English Journal

Structural and functional consequences of cardiac troponin C L57Q and I61Q Ca(2+)-desensitizing variants.

Wang D, McCully ME, Luo Z, McMichael J, Tu AY, Daggett V, Regnier M.SourceDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Archives of biochemistry and biophysics.Arch Biochem Biophys.2013 Jul 1;535(1):68-75. doi: 10.1016/j.abb.2013.02.006. Epub 2013 Feb 28.
Two cTnC variants, L57Q and I61Q, both of which are located on helix C within the N domain of cTnC, were originally reported in the skeletal muscle system [Tikunova, Davis, J. Biol. Chem. 279 (2004) 35341-35352], as the analogous L58Q and I62Q sTnC, and demonstrated a decreased Ca(2+) binding affini
PMID 23454346

Structural and kinetic effects of hypertrophic cardiomyopathy related mutations R146G/Q and R163W on the regulatory switching activity of rat cardiac troponin I.

Zhou Z, Rieck D, Li KL, Ouyang Y, Dong WJ.SourceDepartment of Veterinary and Comparative Anatomy Pharmacology and Physiology, Washington State University, Pullman, WA 99164, USA.
Archives of biochemistry and biophysics.Arch Biochem Biophys.2013 Jul 1;535(1):56-67. doi: 10.1016/j.abb.2012.12.007. Epub 2012 Dec 13.
Mutations in cardiac troponin I (cTnI) that cause hypertrophic cardiomyopathy (HCM) have been reported to change the contractility of cardiac myofilaments, but the underlying molecular mechanism remains elusive. In this study, Förster resonance energy transfer (FRET) was used to investigate the spe
PMID 23246786

The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits magnesium binding to the C-domain of cardiac troponin C.

Fuchs F, Grabarek Z.SourceBoston Biomedical Research Institute, 64 Grove Street, Watertown, MA, 02472-2829, USA.
Journal of muscle research and cell motility.J Muscle Res Cell Motil.2013 May;34(2):107-13. doi: 10.1007/s10974-013-9338-9. Epub 2013 Feb 18.
Cardiac muscle contraction is activated via the single Ca(2+)-binding site (site II) in the N-domain of troponin C (cTnC). The two Ca(2+)/Mg(2+) binding sites in the C-domain of cTnC (sites III and IV) have been considered to play a purely structural role in anchoring cTnC to the thin filament. Howe
PMID 23417789

Japanese Journal

Conditional Antisense-Knockdown of Zebrafish Cardiac Troponin C as a New Animal Model for Dilated Cardiomyopathy

Circulation journal : official journal of the Japanese Circulation Society 73(9), 1691-1697, 2009-08-20
NAID 10025935055

Differential pH Effect on Calcium-Induced Conformational Changes of Cardiac Troponin C Complexed with Cardiac and Fast Skeletal Isoforms of Troponin I and Troponin T