WordNet

turn or become green; "The trees are greening"
green color or pigment; resembling the color of growing grass (同)greenness, viridity
an area of closely cropped grass surrounding the hole on a golf course; "the ball rolled across the green and into the bunker" (同)putting_green, putting surface
of the color between blue and yellow in the color spectrum; similar to the color of fresh grass; "a green tree"; "green fields"; "green paint" (同)greenish, light-green, dark-green
not fully developed or mature; not ripe; "unripe fruit"; "fried green tomatoes"; "green wood" (同)unripe, unripened, immature
concerned with or supporting or in conformity with the political principles of the Green Party
looking pale and unhealthy; "youre looking green"; "green around the gills"
United States labor leader who was president of the American Federation of Labor from 1924 to 1952 and who led the struggle with the Congress of Industrial Organizations (1873-1952) (同)William Green
a river that rises in western Wyoming and flows southward through Utah to become a tributary of the Colorado River (同)Green River
an environmentalist who belongs to the Green Party
any of various leafy plants or their leaves and stems eaten as vegetables (同)green, leafy vegetable

PrepTutorEJDIC

『緑の,緑色の』,青々とした / (季節が)新緑の;(木々の緑が残って)温暖な / (果物が)うれていない;(酒・チーズなどが)熟成していない / 未経験の / (食物・木材・皮などが)生の;調理して(乾燥して,なめして)ない / 青野菜の;青草の / 活気のある,元気な;若い / (記億などが)生々しい / 〈U〉『緑色』;緑色の服[地];〈C〉緑色の絵の具 / 〈C〉草地,緑地,芝;(町・村の)芝の生えた共有地 / 〈C〉《複数形で》《米》装飾用の緑葉(緑枝);野菜,青物 / 〈C〉(ゴルフの)グリーン(芝を短く刈ったパット区域)
青りんご

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/24 05:19:57」(JST)

wiki en

Bromocresol green (BCG) is a dye of the triphenylmethane family (triarylmethane dyes). It is used as a pH indicator in applications such as growth mediums for microorganisms and titrations.

Bromocresol green (pH indicator)
below pH 3.8		above pH 5.4
3.8	⇌	5.4

Properties

In aqueous solution, bromocresol green will ionize to give the monoanionic form (yellow), that further deprotonates at higher pH to give the dianionic form (blue),^[4] which is stabilized by resonance:

The acid dissociation constant (pK_a) of this reaction is 4.8.^[5]

The acid and basic forms of this dye have an isosbestic point in their UV-Visible spectrum, around 515 nm, indicate that the two forms interconvert directly without forming any other substance.

Absorbance spectrum of bromocresol green at different pH values. The isosbestic point occurs where the acid and basic forms and mixtures thereof have the same absorbance

An ethanol solution (0.04 wt%) of bromocresol green has been proposed for TLC staining and is suitable for visualisation of the compounds with functional groups whose pK_a is below 5.0 (carboxylic acids, sulfonic acids, etc.). These appear as yellow spots on a light or dark blue background; no heating is necessary. Bromophenol blue solution can be used for the same purpose.

The compound is synthesized by bromination of cresol purple (m-cresolsulfonphthalein).

Uses

It is used as a pH indicator and as a tracking dye for DNA agarose gel electrophoresis. It can be used in its free acid form (light brown solid), or as a sodium salt (dark green solid). It is also an inhibitor of the prostaglandin E₂ transport protein.

Safety

Bromocresol green may cause irritation. Skin and eye contact should be avoided.

References

^ http://chemicalland21.com/specialtychem/finechem/BROMOCRESOL%20GREEN.htm
^ Kolthoff, I.M. Treatise on Analytical Chemistry, New York, Interscience Encyclopedia, Inc., 1959.
^ ^a ^b "Bromocresol Green". Sigma Aldrich.
^ Fred Senese. "Acid-Base Indicators". Frostburg State University Dept. of Chemistry.
^ Diamond, D.; Lau, K. T.; Brady, S.; Cleary, J. (2008). "Integration of analytical measurements and wireless communications—Current issues and future strategies". Talanta. 75 (3): 606. doi:10.1016/j.talanta.2007.11.022.

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5. 限局性結腸病変に対する点墨およびその他の方法 tattooing and other methods for localizing colonic lesions

English Journal

Estimation of postmortem interval through albumin in CSF by simple dye binding method.

Parmar AK1, Menon SK2.
Science & justice : journal of the Forensic Science Society.Sci Justice.2015 Dec;55(6):388-93. doi: 10.1016/j.scijus.2015.07.005. Epub 2015 Aug 14.
Estimation of postmortem interval is a very important question in some medicolegal investigations. For the precise estimation of postmortem interval, there is a need of a method which can give accurate estimation. Bromocresol green (BCG) is a simple dye binding method and widely used in routine prac
PMID 26654072

Serum albumin is associated with peripheral nerve function in patients with type 2 diabetes.

