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of damaged or necrotic tissue; cheeselike

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チーズの[ような] / 《米俗》安っぽい,低級な

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/01 03:24:15」(JST)

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Caseous necrosis is a form of cell death in which the tissue maintains a cheese-like appearance.^[1] The dead tissue appears as a soft and white proteinaceous dead cell mass.

Causes

Frequently, caseous necrosis is encountered in the foci of tuberculous infections.^[2] It can also be caused by syphilis and certain fungi.

A similar appearance can be associated with histoplasmosis, cryptococcosis, and coccidioidomycosis.^[3]

Appearance

In caseous necrosis no histological architecture is preserved. On microscopic examination with H&E staining, it is characterized by acellular pink areas of necrosis surrounded by a granulomatous inflammatory process.

When the hilar lymph node for instance is infected with tuberculosis and leads to caseous necrosis, its gross appearance can be a cheesy tan to white, which is why this type of necrosis is often depicted as a combination of both coagulative and liquefactive necrosis.

However, in the lung, extensive caseous necrosis with confluent cheesy tan granulomas is typical. The tissue destruction is so extensive that there are areas of cavitation (also known as cystic spaces). See Ghon's complex.

Caseous necrosis in the lung
Caseous necrosis in the pleura
Caseous necrosis in the kidney

References

^ Robbins and Cotran: Pathologic Basis of Disease, 8th Ed. 2010. Pg. 16
^ Robbins and Cotran: Pathologic Basis of Disease, 8th Ed. 2010. Pg. 16
^ "Pulmonary Pathology". Retrieved 2008-11-21.

External links

Microscope images of caseous necrosis
Image of a hilar lymph node demonstrating caseous necrosis
Image of a caseating granuloma of tuberculosis in the adrenal gland

UpToDate Contents

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1. 僧帽弁輪石灰化 mitral annular calcification
2. 線維性縦隔炎 fibrosing mediastinitis
3. Clinical manifestations and complications of pulmonary tuberculosis
4. 小児における非結核性抗酸菌性リンパ節炎の概要 overview of nontuberculous mycobacterial lymphadenitis in children
5. 肺ヒストプラスマ症の病因および臨床的特徴 pathogenesis and clinical features of pulmonary histoplasmosis

English Journal

Inspection of lymph nodes for caseous lymphadenitis and its effect on the density of microbes on sheep carcasses.

Jordan D, Sentance CB, Spooncer WF, Balan JA, Morris SM.SourceNew South Wales Department of Primary Industries, 1243 Bruxner Highway, Wollongbar, NSW 2478, Australia.
Meat science.Meat Sci.2012 Dec;92(4):837-40. Epub 2012 Jul 22.
This study aimed to measure the amount of microbial contamination caused by inspecting the lymph nodes of adult sheep carcasses for caseous lymphadenitis (CLA). Surface swabs from carcasses pre-inspection (N=296) and post-inspection (N=296) were obtained for enumeration of indicator organisms at thr
PMID 22863079

[Nematodes of the genus Oesophagostomum: an emerging risk for humans and apes in Africa?].

Guillot J, Vermeulen B, Lafosse S, Chauffour S, Cibot M, Narat V, Masi S, Nieguitsila A, Snounou G, Bain O, Krief S.SourceUMR Bipar, Service de Parasitologie, Ecole Nationale Vétérinaire d'Alfort, 7 avenue du Général de Gaulle, 94704 Maisons-Alfort Cedex. jguillot@vet-alfort.fr
Bulletin de l'Académie nationale de médecine.Bull Acad Natl Med.2012 Nov;195(8):1955-63; discussion 1963.
Nematodes of the genus Oesophagostomum are common intestinal parasites found in cattle, pigs and primates. They can cause severe illness, resulting from the formation of granulomas, caseous lesions and abscesses in the intestinal wall. Human oesophagostomosis is endemic in northern Ghana and Togo. I
PMID 22844754

Japanese Journal

肺非結核性抗酸菌症合併肺癌にmucosa-associated lymphoid tissue(MALT)リンパ腫を併発した1例

大月鷹彦,西野亮平,秋田慎,中尾涼子,山野上直樹,宮崎こずえ,山岡直樹,倉岡敏彦,大成亮次,木村厚雄,奥道恒夫
気管支学 : 日本気管支研究会雑誌 34(2), 113-119, 2012-03-25
背景.肺原発MALTリンパ腫は比較的稀であり,その成因は不明のことが多い.症例.63歳女性.肺非結核性抗酸菌症の治療歴あり.胸部X線における異常陰影の精査のため当院を受診.胸部CTで右上葉に不整形陰影,右中葉に模状陰影および左肺門部に境界明瞭な結節陰影を認めた.右上葉の不整形陰影に対する気管支鏡下生検で肺腺癌と診断し,また気管支洗浄液よりMycobacterium aviumの存在を認めた.flu …
NAID 110009437390

Pulmonary Sequestration with Tuberculosis Confined to the Sequestrated Lung

HUANG Xiaoying,XU Xiaomei,YU Chang,FAN Rong,LU Yuanyuan,LU Sansan,WANG Liangxing
Annals of thoracic and cardiovascular surgery 18(1), 51-55, 2012-02-01
… Microscopy demonstrated resected sequestrated lung tissue that was mainly composed of caseous necrosis with Langhans cells. …
NAID 10030235811

Solitary pulmonary mass due to nontuberculous mycobacterial disease showing abnormal 18F-fluorodeoxyglucose accumulation and an elevated serum CA19-9 level

林哲也,森田琢也,花岡伸治,立花秀一,勝間田敬弘
日本呼吸器外科学会雑誌 26(1), 075-078, 2012
… Pathological findings of the resected specimen were aggregated epithelioid granulomas with multinucleated giant cells including partial caseous necrosis. … There were acid-fast-positive bacilli around the caseous necrosis. …
NAID 130002114782