WordNet

a polysaccharide that is the chief constituent of all plant tissues and fibers
the univalent radical CH3- derived from methane (同)methyl_group, methyl radical

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セルロース,繊維素

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1. 成人における慢性便秘のマネージメント management of chronic constipation in adults
2. 高齢者における便秘 constipation in the older adult
3. 遺伝性感覚自律神経ニューロパチー hereditary sensory and autonomic neuropathies
4. 成人における過敏性腸症候群の治療 treatment of irritable bowel syndrome in adults
5. 裂肛：内科的マネージメント anal fissure medical management

English Journal

Optimization and characterization of gastroretentive floating drug delivery system using Box-Behnken design.

Rapolu K1, Sanka K, Vemula PK, Aatipamula V, Mohd AB, Diwan PV.Author information 1National Facilities in Engineering and Technology with Industrial Collaboration (NAFETIC) centre, University College of Pharmaceutical Sciences, Kakatiya University , Warangal, AP , India.AbstractCONTEXT: One among many strategies to prolong gastric residence time and improve local effect of the metronidazole in stomach to eradicate Helicobacter pylori in the treatment of peptic ulcer was floating drug delivery system particularly effervescent gastroretentive tablets.
Drug development and industrial pharmacy.Drug Dev Ind Pharm.2013 Dec;39(12):1928-35. doi: 10.3109/03639045.2012.699068. Epub 2012 Jul 4.
CONTEXT: One among many strategies to prolong gastric residence time and improve local effect of the metronidazole in stomach to eradicate Helicobacter pylori in the treatment of peptic ulcer was floating drug delivery system particularly effervescent gastroretentive tablets.OBJECTIVE: The objective
PMID 22762132

ISOLATION, SCREENING AND PRODUCTION STUDIES OF URICASE PRODUCING BACTERIA FROM POULTRY SOURCES.

Nanda P1, Babu PE.Author information 1a Department of Chemical Engineering , National Institute of Technology Karnataka, Srinivasnagar , Surathkal , Karnataka , 575 025 , India.AbstractUricase (Urate oxidase E.C.1.7.3.3) is a therapeutic enzyme, which is widely used to catalyze the enzymatic oxidation of uric acid in the treatment of hyperuricemia and gout diseases. In this present study, three bacterial species capable of producing extracellular uricase were isolated from poultry source and screened based on the size of the clear zone using uric acid agar plate. Bacterial species capable of producing uricase with highest uricolytic activity was identified as Bacillus cereus strain DL3 using 16SrRNA gene sequencing approach. The time course study of uricase production was performed and the medium was optimized. Carboxy methylcellulose and asparagine were found to be the best carbon and nitrogen sources. Maximum uricolytic activity was observed at pH of 7.0 with an inducer concentration of 2.0 g/L. Inoculum size of 5--% gave maximum uricolytic activity. The maximum uricolytic activity of 15.43 U/mL was achieved at optimized conditions, which is 1.61 times more than the initial activity. Further, enzymatic stability was determined at different pH and temperature.
Preparative biochemistry & biotechnology.Prep Biochem Biotechnol.2013 Nov 26. [Epub ahead of print]
Uricase (Urate oxidase E.C.1.7.3.3) is a therapeutic enzyme, which is widely used to catalyze the enzymatic oxidation of uric acid in the treatment of hyperuricemia and gout diseases. In this present study, three bacterial species capable of producing extracellular uricase were isolated from poultry
PMID 24279683

Spray drying formulation of albendazole microspheres by experimental design. In vitro-in vivo studies.

García A1, Leonardi D, Piccirilli GN, Mamprin ME, Olivieri AC, Lamas MC.Author information 1IQUIR - CONICET .AbstractAbstract Both an experimental design and optimization techniques were carried out for the development of chitosan-pectin-carboxymethylcellulose microspheres to improve the oral absorption of albendazole as a model drug. The effect of three different factors (chitosan, pectin and carboxy methyl cellulose concentrations) was studied on five responses: yield, morphology, dissolution rate at 30 and 60 min, and encapsulation efficiency of the microspheres. During the screening phase, the factors were evaluated in order to identify those which exert a significant effect. Simultaneous multiple response optimizations were then used to find out experimental conditions where the system shows the most adequate results. The optimal conditions were found to be: chitosan concentration, 1.00% w/v, pectin concentration 0.10% w/v and carboxymethylcellulose concentration 0.20% w/v. The bioavailability of the loaded drug in the optimized microspheres was evaluated in Wistar rats which showed an area under curve (AUC) almost 10 times higher than the pure drug.
Drug development and industrial pharmacy.Drug Dev Ind Pharm.2013 Nov 18. [Epub ahead of print]
Abstract Both an experimental design and optimization techniques were carried out for the development of chitosan-pectin-carboxymethylcellulose microspheres to improve the oral absorption of albendazole as a model drug. The effect of three different factors (chitosan, pectin and carboxy methyl cellu
PMID 24237328