English Journal

Bioreductively activatable prodrug conjugates of phenstatin designed to target tumor hypoxia.

Winn BA, Shi Z, Carlson GJ, Wang Y, Nguyen BL, Kelly EM, Ross RD, Hamel E, Chaplin DJ, Trawick ML, Pinney KG.
Bioorganic & medicinal chemistry letters. 2017 02;27(3)636-641.
A variety of solid tumor cancers contain significant regions of hypoxia, which provide unique challenges for targeting by potent anticancer agents. Bioreductively activatable prodrug conjugates (BAPCs) represent a promising strategy for therapeutic intervention. BAPCs are designed to be biologically
PMID 28007448

Blurring the Role of Oligonucleotides: Spherical Nucleic Acids as a Drug Delivery Vehicle.

Tan X, Lu X, Jia F, Liu X, Sun Y, Logan JK, Zhang K.
Journal of the American Chemical Society. 2016 08;138(34)10834-7.
Nucleic acids are generally regarded as the payload in gene therapy, often requiring a carrier for intracellular delivery. With the recent discovery that spherical nucleic acids enter cells rapidly, we demonstrate that nucleic acids also have the potential to act as a delivery vehicle. Herein, we re
PMID 27522867

Bioreductive fluorescent imaging agents: applications to tumour hypoxia.

, E E, R R, R R, .
Chemical communications (Cambridge, England). 2016 Jul;52(58)8935-56.
Large tumours contain regions with very low intracellular O2 concentrations. Known as hypoxia, this feature of tumours yields a highly reducing environment owing to the presence of numerous oxygen sensitive reductase enzymes. The development of new optical chemosensors for these various reductases p
PMID 26924320

Japanese Journal

低酸素細胞特異的な蛍光イメージング剤の開発

Nakata Eiji,Yukimachi Yoshihiro,Abe Chiaki,Uto Yoshihiro,Hori Hitoshi,中田栄司,行待芳浩,阿部千秋,宇都義浩,堀均
徳島大学大学院ソシオテクノサイエンス研究部研究報告 55, 2010
We have designed and evaluated UTX-12 as a novel fluorescent pH probe for tumor hypoxiaimaging. UTX-12 consists of a p-nitro benzyl moiety, which is a latent hypoxia-selective leavinggroup activated b …
NAID 120002932248

低酸素細胞特異的な蛍光イメージング剤の開発

中田栄司,行待芳浩,阿部千秋,宇都義浩,堀均
徳島大学大学院ソシオテクノサイエンス研究部研究報告 55, 59-66, 2010
NAID 110007594198

Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging

Nakata Eiji,Yukimachi Yoshihiro,Kariyazono Hirokazu,Im Seongwang,Abe Chiaki,Uto Yoshihiro,Maezawa Hiroshi,Hashimoto Toshihiro,Okamoto Yasuko,Hori Hitoshi
BIOORGANIC & MEDICINAL CHEMISTRY 17(19), 6952-6958, 2009
NAID 120004710221

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