関: carpipramine hydrochloride、carpipramine maleate

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/12 10:28:05」(JST)

wiki en

Carpipramine (Prazinil, Defekton) is an atypical antipsychotic used for the treatment of schizophrenia and anxiety in France and Japan.^[1]^[2]^[3]^[4] In addition to its neuroleptic and anxiolytic effects, carpipramine also has hypnotic properties.^[3] It is structurally related to both tricyclics like imipramine and butyrophenones like haloperidol.^[3]

References

^ Deniker P, Lôo H, Zarifian E, Verdeaux G, Garreau G (1977). "[A new psychotropic drug: carpipramine, intermediate compound between 2 therapeutic classes]". Encephale (in French) 3 (2): 133–48. PMID 19231.
^ Pislová J, Pisl I, Petránová T, Petrová M (August 1974). "Clinical experience with carpipramine (Defekton)". Act Nerv Super (Praha) 16 (3): 168–9. PMID 4608287.
^ ^a ^b ^c José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. ISBN 3-527-31058-4.
^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.

English Journal

Iminodibenzyl class antipsychotics for schizophrenia: a systematic review and meta-analysis of carpipramine, clocapramine, and mosapramine.

Kishi T1, Matsunaga S1, Matsuda Y1, Iwata N1.
Neuropsychiatric disease and treatment.Neuropsychiatr Dis Treat.2014 Dec 10;10:2339-51. doi: 10.2147/NDT.S73464. eCollection 2014.
BACKGROUND: We conducted a meta-analysis of the iminodibenzyl antipsychotics carpipramine, clocapramine, and mosapramine, which are classified as second-generation antipsychotics (SGAs) for schizophrenia treatment.METHODS: We searched data that had been published in PubMed, the Cochrane Library data
PMID 25525363

[Hebephrenic schizophrenia].

Frikha A1, Goldberger C.
L'Encephale.Encephale.2005 Oct;31 Pt 2:S27-9.
PMID 16673701

Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain.

Oka T1, Hamamura T, Lee Y, Miyata S, Habara T, Endo S, Taoka H, Kuroda S.
Life sciences.Life Sci.2004 Nov 26;76(2):225-37.
Acute administration of typical and atypical antipsychotics has been reported to induce regionally distinct patterns of c-Fos expression in the rat forebrain. Furthermore, atypical index, the difference in the extent of increased Fos-like immunoreactivity (Fos-LI) in the nucleus accumbens (NAc) shel
PMID 15519367

Japanese Journal

Crystal Structure of Antipsychotic Agent, 1'-[3-(10, 11-dihydro-5H-dibenz[b, f]-azepin-5-yl)propyl][1, 4'-bipiperidine]-4'-carboxamide(Carpipramine)

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 15(5), 505-506, 1999-05
NAID 10002419901

Crystal Structure of Antipsychotic Agent, 1'-(3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl) (1,4'-bipiperidine)-4'-carboxamide (Carpipramine).

Analytical Sciences 15(5), 505-506, 1999
NAID 130004440064

Impairment of passive avoidance performance in SART-stressed mice and the action of drugs.

The Japanese Journal of Pharmacology 49(1), 111-117, 1989
NAID 130000832351

Related Pictures

★リンクテーブル★

リンク元	「カルピプラミン」
拡張検索	「carpipramine maleate」「carpipramine hydrochloride」

「カルピプラミン」

Carpipramine
Systematic (IUPAC) name
	1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-piperidin-1-ylpiperidine-4-carboxamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Identifiers
CAS Number	5942-95-0
ATC code	None
PubChem	CID: 2580
ChemSpider	2482
UNII	8AFK6F91EQ
ChEMBL	CHEMBL2110775
Chemical data
Formula	C28H38N4O
Molecular mass	446.62 g/mol
	SMILES O=C(N)C5(N1CCCCC1)CCN(CCCN4c2ccccc2CCc3ccccc34)CC5 ;