ブナゾシン
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- bunazosin hydrochloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/03 00:58:00」(JST)
[Wiki en表示]
Bunazosin
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Systematic (IUPAC) name |
1-(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl)butan-1-one
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Identifiers |
CAS Number |
80755-51-7 |
ATC code |
None |
PubChem |
CID 2472 |
ChemSpider |
2378 Y |
UNII |
9UUW4V7G2H Y |
ChEMBL |
CHEMBL188185 Y |
Chemical data |
Formula |
C19H27N5O3 |
Molar mass |
373.44 g/mol |
SMILES
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CCCC(=O)N1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
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InChI
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InChI=1S/C19H27N5O3/c1-4-6-17(25)23-7-5-8-24(10-9-23)19-21-14-12-16(27-3)15(26-2)11-13(14)18(20)22-19/h11-12H,4-10H2,1-3H3,(H2,20,21,22) Y
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Key:RHLJLALHBZGAFM-UHFFFAOYSA-N Y
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(verify) |
Bunazosin (INN) is an alpha 1 antagonist. Bunazosin was initially developed to treat benign prostatic hyperplasia (BPH). It has been approved in Japan in a topical form to treat glaucoma. The mechanism of action is a reduction of aqueous outflow through the uveoscleral pathway resulting in lowering the intraocular pressure. It also may act to improve blood flow to the ocular nerve. Systemic Alpha-1 adrenergic receptor antagonists have been implicated in Intraoperative Floppy Iris Syndrome (IFIS). Bunazosin potentially could have the same effect but there has been no research to substantiate this as a risk for cataract surgery.
English Journal
- Augmented antihypertensive effect of a fixed combination formula of candesartan and hydrochlorothiazide combined with furosemide in a patient on peritoneal dialysis.
- Kuriyama S, Otsuka Y, Ueda H, Sugano N, Yoshizawa T, Yamada T, Hosoya T.SourceDivision of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan kuriyamas218@yahoo.co.jp
- Clinical and experimental nephrology.Clin Exp Nephrol.2011 Feb;15(1):175-8. Epub 2010 Oct 20.
- A 38-year-old female patient on peritoneal dialysis (PD) due to type 1 diabetic nephropathy with a well-preserved residual renal function did not respond well to the conventional antihypertensive therapy consisting of candesartan, furosemide, and bunazosin. Switching candesartan for a fixed combinat
- PMID 20960021
- Restraint stress induces connexin-43 translocation via α-adrenoceptors in rat heart.
- Unuma K, Shintani-Ishida K, Yahagi N, Tsushima K, Shimosawa T, Ueyama T, Yoshida K.SourceDepartment of Forensic Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
- Circulation journal : official journal of the Japanese Circulation Society.Circ J.2010 Nov;74(12):2693-701. Epub 2010 Oct 19.
- BACKGROUND: Immobilization (IMO) confers emotional stress in animals and humans. It was recently reported that IMO in rats induced translocation of connexin-43 (Cx43) to gap junctions (GJs) and attenuated arrhythmogenesis with GJ inhibition, and Cx43 translocation in the ischemic heart was also show
- PMID 20966593
Japanese Journal
- Restraint Stress Induces Connexin-43 Translocation via α-Adrenoceptors in Rat Heart
- UNUMA Kana,SHINTANI ISHIDA Kaori,YAHAGI Naoki,TSUSHIMA Kensuke,SHIMOSAWA Tatsuo,UEYAMA Takashi,YOSHIDA Ken-ichi
- Circulation journal : official journal of the Japanese Circulation Society 74(12), 2693-2701, 2010-11-25
- … IMO induced translocation of Cx43 to the GJ-enriched membrane fraction, with a peak at 60min. The IMO-induced Cx43 translocation was inhibited by pretreatment with the α1-adrenoceptor blockers, prazosin (1mg/kg, PO) and bunazosin (4mg/kg, PO), but not with either the β1-blocker, metoprolol (10mg/kg, IP), or the β1+2-blocker, propranolol (1mg/kg, PO). …
- NAID 10027424654
- ブナゾシン塩酸塩点眼液 (デタントール^【○!R】0.01%点眼液) 使用成績調査における安全性および有効性の検討
- 樋口 直子,宮本 悦代,神田 佳子 [他],岡本 紳二,橋本 公子,國廣 英一,石田 智恵美,柳井 知子,福本 充
- あたらしい眼科 = Journal of the eye 26(3), 405-412, 2009-03-30
- NAID 10026254737
- 臨床報告 ラタノプロストの併用薬剤としてチモロールXE,ブリンゾラミドおよびブナゾシンの降圧効果の比較
Related Links
- ブナゾシン bunazosin 「概念」 α1受容体を選択的に遮断するもの。 prazosin bunazosin 「薬理」 α1受容体を選択的に抑制する。 特に心血管系のα1受容体に作用。 「作用」 血管拡張作用(血管拡張による血圧低下) 「適用」 本態性 ...
- 血管緊張緩和・血圧降下剤デタントール錠 (製薬会社:エーザイ株式会社)デタントールR錠 (製薬会社:エーザイ株式会社)末梢血管の交感神経α1受容体を選択的に抑えることにより、血管を広げ、血圧を下げます。 通常、本態性 ...
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