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1. 糖尿病患者の筋骨格系に生じる合併症の概要overview of the musculoskeletal complications of diabetes mellitus [show details]
… assess diabetic control, and findings regarding the relationship of musculoskeletal problems with diabetic control are conflicting . Thus, there is ongoing interest in the role of long-term diabetic control …
2. 糖尿病患者に生じる末梢血管疾患の概要overview of peripheral artery disease in patients with diabetes mellitus [show details]
…have comorbid diabetes mellitus (DM) . The prevalence of PAD may be underestimated in the diabetic population due to the asymptomatic nature of less severe PAD and the often concomitant diabetic neuropathy …
3. 妊娠していない成人の糖尿病患者に行う一般的な治療管理の概要overview of general medical care in nonpregnant adults with diabetes mellitus [show details]
…in patients with diabetic retinopathy, even if advanced. In the Early Treatment Diabetic Retinopathy Study, patients with mild to severe nonproliferative or early proliferative diabetic retinopathy had …
4. 糖尿病および遺伝的糖尿病症候群の分類classification of diabetes mellitus and genetic diabetic syndromes [show details]
…polygenic risk factors. The etiologic classification of diabetes mellitus will be reviewed here. The definition and diagnostic criteria for diabetes mellitus are discussed separately. Type 1 diabetes is characterized …
5. 糖尿病患者への麻酔anesthesia for patients with diabetes mellitus [show details]
…important cause of mortality and morbidity in patients with diabetes mellitus. Diabetes is an independent major risk factor for stroke; diabetic patients have approximately twice the risk of ischemic stroke …

English Journal

Failure to detect synergy between variants in transferrin and hemochromatosis and Alzheimer's disease in large cohort.

Vance E, Gonzalez Murcia JD, Miller JB, , Staley L, Crane PK, Mukherjee S, Kauwe JSK.
Neurobiology of aging. 2020 May;89()142.e9-142.e12.
Alzheimer's disease (AD) is the most common cause of dementia and, despite decades of effort, there is no effective treatment. In the last decade, many association studies have identified genetic markers that are associated with AD status. Two of these studies suggest that an epistatic interaction b
PMID 32143980

Inherited iron overload disorders.

Piperno A, Pelucchi S, Mariani R.
Translational gastroenterology and hepatology. 2020 ;5()25.
Hereditary iron overload includes several disorders characterized by iron accumulation in tissues, organs, or even single cells or subcellular compartments. They are determined by mutations in genes directly involved in hepcidin regulation, cellular iron uptake, management and export, iron transport
PMID 32258529

Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2.

Ristic B, Sivaprakasam S, Narayanan M, Ganapathy V.
The Biochemical journal. 2020 Apr;().
Hereditary hemochromatosis (HH) is mostly caused by mutations in the iron-regulatory gene HFE. The disease is associated with iron overload, resulting in liver cirrhosis/cancer, cardiomegaly, kidney dysfunction, diabetes, and arthritis. Fe2+-induced oxidative damage is suspected in the etiology of t
PMID 32239172

Related Links

Hemochromatosis - Bronze Diabetes - Symptoms, Diagnosis ...

Hemochromatosis is a condition in which the body absorbs excess iron from food. The condition is caused by a faulty gene and can lead to gradual damage to a number of organs. Hemochromatosis is sometimes referred to as bronze diabetes because it can lead to darkening of the skin and hyperglycemia Symptoms The symptoms of […]

Bronze diabetes | definition of bronze diabetes by Medical ...

bronze diabetes A clinically distinct form of DM associated with hemochromatosis, in which there are yellow-red hemosiderin deposits in the skin, liver and heart and other organs, eventually leading to renal failure, death Clinical

bronzed diabetesの意味 - 英ナビ!辞書英和辞典

pathology in which iron accumulates in the tissues; characterized by bronzed skin and enlarged liver and diabetes mellitus and abnormalities of the pancreas and the joints. 鉄分が組織に蓄積する病理。小麦色の皮膚、拡大した