WordNet

marred by discolored spots or blotches; "blotchy skin"
an irregularly shaped spot (同)splodge, splotch

PrepTutorEJDIC

しみ(できもの)だらけの
大きなしみ,よごれ / 吹き出物,おでき / …'を'汚す,‘に'しみをつける

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1. 肝肺症候群：有病割合、原因、臨床症状、および診断 hepatopulmonary syndrome prevalence causes clinical manifestations and diagnosis
2. 成人における亀頭炎および亀頭包皮炎 balanitis and balanoposthitis in adults
3. 遺伝性感覚自律神経ニューロパチー hereditary sensory and autonomic neuropathies
4. 成人における腹水の診断および評価 evaluation of adults with ascites
5. アフリカ・トリパノソーマ症の臨床症状、診断、および治療 clinical manifestations diagnosis and treatment of african trypanosomiasis

English Journal

Epidemiological and clinical features of erythema infectiosum in children in Novi Sad from 2000 to 2009.

Prćić S1, Gajinov Z2, Zrnić B3, Radulović A4, Matić M2, Djuran V4.Author information 1Department of Dermatovenerology, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia. buki97@eunet.rs2Clinic of Dermatovenerology Diseases, Clinical Center of Vojvodina, Novi Sad, Serbia.3Faculty of Medicine, University of Banja Luka, Banja Luka, Republic of Srpska, Bosnia and Herzegovina.4Department of Dermatovenerology, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia.AbstractBACKGROUND/AIM: Erythema infectiosum (EI) is a common childhood illness, caused by human parvovirus B19. It occurs sporadically or in epidemics and is characterized by mild constitutional symptoms and a blotchy or maculopapular lacy rash on the cheeks (slapped-cheek) spreading primarily to the extremities and trunk. The aim of our study was to analyse the epidemiological and clinical characteristics of erythema infectiosum in children.
Vojnosanitetski pregled. Military-medical and pharmaceutical review.Vojnosanit Pregl.2013 Dec;70(12):1081-4.
BACKGROUND/AIM: Erythema infectiosum (EI) is a common childhood illness, caused by human parvovirus B19. It occurs sporadically or in epidemics and is characterized by mild constitutional symptoms and a blotchy or maculopapular lacy rash on the cheeks (slapped-cheek) spreading primarily to the extre
PMID 24450250

Sinogram-affirmed iterative reconstruction of low-dose chest CT: effect on image quality and radiation dose.

Kalra MK1, Woisetschläger M, Dahlström N, Singh S, Digumarthy S, Do S, Pien H, Quick P, Schmidt B, Sedlmair M, Shepard JA, Persson A.Author information 11 Division of Thoracic Imaging, Department of Radiology, Massachusetts General Hospital, Boston MA.AbstractOBJECTIVE. The purpose of this study is to compare sinogram-affirmed iterative reconstruction (SAFIRE) and filtered back projection (FBP) reconstruction of chest CT acquired with 65% radiation dose reduction. MATERIALS AND METHODS. In this prospective study involving 24 patients (11 women and 13 men; mean [± SD] age, 66 ± 10 years), two scan series were acquired using 100 and 40 Quality Reference mAs over a 10-cm scan length in the chest with a 128-MDCT scanner. The 40 Quality Reference mAs CT projection data were reconstructed with FBP and four settings of SAFIRE (S1, S2, S3, and S4). Six image datasets (FBP with 100 and 40 Quality Reference mAs, and S1, S2, S3, S4 with 40 Quality Reference mAs) were displayed on a DICOM-compliant 55-inch 2-megapixel monitor for blinded evaluation by two thoracic radiologists for number and location of lesions, lesion size, lesion margins, visibility of small structures and fissures, and diagnostic confidence. Objective noise and CT values were measured in thoracic aorta for each image series, and the noise power spectrum was assessed. Data were analyzed with analysis of variance and Wilcoxon signed rank tests. RESULTS. All 186 lesions were seen on 40 Quality Reference mAs SAFIRE images. Diagnostic confidence on SAFIRE images was higher than that for FBP images. Except for the minor blotchy appearance on SAFIRE settings S3 and S4, no significant artifacts were noted. Objective noise with 40 Quality Reference mAs S1 images (21.1 ± 6.1 SD of HU) was significantly lower than that for 40 Quality Reference mAs FBP images (28.5 ± 8.1 SD of HU) (p < 0.001). Noise power spectra were identical for SAFIRE and FBP with progressive noise reduction with higher iteration SAFIRE settings. CONCLUSION. Iterative reconstruction (SAFIRE) allows reducing the radiation exposure by approximately 65% without losing diagnostic information in chest CT.
AJR. American journal of roentgenology.AJR Am J Roentgenol.2013 Aug;201(2):W235-44. doi: 10.2214/AJR.12.9569.
OBJECTIVE. The purpose of this study is to compare sinogram-affirmed iterative reconstruction (SAFIRE) and filtered back projection (FBP) reconstruction of chest CT acquired with 65% radiation dose reduction. MATERIALS AND METHODS. In this prospective study involving 24 patients (11 women and 13 men
PMID 23883238

