English Journal

Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?

Rochette L, Lorin J, Zeller M, Guilland JC, Lorgis L, Cottin Y, Vergely C.SourceLaboratoire de Physiopathologie et Pharmacologies Cardio-Métaboliques (LPPCM), France. Electronic address: luc.rochette@u-bourgogne.fr.
Pharmacology & therapeutics.Pharmacol Ther.2013 Dec;140(3):239-57. doi: 10.1016/j.pharmthera.2013.07.004. Epub 2013 Jul 13.
Nitric oxide (NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO synthase isoforms, iNOS, eNOS and nNOS. The synthesis of NO is selectively inhibited by guanidino-substituted analogs of l-Arg or methylarginines such as asymmetric dimethylarginine (ADMA), which results from protein
PMID 23859953

Chloroacetonitrile and N,2-Dichloroacetamide Formation from the Reaction of Chloroacetaldehyde and Monochloramine in Water.

Kimura SY, Komaki Y, Plewa MJ, Mariñas BJ.SourceDepartment of Civil and Environmental Engineering, ‡Department of Crop Science, and §Science and Technology Center for Advanced Materials for the Purification of Water with Systems, University of Illinois at Urbana-Champaign , Urbana-Champaign, Illinois 61801, United States.
Environmental science & technology.Environ Sci Technol.2013 Oct 23. [Epub ahead of print]
Combined chlorine is increasingly being used as an alternative disinfectant to free chlorine to maintain a residual in drinking water distribution systems mainly because it would reduce the formation of regulated disinfection byproducts (DBPs) trihalomethanes and haloacetic acids. However, the use o
PMID 24147580

Exploration of Alternate Catalytic Mechanisms and Optimization Strategies for Retroaldolase Design.

Bjelic S, Kipnis Y, Wang L, Pianowski Z, Vorobiev S, Su M, Seetharaman J, Xiao R, Kornhaber G, Hunt JF, Tong L, Hilvert D, Baker D.SourceDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Journal of molecular biology.J Mol Biol.2013 Oct 23. pii: S0022-2836(13)00655-4. doi: 10.1016/j.jmb.2013.10.012. [Epub ahead of print]
Designed retroaldolases have utilized a nucleophilic lysine to promote carbon-carbon bond cleavage of β-hydroxy-ketones via a covalent Schiff base intermediate. Previous computational designs have incorporated a water molecule to facilitate formation and breakdown of the carbinolamine intermediate
PMID 24161950

Japanese Journal

Jorunnamycins A-C, New Stabilized Renieramycin-Type Bistetrahydroisoquinolines Isolated from the Thai Nudibranch Jorunna funebris

Charupant Kornvika,Suwanborirux Khanit,Amnuoypol Surattana [他],SAITO Emi,KUBO Akinori,SAITO Naoki
Chemical & pharmaceutical bulletin 55(1), 81-86, 2007-01-01
… The chemical stability and the oxidative degradation generating simple isoquinoline alkaloids of a carbinolamine analog 1d, which was easily prepared by reacting 1c with silver nitrate in aqueous acetonitrile, are discussed. …
NAID 110006151438

Mutations in the BH4-metabolizing genes GTP cyclohydrolase I,6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase