botch

　 　

WordNet

1. make a mess of, destroy or ruin; "I botched the dinner and we had to eat out"; "the pianist screwed up the difficult passage in the second movement" (同)bodge, bumble, fumble, botch up, muff, blow, flub, screw_up, ball up, spoil, muck up, bungle, fluff, bollix, bollix up, bollocks, bollocks up, bobble, mishandle, louse up, foul up, mess up, fuck up
2. poorly done; "a botchy piece of work"; "it was an unskillful attempt" (同)butcherly, unskillful
3. botfly larva; typically develops inside the body of a horse or sheep or human

PrepTutorEJDIC

1. 《話》…'を'ぶかっこうに繕う;…'を'やりそこなう,だいじにする《+『up』+『名』,+『名』+『up』》 / へたな繕い(仕事)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/29 20:16:00」(JST)

wiki en

[Wiki en表示]

Botch, as a verb, is nearly synonymous with "to bungle" or "to ruin".

Botch, Botched or Botcher may also refer to:

• Botch (professional wrestling), a professional wrestling slang term for missing a scripted move
• Botch (band), a mathcore/metalcore band
• Botched (film), a 2007 horror film
• Botched (TV series), an American reality television series
• Di Botcher, Welsh actress

English Journal

• Monitoring notch/delta endosomal trafficking and signaling in Drosophila.

• Loubéry S1, González-Gaitán M2.Author information 1Department of Biochemistry, Faculty of Sciences, Geneva University, Geneva, Switzerland; Department of Molecular Biology, Faculty of Sciences, Geneva University, Geneva, Switzerland.2Department of Biochemistry, Faculty of Sciences, Geneva University, Geneva, Switzerland; Department of Molecular Biology, Faculty of Sciences, Geneva University, Geneva, Switzerland. Electronic address: marcos.gonzalez@unige.ch.AbstractThe Notch signaling pathway plays important roles in many organisms and developmental contexts. The activities of the Notch receptor and of its ligand Delta are known to be regulated at several steps along the endocytic pathway. However, the precise molecular mechanism of Notch activation and the role played by endosomal sorting and trafficking remain elusive. We developed an antibody uptake assay to enable live imaging of endogenous internalized Notch and Delta in Drosophila tissues. In this chapter, we describe how to perform live antibody uptake assays in the Drosophila notum. In this tissue, Notch signaling plays a crucial role in the regulation of cell fate decisions in the lineage of sensory organ precursor (SOP) cells. We describe here how to do a correlative analysis of Notch/Delta live imaging in dividing SOPs and of the lineage of these particular SOPs. Combined with the wide range of genetic and chemical tools available in Drosophila research, these two methods will provide a better understanding of the role played by endocytic proteins and endosomal trafficking in Notch regulation, in terms of botch Notch trafficking and Notch signaling output.
• Methods in enzymology.Methods Enzymol.2014;534:301-21. doi: 10.1016/B978-0-12-397926-1.00017-2.
• The Notch signaling pathway plays important roles in many organisms and developmental contexts. The activities of the Notch receptor and of its ligand Delta are known to be regulated at several steps along the endocytic pathway. However, the precise molecular mechanism of Notch activation and the ro
• PMID 24359961

• Botch promotes neurogenesis by antagonizing Notch.

• Chi Z1, Zhang J, Tokunaga A, Harraz MM, Byrne ST, Dolinko A, Xu J, Blackshaw S, Gaiano N, Dawson TM, Dawson VL.Author information 1Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.AbstractRegulation of self-renewal and differentiation of neural stem cells is still poorly understood. Here we investigate the role of a developmentally expressed protein, Botch, which blocks Notch, in neocortical development. Downregulation of Botch in vivo leads to cellular retention in the ventricular and subventricular zones, whereas overexpression of Botch drives neural stem cells into the intermediate zone and cortical plate. In vitro neurosphere and differentiation assays indicate that Botch regulates neurogenesis by promoting neuronal differentiation. Botch prevents cell surface presentation of Notch by inhibiting the S1 furin-like cleavage of Notch, maintaining Notch in the immature full-length form. Understanding the function of Botch expands our knowledge regarding both the regulation of Notch signaling and the complex signaling mediating neuronal development.
• Developmental cell.Dev Cell.2012 Apr 17;22(4):707-20. doi: 10.1016/j.devcel.2012.02.011. Epub 2012 Mar 22.
• Regulation of self-renewal and differentiation of neural stem cells is still poorly understood. Here we investigate the role of a developmentally expressed protein, Botch, which blocks Notch, in neocortical development. Downregulation of Botch in vivo leads to cellular retention in the ventricular a
• PMID 22445366

• Toxicological findings in 889 fatally injured obese pilots involved in aviation accidents.

