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- 関
- bromisovalum、bromovalerylurea
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/07 15:08:30」(JST)
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Bromisoval
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| Names |
| IUPAC name
(RS)-2-Bromo-N-carbamoyl-3-methylbutanamide[citation needed]
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| Identifiers |
| ATC code |
N05CM03 |
|
CAS Registry Number
|
496-67-3 Y
27109-49-5 R Y |
| ChEBI |
CHEBI:31304 |
| ChEMBL |
ChEMBL1515611 Y |
| ChemSpider |
2353 Y
129594 R Y
643139 S Y |
| EC number |
207-825-7 |
InChI
-
InChI=1S/C6H11BrN2O2/c1-3(2)4(7)5(10)9-6(8)11/h3-4H,1-2H3,(H3,8,9,10,11) Y
Key: CMCCHHWTTBEZNM-UHFFFAOYSA-N Y
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| Jmol-3D images |
Image
Image |
| KEGG |
D01391 |
| MeSH |
Bromisovalum |
| PubChem |
2447
146955 R
735997 S |
SMILES
-
CC(C)C(Br)c(:[o]):[nH]:c(:[nH2]):[o]
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CC(C)C(Br)C(=O)NC(N)=O
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| UNII |
469GW8R486 Y |
| Properties |
|
Molecular formula
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C6H11BrN2O2 |
| Molar mass |
223.07 g·mol−1 |
| log P |
1.057 |
| Acidity (pKa) |
10.536 |
| Basicity (pKb) |
3.461 |
| Pharmacology |
|
Routes of
administration
|
Oral |
| Related compounds |
|
Related ureas
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Carbromal |
|
Related compounds
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- 3-Ureidopropionic acid
- beta-Ureidoisobutyric acid
- Carbamoyl aspartic acid
- N-Acetylaspartic acid
- Aceglutamide
- N-Acetylglutamic acid
- Citrulline
|
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
|
| Infobox references |
|
|
Bromisoval (INN; commonly known as bromvalerylurea) is a hypnotic and sedative discovered by Knoll in 1907 and patented in 1909.[1] It is marketed over the counter in Asia under various trade names (such as Brovarin[2]), usually in combination with non-steroidal anti-inflammatory drugs.
Chronic use of bromisoval has been associated with bromine poisoning.[3][4][5][6]
See also
References
- ^ US patent 914518, Saam, E., "Alpha-halogen-isovaleryl-urea and process of making the same", issued 1909-03-09, assigned to Knoll
- ^ "Bromisoval". International. Drugs.com.
- ^ Hashida, H.; Honda, T.; Morimoto, H.; Aibara, Y. (2001). "市販鎮痛剤常用量の服用による慢性ブロム中毒の1例" [A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia] (pdf). Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics (in Japanese) 38 (5): 700–703. doi:10.3143/geriatrics.38.700. ISSN 0300-9173. PMID 11605223. edit
- ^ Kawakami, T.; Takiyama, Y.; Yanaka, I.; Taguchi, T.; Tanaka, Y.; Nishizawa, M.; Nakano, I. (1998). "Chronic bromvalerylurea intoxication: Dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse" (pdf). Internal Medicine (Tokyo, Japan) 37 (9): 788–791. doi:10.2169/internalmedicine.37.788. PMID 9804091. edit
- ^ Wang, Y. -T.; Yang, S. Y.; Wu, V. C.; Wu, K. D.; Fang, C. C. (2005). "Pseudohyperchloraemia due to bromvalerylurea abuse". Nephrology Dialysis Transplantation 20 (8): 1767–1768. doi:10.1093/ndt/gfh945. PMID 15972320. edit
- ^ Arai, A.; Sato, M.; Hozumi, I.; Matsubara, N.; Tanaka, K.; Soma, Y.; Adachi, T.; Tsuji, S. (1997). "Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning" (pdf). Internal Medicine (Tokyo, Japan) 36 (10): 742–746. doi:10.2169/internalmedicine.36.742. PMID 9372340. edit
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Hypnotics/sedatives (N05C)
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|
| GABAA |
|
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GABAB
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- 1,4-Butanediol
- Aceburic acid
- GABOB
- GHB (sodium oxybate)
- GBL
- GVL
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|
| H1 |
| Antihistamines |
- Captodiame
- Cyproheptadine
- Diphenhydramine
- Doxylamine
- Hydroxyzine
- Methapyrilene
- Pheniramine
- Promethazine
- Propiomazine
|
|
| Antidepressants |
- Tricyclic antidepressants
- Amitriptyline
- Doxepin
- Trimipramine, etc.