Production of LPS-induced inflammatory mediators in murine peritoneal macrophages: neocuproine as a broad inhibitor and ATP7A as a selective regulator.

Patel OV1, Wilson WB, Qin Z.Author information 1Division of Vascular Surgery, Department of Surgery, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.AbstractCopper chelation regulates the production of inflammatory mediators in vivo during vascular inflammation and atherogenesis. Little is known about how the copper egress pump ATP7A regulates the production of these mediators. In this study, we isolated ATP7A deficient macrophages (MΦ) from the peritoneal cavity of blotchy mice and identified the lipopolysaccharide (LPS)-induced inflammatory mediators that were altered by ATP7A deficiency. These results were compared with the effect of neocuproine (a copper chelator) treatment on both ATP7A deficient and control MΦ. Seven of the 24 inflammatory mediators examined in this study had significant changes in expression in the ATP7A deficient MΦ compared to controls; 16 of these mediators were significantly reduced in MΦ treated with neocuproine compared to controls. Both neocuproine treatment and ATP7A deficiency reduced IFN-γ, MCP-1, MCP-3, and VEGF-A levels. Interestingly, the production of KC/GRO was upregulated by ATP7A deficiency but downregulated by neocuproine treatment. Neocuproine, but not ATP7A deficiency, reduced the production of FGF-9, IL-1α, IL-12p70, IL-2, IL-3, IL-4, IL-6, MIP-1β, MIP-2, RANTES, and TNFα. ATP7A deficiency but not neocuproine treatment reduced IP-10 and MCP-5 levels. In addition, both ATP7A deficiency and neocuproine treatment had no effect on GM-CSF, IL-10, IL-11, IL-7, OSM, and SCF. Together, these findings provide evidence that MΦ ATP7A selectively regulates LPS-induced inflammatory mediators, in part, via modulation of cellular copper availability, whereas neocuproine generally inhibits the production of inflammatory mediators. These results also imply that although copper chelation and ATP7A downregulation may result in different copper concentrations, gradients, and/or distribution in the cells, they may not lead to opposite biological effects on inflammatory mediator production.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.Biometals.2013 Jun;26(3):415-25. doi: 10.1007/s10534-013-9624-4. Epub 2013 Apr 19.
Copper chelation regulates the production of inflammatory mediators in vivo during vascular inflammation and atherogenesis. Little is known about how the copper egress pump ATP7A regulates the production of these mediators. In this study, we isolated ATP7A deficient macrophages (MΦ) from the perito
PMID 23604539

Japanese Journal

トマト果実着色不良の発生要因と対策方法に関する研究

鈴木克己,佐々木英和,永田雅靖
野菜茶業研究所研究報告 = Bulletin of the National Institute of Vegetable and Tea Science (12), 81-88, 2013-03
果実の肩が黄色く変色した着色むらを伴った着色不良果の発生要因と，抑制技術について検討した。着色不良を生じた果実の着色不良部位のリコぺン含量は着色良好部位のそれに比べ低かった。着色不良部位の有色体では，着色良好部位に比べて，リコペン体が小さく，反対にデンプン粒が多く観察された。果実をアルミホイルで被覆し一部に直射日光が当たるように切り込みを入れたところ，切れ込み部位における着色不良割合は被覆部位より …
NAID 120005580529

Down-regulation of DR12, an auxin-response-factor homolog, in the tomato results in a pleiotropic phenotype including dark green and blotchy ripening fruit

JONES B.
Plant J. 32, 603-613, 2002
NAID 30014609068

Similar splicing mutations of the Menkes/mottled copper-transporting ATPase gene in occipital horn syndrome and the blotchy mouse

DAS S.
Am. J. Hum. Genet. 56, 570-576, 1995
NAID 10009524958

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