English Journal

Fluorometric determination of bopindolol and celiprolol in pharmaceutical preparations and biological fluids.

Belal F1, Sharaf El-Din M, Aly F, Hefnawy M, El-Awady M.
Journal of fluorescence.J Fluoresc.2012 Jul;22(4):1141-50. doi: 10.1007/s10895-012-1053-1. Epub 2012 Apr 3.
Two sensitive fluorometric methods were developed for the determination of both bopindolol malonate (BOP) and celiprolol HCl (CLP) based on measuring their native fluorescence in methanol and acetonitrile, respectively. For BOP, the fluorescence was measured at 316 nm after excitation at 278 nm. T
PMID 22477063

Beta-blocking potency and selectivity of bopindolol and its two metabolites for beta 1- and beta 2-adrenergic receptors as assessed by radioligand binding assay.

Sakuma N1, Tsuchihashi H, Hosohata Y, Akashi H, Kinami J, Nagatomo T.
Journal of pharmacobio-dynamics.J Pharmacobiodyn.1991 May;14(5):250-5.
Using a radioligand binding assay, we assessed the affinity and selectivity of the antagonistic effects of bopindolol (4-(benzoyloxy-3-tert-butylaminopropyl)-2-methylindole hydrogen-malonate) and its two metabolites, (18-502, (4-(3-tert-butylamino-2-hydroxypropoxy)-2-methyl indole) and 20-785, (4-(3
PMID 1685186

Japanese Journal

山下樹三裕 [他],重松和人,前田哲,石田芳英,丹羽正美,尾崎正若
日本薬理学雑誌 93(1), 7-15, 1989
… β-遮断薬 bopindolol {4-(2-benzoyloxy-3-tert-butylaminopropoxy)-2-methyl-indole hydrogen malonate}の脳卒中易発症ラット(SHRSP)に対する抗高血圧作用について検討した．雄性SHRSP 8週齢より32週齢までの24週間にわたって，bopindolol 0.002% 水溶液を随時飲用水として与えた．飲水量より算出した bopindolol の投与量は約1.4mg/kg/日であった．bopindolol は SHRSP …
NAID 130000759231

金万宝 [他],孫暁東,河田登美枝,今井昭一
日本薬理学雑誌 94(1), 27-33, 1989
… β遮断薬 bopindolol(4-(2-benzoylpxy-3-tert-butylaminopropoxy)-2-methyl-indole hydrogen malonate)及びその代謝産物である 18-502(4-(3-tert-butylamino-2-hydroxypropoxy)-2-methyl indole)及び 20-785(4-(3-tert-butylaminopropoxy)-2-carboxyl indole)の β遮断作用，部分作用薬活性(partial agonist activity)，膜安定化作用につき，モルモット摘出心房標本，摘出気管平滑筋標本，中枢破壊ラット(pithed rat)及びモルモット右心室乳頭筋標本を用いて検討 …
NAID 130000759169