• Chaturvedi AK1, Botch SR, Ricaurte EM.Author information 1Aerospace Medical Research Division, Civil Aerospace Medical Institute, Federal Aviation Administration, US Department of Transportation, Oklahoma City, OK 73125-5066, USA. arvind.chaturvedi@faa.govAbstractPrevalence of drugs in fatally injured obese pilots involved in aviation accidents has not been evaluated. Therefore, toxicological findings in such pilots (body mass index ≥30 kg/m(2) ) were examined in a data set derived from the Civil Aerospace Medical Institute's (CAMI's) Scientific Information System for 1990-2005. Aeromedical histories of these aviators were retrieved from the CAMI medical certification and toxicology databases, and the cause/factors in the related accidents from the National Transportation Safety Board's database. In 311 of the 889 pilots, carbon monoxide, cyanide, ethanol, and drugs were found, and glucose and hemoglobin A(1c) were elevated. Of the 889 pilots, 107 had an obesity-related medical history. The health and/or medical condition(s) of, and/or the use of ethanol and/or drugs by, pilots were the cause/factors in 55 (18%) of the 311 accidents. Drugs found were primarily for treating obesity-related medical conditions such as depression, hypertension, and coronary heart disease.
• Journal of forensic sciences.J Forensic Sci.2012 Mar;57(2):420-6. doi: 10.1111/j.1556-4029.2011.01991.x. Epub 2011 Dec 8.
• Prevalence of drugs in fatally injured obese pilots involved in aviation accidents has not been evaluated. Therefore, toxicological findings in such pilots (body mass index ≥30 kg/m(2) ) were examined in a data set derived from the Civil Aerospace Medical Institute's (CAMI's) Scientific Informatio
• PMID 22150571

• Effects of soil cations on the foraging behavior of Reticulitermes flavipes (Isoptera: Rhinotermitidae).

• Botch PS1, Judd TM.Author information 1Department of Biology, Southeast Missouri State University, Cape Giradeau, MO 63701, USA. psbz76@mizzou.eduAbstractThis study examined soil cation concentration gradients around decomposing logs and determined whether Reticulitermes flavipes (Kollar) (Isoptera: Rhinotermitidae) builds galleries in soil substrates containing those cations versus soils without, presumably in an effort to forage efficiently. Soil samples were collected at different depths and lateral distances from decomposing logs containing termites, freshly fallen logs without termites, and bare soil locations at 10 sites to determine whether cation gradients existed in a forest floor. Analyses of cation gradients were significant for potassium, calcium, and magnesium; however, only potassium showed a significant gradient where concentrations decreased with depth and lateral distance from a decomposing log. R. flavipes was then tested in laboratory bioassays to determine if they were attracted to salt cation solutions. Linear foraging distance was significantly greater in artificial K2CO3 gradients than in controls. The results from this study suggest that potassium is found in gradients around decomposing logs and that R. flavipes is attracted to this cation.
• Journal of economic entomology.J Econ Entomol.2011 Apr;104(2):425-35.
• This study examined soil cation concentration gradients around decomposing logs and determined whether Reticulitermes flavipes (Kollar) (Isoptera: Rhinotermitidae) builds galleries in soil substrates containing those cations versus soils without, presumably in an effort to forage efficiently. Soil s
• PMID 21510189

Japanese Journal

• ダイナミック膜を用いた回分および連続濃縮プロセスの特性

• 化学工学論文集 16(1), 9-15, 1990
• NAID 130000871333

• Nonlinear Effects in the Shear Viscosity of Critical Mixtures

• 理論物理学の進歩 38(5), 1031-1051, 1967-11-25
• NAID 110001202612

• 臨界溶液におけるnonlinear shear viscosity

• 物性研究 7(6), 452-478, 1967-03-20
• NAID 110006445821

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• botchの意味・用例｜英辞郎 on the WEB：アルク

botch 【他動】～をやり損なう、しくじる、台無しにする 【名】下手な仕事、へま - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。

• Botch | Define Botch at Dictionary.com - Dictionary.com ...

Botch definition, to spoil by poor work; bungle (often followed by up): He botched up the job thoroughly. See more. ... No man ever yet undertook tew alter his natur by substituting sum invenshun ov his own, but what made a botch job ov it.

• botchの意味 - 英和辞典 - コトバンク

プログレッシブ英和中辞典(第4版) - /bt | bt/((略式))[動](他)…をだめにする, 台なしにする；…を不手ぎわにやる[修繕する]((up)). [名]((主に英))へたな仕事, やり損ない；不手ぎわに当てた継ぎ；ごた混ぜ, 寄せ集めmake a botch of ...

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