- Tetracyclic antidepressants
- Mianserin
- Mirtazapine, etc.
|
|
| Antipsychotics |
- Typical antipsychotics
- Chlorpromazine
- Thioridazine, etc.
- Atypical antipsychotics
- Olanzapine
- Quetiapine
- Risperidone, etc.
|
|
|
| α2-Adrenergic |
- Clonidine
- Detomidine
- Dexmedetomidine
- Lofexidine
- Medetomidine
- Romifidine
- Tizanidine
- Xylazine
|
|
| 5-HT2A |
| Antidepressants |
- Trazodone
- Tricyclic antidepressants
- Amitriptyline
- Doxepin
- Trimipramine, etc.
- Tetracyclic antidepressants
- Mianserin
- Mirtazapine, etc.
|
|
| Antipsychotics |
- Typical antipsychotics
- Chlorpromazine
- Thioridazine, etc.
- Atypical antipsychotics
- Olanzapine
- Quetiapine
- Risperidone, etc.
|
|
| Others |
|
|
|
| Melatonin |
- Agomelatine
- Melatonin
- Ramelteon
- Tasimelteon
|
|
| Orexin |
- Almorexant
- Filorexant
- Suvorexant
|
|
| Others |
- Acecarbromal
- Apronal
- Bromisoval
- Cannabidiol
- Carbromal
- Diethylpropanediol
- Embutramide
- Evoxine
- Fenadiazole
- Gabapentin
- Kavalactones
- Mephenoxalone
- Metaglycodol
- Niaprazine
- Opioids
- Passion flower
- Phenaglycodol
- Scopolamine
- UMB68
- Valnoctamide
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|
Index of psychology and psychiatry
|
|
| Description |
|
|
| Disorders |
- Mental and behavioral
- Mood
- Developmental
- pervasive
- dyslexia and specific
- Substance-related
- Emotional and behavioral
- Symptoms and signs
- Evaluation and testing
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|
| Treatment |
- Psychotherapy
- Drugs
- depression
- antipsychotics
- anxiety
- dementia
- hypnotics and sedatives
- psychostimulants, ADHD and nootropics
|
|
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English Journal
- Maculopapular-type drug eruption caused by Coughcode(®)-N combination tablets.
- Yokose C1, Nakai N, Katoh N.
- Allergology international : official journal of the Japanese Society of Allergology.Allergol Int.2013 Dec;62(4):519-21. doi: 10.2332/allergolint.13-LE-0558. Epub 2013 Sep 25.
- PMID 24060762
- Psychosis associated with bromvalerylurea abuse in a patient with traumatic brain injury.
- Kuo CY, Liu CM, Chang LR.
- General hospital psychiatry.Gen Hosp Psychiatry.2012 May-Jun;34(3):e3-4. doi: 10.1016/j.genhosppsych.2011.10.010. Epub 2011 Dec 9.
- PMID 22154658
- [Q & A. A patient brought in a comatose state, displaying acute hepatic disorder and an area of high absorption in the stomach in CT images].
- Tanaka M, Sasaki Y.
- Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.Nihon Shokakibyo Gakkai Zasshi.2011 Apr;108(4):665-6, 669.
- PMID 21696021
Japanese Journal
- Three cases of chronic bromisoval intoxication : Clinical symptoms and application of energy dispersive X-ray analysis (EDX) to detect bromide in serum, urine and cerebrospinal fluid.
Related Links
- Find quality suppliers and manufacturers of Bromisovalfor price inquiry.where to buy Bromisoval.Also offer free database of Bromisoval including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula ...
- Bromisoval (INN; commonly known as bromvalerylurea) is a hypnotic and sedative discovered by Knoll in 1907 and patented in 1909. [1] It is marketed over the counter in Asia under various trade names (such as Brovarin [2]. [3] ...
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ブロムワレリル尿素、ブロモワレリル尿素、ブロムバレリル尿素
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- bromisoval、bromisovalum
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- bromisoval
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ブロムイソバルム
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- bromisoval、bromovalerylurea
