biosynthesis of heme

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• 1. ポルフィリン症：概要porphyrias an overview [show details]
  … are metabolic disorders caused by altered activities of one of the eight enzymes involved in heme biosynthesis The pathway starts with delta-aminolevulinic acid (ALA) synthase (ALAS), which creates ALA …
• 2. 鉄芽球性貧血の原因および病態生理causes and pathophysiology of the sideroblastic anemias [show details]
  … XLSA . Many disorders of heme synthesis are not associated with sideroblastic anemia, as discussed in the following. Porphyrias are inherited disorders of heme biosynthesis, each caused by genetic defects …
• 3. ALA脱水酵素欠損性ポルフィリン症ala dehydratase porphyria [show details]
  … expression of housekeeping and erythroid-specific transcripts evolved to ensure sufficient heme biosynthesis for the high-level tissue-specific production of hemoglobin . The promoter region upstream of …
• 4. 鉄芽球性貧血：診断とマネージメントsideroblastic anemias diagnosis and management [show details]
  …Erythropoietic protoporphyria (EPP) due to mutations in , which encodes the terminal enzyme of heme biosynthesis; Syndromic forms; Sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental …
• 5. 急性間欠性ポルフィリン症：発症機序、臨床的特徴、診断acute intermittent porphyria pathogenesis clinical features and diagnosis [show details]
  …porphyrias are presented separately. Porphyrias are caused by alterations in the enzymes of heme biosynthesis. Heme is essential in the function of many hemoproteins, including hemoglobin and hepatic cytochrome …

English Journal

• Effects of malondialdehyde as a byproduct of lipid oxidation on protein oxidation in rabbit meat.

• Wang Z, He Z, Emara AM, Gan X, Li H.
• Food chemistry. 2019 Aug;288()405-412.
• The effects of malondialdehyde (MDA) as a byproduct of lipid oxidation on myoglobin and myofibrillar proteins (MP) oxidations in muscle homogenates containing components native to rabbit muscle were investigated. For myoglobin, MDA could lead to increase in metmyoglobin percentage. For MP, MDA could
• PMID 30902311

• Heme metabolism as a therapeutic target against protozoan parasites.

• Lechuga GC, Pereira MCS, Bourguignon SC.
• Journal of drug targeting. 2019 Aug;27(7)767-779.
• Neglected tropical diseases caused by protozoan parasites affect the life of millions of people worldwide, causing mortality, morbidity and high economic and social burden. The search for new drug targets and therapeutic strategies to fight these pathogens are necessary, since many current drugs hav
• PMID 30332897

• The interrelationship between gasotransmitters and lead-induced renal toxicity in rats.

• Abdel-Zaher AO, Abd-Ellatief RB, Aboulhagag NA, Farghaly HSM, Al-Wasei FMM.
• Toxicology letters. 2019 Aug;310()39-50.
• This study explored the role of gasotransmitters in lead-induced nephrotoxicity. Long-term exposure of rats to lead resulted in its accumulation in kidney. The accumulated metal impaired kidney function and structure. Lead intoxication resulted in oxidative stress, inflammation and apoptosis in kidn
• PMID 30980911

Japanese Journal

• Metabolic comparison of aerial and submerged mycelia formed in the liquid surface culture of Cordyceps militaris

• Suparmin Ahmad,Kato Tatsuya,Takemoto Hiroyuki,Park Enoch Y.
• MicrobiologyOpen, e836, 2019-03-28
• NAID 120006600385

• グリオーマ治療と光感受性物質　～5-アミノレブリン酸を中心に～

• 山本 淳考,北川 雄大,宮岡 亮,鈴木 恒平,齋藤 健,中野 良昭
• Neuro-Oncologyの進歩 25(3), 13-21, 2019
• … <p>5-aminolevulinic acid (5-ALA) is a natural biochemical precursor of heme, which is converted by the heme synthesis pathway into protoporphyrin IX (PpIX) in mitochondria. …
• NAID 130007584775

• Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia

• Shiozawa Yusuke,Malcovati Luca,Gallì Anna,Sato-Otsubo Aiko,Kataoka Keisuke,Sato Yusuke,Watatani Yosaku,Suzuki Hiromichi,Yoshizato Tetsuichi,Yoshida Kenichi,Sanada Masashi,Makishima Hideki,Shiraishi Yuichi,Chiba Kenichi,Hellström-Lindberg Eva,Miyano Satoru,Ogawa Seishi,Cazzola Mario
• Nature Communications (9), 2018-09-07
• … Here we report transcriptomic analyses of 265 bone marrow samples from myelodysplasia patients, followed by a validation using CRISPR/Cas9-mediated gene editing and an assessment of nonsense-mediated decay susceptibility. … Small but widespread reduction of intron-retaining isoforms is the most frequent splicing alteration in SF3B1-mutated samples. …
• NAID 120006537149

Related Links

• Structure and function of enzymes in heme biosynthesis

Tetrapyrroles like hemes, chlorophylls, and cobalamin are complex macrocycles which play essential roles in almost all living organisms. Heme serves as prosthetic group of many proteins involved in fundamental ...

• Porphyrin and Heme Synthesis and Bilirubin Metabolism

The first reaction in heme biosynthesis takes place in the mitochondria and involves the condensation of one glycine and one succinyl-CoA by the pyridoxal phosphate-requiring (vitamin B 6) enzyme, δ-aminolevulinic acid synthase ...

• Review Biosynthesis of heme in mammals - MIT ...

Review Biosynthesis of heme in mammals Richard S. Ajioka, John D. Phillips, James P. Kushner⁎ Department of Internal Medicine, Division of Hematology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA

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