関: bopindolol malonate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/02/24 02:17:06」(JST)

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Bopindolol (INN) is a beta blocker. It is an ester which acts as a prodrug for its active metabolite 4-(3-t-butylamino-2-hydroxypropoxy)-2-methylindole.^[1]

References

^ Nagatomo T, Hosohata Y, Ohnuki T, Nakamura T, Hattori K, Suzuki J, Ishiguro M (Spring 2001). "Bopindolol: pharmacological basis and clinical implications". Cardiovasc Drug Rev. 19 (1): 9–24. doi:10.1111/j.1527-3466.2001.tb00180.x. PMID 11314603.

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English Journal

Fluorometric determination of bopindolol and celiprolol in pharmaceutical preparations and biological fluids.

Belal F, Sharaf El-Din M, Aly F, Hefnawy M, El-Awady M.SourceDepartment of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, Egypt.
Journal of fluorescence.J Fluoresc.2012 Jul;22(4):1141-50. doi: 10.1007/s10895-012-1053-1. Epub 2012 Apr 3.
Two sensitive fluorometric methods were developed for the determination of both bopindolol malonate (BOP) and celiprolol HCl (CLP) based on measuring their native fluorescence in methanol and acetonitrile, respectively. For BOP, the fluorescence was measured at 316 nm after excitation at 278 nm. T
PMID 22477063

Chiral separations of some beta-adrenergic agonists and antagonists on AmyCoat column by HPLC.

Ali I, Saleem K, Gaitonde VD, Aboul-Enein HY, Hussain I.SourceDepartment of Chemistry Jamia Millia Islamia (Central University), New Delhi 110025, India.
Chirality.Chirality.2010 Jan;22(1):24-8. doi: 10.1002/chir.20697.
Sixteen beta-adrenergic antagonists namely acebutalol, alprenolol, atenolol, bisoprolol, bopindolol, bufurolol, carazolol, celiprolol, indenolol, metaprolol, nebivolol, oxprenolol, practolol, propranolol, tertalol, and timolol, and two beta-adrenergic agonists namely cimeterol and clenbuterol were r
PMID 19208401

Role of chemical structure in stereoselective recognition of beta-blockers by cyclodextrins in capillary zone electrophoresis.

Gagyi L, Gyéresi A, Kilár F.SourceUniversity of Medicine and Pharmacy Târgu-Mureş, Institute of Pharmaceutical Chemistry, Str. Gheorghe Marinescu nr. 38, 540139 Târgu-Mureş, Romania.
Journal of biochemical and biophysical methods.J Biochem Biophys Methods.2008 Apr 24;70(6):1268-75. Epub 2007 Oct 13.
Most of the beta-blocking drugs for treating diseases of the cardiovascular system are chiral aryloxy-propanolamine derivatives. Tipically, the S(-) enantiomers are more active than the R(+) enantiomers. Only some of them (for example timolol) are used as single enantiomers, the others are employed
PMID 18022245

Japanese Journal

Different Effects of a Long-term Administration of β-blockers,Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of SpontaneouslyHypertensive Rats (SHR)

Takashi NAKAMURA,Yoshiaki HOSOHATA,Kaoru HATTORI
Acta medica et biologica 49(1), 1-4, 2001-03
… The effects of a chronic administration of a non-selective β-blocker, bopindolol, on the binding characteristics of radiolabeled CGP-12177 (^3H-CGP12177) to each β_1-and β_2-adrenoceptor subtype in the kidney of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) were determined using the radioligand binding assay method and compared with those of a β_1-selective β-blocker, atenolol. … Bopindolol (1 mg/kg/day and 3 mg/kg/day) and atenolol (50 mg/kg/day) were given to 10-week-old SHR for 12 weeks. …
NAID 110004461721

Hemodynamic Normalization Shown after Treatment with Principal Antihypertensive Drugs in Essential Hypertension

Muramatsu Jun,Kurokawa Shingo
北里医学 29(3), 123-129, 1999-06-30
… The subjects were 105 essential hypertension patients (WHO stage 1〜2) in whom a hemodynamic analysis was performed by the Wezler-Boeger method before and after treatment (6〜12 weeks) with the Ca antagonists nifedipine and nicardipine, the ACEI captopril, and the β-blockers pindolol, bopindolol, and amosulalol. …
NAID 110004698210

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リンク元	「ボピンドロール」
拡張検索	「bopindolol malonate」

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Bopindolol
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	C07AA17 (WHO);
Legal status
Legal status	℞ (Prescription only);
Identifiers
	IUPAC name (RS)-1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate;
CAS Number	69010-88-4 ;
PubChem CID	44112;
DrugBank	DB08807 ;
ChemSpider	40146 ;
UNII	KT304VZO57;
KEGG	D07537 ;
ChEMBL	CHEMBL357995 ;
Chemical and physical data
Formula	C23H28N2O3
Molar mass	380.48 g/mol
3D model (Jmol)	Interactive image;
	SMILES CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)OC(=O)C3=CC=CC=C3 ;
	InChI InChI=1S/C23H28N2O3/c1-16-13-19-20(25-16)11-8-12-21(19)27-15-18(14-24-23(2,3)4)28-22(26)17-9-6-5-7-10-17/h5-13,18,24-25H,14-15H2,1-4H3 ; Key:UUOJIACWOAYWEZ-UHFFFAOYSA-N ;
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関: bopindolol

[1] Nagatomo T, Hosohata Y, Ohnuki T, Nakamura T, Hattori K, Suzuki J, Ishiguro M (Spring 2001). "Bopindolol: pharmacological basis and clinical implications". Cardiovasc Drug Rev. 19 (1): 9–24. doi:10.1111/j.1527-3466.2001.tb00180.x. PMID 11314603.

v t e Beta blockers (C07)

β, non-selective	Alprenolol Bopindolol Bupranolol Carteolol Cloranolol Mepindolol Nadolol Oxprenolol Penbutolol Pindolol/Iodopindolol Propranolol Sotalol Tertatolol Timolol

β₁-selective	Acebutolol Atenolol Betaxolol Bevantolol Bisoprolol Celiprolol Epanolol Esmolol Landiolol Metoprolol Nebivolol Practolol S-Atenolol Talinolol

β₂-selective	Butaxamine

α₁- + β-selective	Arotinolol Carvedilol Labetalol

^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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bopindolol