Li L1, Liu B2, Lu J1, Jiang L3, Zhang Y4, Shen Y2, Wang C5, Jia W1.
Endocrine.Endocrine.2015 Nov;50(2):397-404. doi: 10.1007/s12020-015-0588-8. Epub 2015 Apr 10.
The aim of this study is to investigate the association between serum albumin concentrations and nerve conduction (NC) parameters in Chinese patients with type 2 diabetes (T2DM). A total of 409 T2DM patients were enrolled between October 2010 and April 2014. All participants underwent nerve conducti
PMID 25860885

SIMPLE, SENSITIVE AND SELECTIVE SPECTROPHOTOMETRIC ASSAY OF NAPROXEN IN PURE, PHARMACEUTICAL PREPARATION AND HUMAN SERUM SAMPLES.

Alizadeh N, Keyhanian F.
Acta poloniae pharmaceutica.Acta Pol Pharm.2015 Sep-Oct;72(5):867-75.
Two simple, rapid and sensitive spectrophotometric methods have been developed for the determination of naproxen in pure, pharmaceutical preparation and human serum samples. These methods are based on the formation of yellow ion-pair complexes between naproxen and two sulfophthalein acid dyes, namel
PMID 26665392

Japanese Journal

クロムアズロールS類似色素の吸収及び蛍光スペクトルに及ぼすヒト血清アルブミンの影響

斎藤寛 [他],岩崎くみ子,御舩正樹,奥田秀毅,尾堂順一,田中善正
分析化学 35(12), 987-990, 1986-12-05
… The results indicate that carboxyl group is essential to form an analytically valuable dye-HSA complex in contrast with the case of Bromcresol Green-HSA complex. …
NAID 110002909277

A Sensitive Spectrofluorimetric Method for the determination of Human Serum Albumin with Chrome-azurol S

斎藤寛,岡崎(位田) 由紀子,矢野(和田) 昌子,金綱敦子,奥田秀毅,宮崎啓一,御船正樹,尾堂順一,田中善正
Chemical & pharmaceutical bulletin 34(7), 2880-2884, 1986-07-25
… The method requires less than one-thirtieth of the amount of HSA required by the control bromcresol green method. … HSA values in control sera and spinal fluid assayed by the new method were in agreement with those obtained by the control bromcresol green method. …
NAID 110003626477

A sensitive Spectrophotometric Method for the Determination of Human Serum Albumin with Chrome-azurol S Aluminium Chelate

斎藤寛,金綱敦子,奥田秀毅,御船正樹,尾堂順一,田中善正
Chemical & pharmaceutical bulletin 34(2), 746-750, 1986-02-25
… The sensitivity of the present method was about eight times that of a bromcresol green control method. …
NAID 110003626145

「ブロムクレゾールグリーン」

Bromocresol green
Names
	IUPAC name 2,6-Dibromo-4-[7-(3,5-dibromo-4-hydroxy-2-methyl-phenyl)-9,9-dioxo-8-oxa-9λ6-thiabicyclo[4.3.0]nona-1,3,5-trien-7-yl]-3-methyl-phenol
	Other names 3,3′,5,5′-Tetrabromo-m-cresolsulfonphthalein; Bromcresol green
Identifiers
CAS Number	76-60-8
3D model (Jmol)	Interactive image
Abbreviations	BCG
ChEMBL	ChEMBL145704
ChemSpider	6209
ECHA InfoCard	100.000.885
IUPHAR/BPS	4530
PubChem	6451
	InChI InChI=1S/C21H14Br4O5S/c1-9-12(7-14(22)19(26)17(9)24)21(13-8-15(23)20(27)18(25)10(13)2)11-5-3-4-6-16(11)31(28,29)30-21/h3-8,26-27H,1-2H3 Key: FRPHFZCDPYBUAU-UHFFFAOYSA-N ; InChI=1/C21H14Br4O5S/c1-9-12(7-14(22)19(26)17(9)24)21(13-8-15(23)20(27)18(25)10(13)2)11-5-3-4-6-16(11)31(28,29)30-21/h3-8,26-27H,1-2H3 Key: FRPHFZCDPYBUAU-UHFFFAOYAS ;
	SMILES Brc1cc(c(c(Br)c1O)C)C3(OS(=O)(=O)c2ccccc23)c4cc(Br)c(O)c(Br)c4C ;
Properties
Chemical formula	C21H14Br4O5S
Molar mass	698.01 g·mol−1
Appearance	Beige to brown powder
Odor	Odorless
Melting point	225 °C (437 °F; 498 K) decomposes
Solubility in water	Sparingly soluble
Solubility in other solvents	Soluble in benzene; very soluble in ethanol and diethyl ether
Acidity (pKa)	4.90
UV-vis (λmax)	423 nm
Hazards
R-phrases	R36/38
S-phrases	S24/25-S28-S37-S45
NFPA 704	1 2
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references