptibility data for a few medically significant microorganisms.

Haemophilus influenzae: ≥0.063 μg/ml - 0.25 μg/ml
Staphylcoccus aureus: 0.25 μg/ml - >128 μg/ml (includes MRSA)
Streptococcus pyogenes: ≤0.004 μg/ml - 2 μg/ml

^[2]

Clinical use

Main article: Cephalosporin

Indications

Cefditoren is used to treat uncomplicated skin and skin structure infections, community-acquired pneumonia, acute bacterial exacerbation of chronic bronchitis (ABECB), pharyngitis, and tonsillitis.

Formulations

Cefditoren is available as 200 and 400 mg tablets. It can be formulated as the prodrug cefditoren pivoxil.

Chemical structure of cefditoren pivoxil

References

^ Meiact Full Description
^ http://www.toku-e.com/Assets/MIC/Cefditoren%20sodium.pdf

External links

Manufacturer's Product website
Manufacturer's prescribing information for Spectracef

UpToDate Contents

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1. セフェム系 cephalosporins
2. 患者情報：ペニシリンおよび関連抗菌薬に対するアレルギー（詳細） allergy to penicillin and related antibiotics beyond the basics

English Journal

Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals.

Fujimoto K, Takemoto K, Hatano K, Nakai T, Terashita S, Matsumoto M, Eriguchi Y, Eguchi K, Shimizudani T, Sato K, Kanazawa K, Sunagawa M, Ueda Y.SourceDrug Research Division, Dainippon Sumitomo Pharma Co, Ltd, Osaka, Japan.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Feb;57(2):697-707. doi: 10.1128/AAC.01051-12. Epub 2012 Nov 12.
SM-295291 and SM-369926 are new parenteral 2-aryl carbapenems with strong activity against major causative pathogens of community-acquired infections such as methicillin-susceptible Staphylococcus aureus, Streptococcus pneumoniae (including penicillin-resistant strains), Streptococcus pyogenes, Ente
PMID 23147735

A case of fitz-hugh-curtis syndrome complicated by appendicitis conservatively treated with antibiotics.

Kazama I, Nakajima T.SourceDepartment of Physiology I, Tohoku University Graduate School of Medicine, Seiryo-cho, Aoba-ku, Sendai, Miyagi, Japan.
Clinical medicine insights. Case reports.Clin Med Insights Case Rep.2013;6:35-40. doi: 10.4137/CCRep.S11522. Epub 2013 Mar 4.
A 27-year-old woman developed a low grade fever and increased vaginal discharge that persisted for 2 weeks. Intermittent abdominal pain in the right upper quadrant had been experienced over the previous few days. Due to her clinical manifestations and typical abdominal computed tomography (CT) findi
PMID 23515004

Japanese Journal

Cefditoren pivoxil 細粒高用量の小児における細菌性肺炎, 急性中耳炎, 急性鼻副鼻腔炎を対象とした臨床試験

砂川慶介,尾内一信,鈴木賢二,堀誠治
日本化学療法学会雜誌 = Japanese journal of chemotherapy 60(4), 478-491, 2012-07-10
NAID 10030787998

薬物急性副鼻腔炎の成人例に対するCDTR-PIの高用量投与治療(200mg/回×3回/日)の有用性の検討

萩野幸治,石原明子,角卓郎,畑中章生,和佐野有紀,戸叶尚史,喜多村健
耳鼻咽喉科臨床 105(10), 999-1009, 2012
… In contrast, Cefditoren Pivoxil (CDTR-PI) still preserves high antibacterial activity against both PRSP and BLNAR which are common drug-resistant bacteria, and high-dose medication with this drug is recommended at the time of acute sinusitis or acute aggravation of chronic sinusitis. …
NAID 130002141429

小児急性A群β溶血性レンサ球菌性咽頭・扁桃炎に対する抗菌薬療法 : cefditoren pivoxil 5 日間投与と amoxicillin 10 日間投与の臨床効果, 細菌学的効果, 口腔内常在菌叢への影響の比較検討

津村直幹,長井健祐,日高秀信,大津寧,田中悠平,池澤滋,本間真一,進藤静生,生方公子
The Japanese journal of antibiotics 64(3), 179-190, 2011-06-25
NAID 10029695556

Related Pictures

★リンクテーブル★

リンク元

「セフジトレン」

Cefditoren
Systematic (IUPAC) name
	(7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((Z)-2-(4-methylthiazol-5-yl)vinyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade names	Spectracef
AHFS/Drugs.com	monograph
MedlinePlus	a605003
Legal status	?
Identifiers
CAS number	104145-95-1
ATC code	J01DD16
PubChem	CID 9870843
DrugBank	DB01066
ChemSpider	8046534
UNII	81QS09V3YW
KEGG	D07639
ChEBI	CHEBI:59343
Chemical data
Formula	C19H18N6O5S3
Mol. mass	506.58 g/mol
	SMILES O=C3N2/C(=C(/C=C\c1scnc1C)CS[C@@H]2[C@@H]3NC(=O)C(=N\OC)/c4nc(sc4)N)C(=O)O;
	InChI InChI=1S/C19H18N6O5S3/c1-8-11(33-7-21-8)4-3-9-5-31-17-13(16(27)25(17)14(9)18(28)29)23-15(26)12(24-30-2)10-6-32-19(20)22-10/h3-4,6-7,13,17H,5H2,1-2H3,(H2,20,22)(H,23,26)(H,28,29)/b4-3-,24-12-/t13-,17-/m1/s1 ; Key:KMIPKYQIOVAHOP-YLGJWRNMSA-N ;
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　　[★]

英: cefditoren CDTR
化: セフジトレンピボキシル cefditoren pivoxil CDTR-PI
商: メイアクト
関: 抗菌薬

第三世代セフェム系抗生物質
経口用セフェム系抗生物質製剤

効能又は効果

メイアクトMS錠100mg

適応菌種

セフジトレンに感性のブドウ球菌属、レンサ球菌属、肺炎球菌、モラクセラ（ブランハメラ）・カタラーリス、大腸菌、シトロバクター属、クレブシエラ属、エンテロバクター属、セラチア属、プロテウス属、モルガネラ・モルガニー、プロビデンシア属、インフルエンザ菌、ペプトストレプトコッカス属、バクテロイデス属、プレボテラ属、アクネ菌

適応症

表在性皮膚感染症、深在性皮膚感染症、リンパ管・リンパ節炎、慢性膿皮症、外傷・熱傷及び手術創等の二次感染、乳腺炎、肛門周囲膿瘍、咽頭・喉頭炎、扁桃炎（扁桃周囲炎、扁桃周囲膿瘍を含む）、急性気管支炎、肺炎、肺膿瘍、慢性呼吸器病変の二次感染、膀胱炎、腎盂腎炎、胆嚢炎、胆管炎、バルトリン腺炎、子宮内感染、子宮付属器炎、眼瞼膿瘍、涙嚢炎、麦粒腫、瞼板腺炎、中耳炎、副鼻腔炎、歯周組織炎、歯冠周囲炎、顎炎

薬効薬理