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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/03 00:58:00」(JST)

English Journal

Augmented antihypertensive effect of a fixed combination formula of candesartan and hydrochlorothiazide combined with furosemide in a patient on peritoneal dialysis.

Kuriyama S, Otsuka Y, Ueda H, Sugano N, Yoshizawa T, Yamada T, Hosoya T.SourceDivision of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan kuriyamas218@yahoo.co.jp
Clinical and experimental nephrology.Clin Exp Nephrol.2011 Feb;15(1):175-8. Epub 2010 Oct 20.
A 38-year-old female patient on peritoneal dialysis (PD) due to type 1 diabetic nephropathy with a well-preserved residual renal function did not respond well to the conventional antihypertensive therapy consisting of candesartan, furosemide, and bunazosin. Switching candesartan for a fixed combinat
PMID 20960021

Restraint stress induces connexin-43 translocation via α-adrenoceptors in rat heart.

Unuma K, Shintani-Ishida K, Yahagi N, Tsushima K, Shimosawa T, Ueyama T, Yoshida K.SourceDepartment of Forensic Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Circulation journal : official journal of the Japanese Circulation Society.Circ J.2010 Nov;74(12):2693-701. Epub 2010 Oct 19.
BACKGROUND: Immobilization (IMO) confers emotional stress in animals and humans. It was recently reported that IMO in rats induced translocation of connexin-43 (Cx43) to gap junctions (GJs) and attenuated arrhythmogenesis with GJ inhibition, and Cx43 translocation in the ischemic heart was also show
PMID 20966593

Restraint Stress Induces Connexin-43 Translocation via α-Adrenoceptors in Rat Heart

UNUMA Kana,SHINTANI ISHIDA Kaori,YAHAGI Naoki,TSUSHIMA Kensuke,SHIMOSAWA Tatsuo,UEYAMA Takashi,YOSHIDA Ken-ichi
Circulation journal : official journal of the Japanese Circulation Society 74(12), 2693-2701, 2010-11-25
… IMO induced translocation of Cx43 to the GJ-enriched membrane fraction, with a peak at 60min. The IMO-induced Cx43 translocation was inhibited by pretreatment with the α1-adrenoceptor blockers, prazosin (1mg/kg, PO) and bunazosin (4mg/kg, PO), but not with either the β1-blocker, metoprolol (10mg/kg, IP), or the β1+2-blocker, propranolol (1mg/kg, PO). …
NAID 10027424654

リンク元	「ブナゾシン」
拡張検索	「bunazosin hydrochloride」

Bunazosin
Systematic (IUPAC) name
	1-(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl)butan-1-one
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	80755-51-7
ATC code	None
PubChem	CID 2472
ChemSpider	2378
UNII	9UUW4V7G2H
ChEMBL	CHEMBL188185
Chemical data
Formula	C19H27N5O3
Molar mass	373.44 g/mol
	SMILES CCCC(=O)N1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC ;
	InChI InChI=1S/C19H27N5O3/c1-4-6-17(25)23-7-5-8-24(10-9-23)19-21-14-12-16(27-3)15(26-2)11-13(14)18(20)22-19/h11-12H,4-10H2,1-3H3,(H2,20,21,22) ; Key:RHLJLALHBZGAFM-UHFFFAOYSA-N ;
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