English Journal

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.

Anderson RF1, Yadav P, Patel D, Reynisson J, Tipparaju SR, Guise CP, Patterson AV, Denny WA, Maroz A, Shinde SS, Hay MP.
Organic & biomolecular chemistry.Org Biomol Chem.2014 Jun 7;12(21):3386-92. doi: 10.1039/c4ob00236a. Epub 2014 Apr 16.
The radical species underlying the activity of the bioreductive anticancer prodrug, SN30000, have been identified by electron paramagnetic resonance and pulse radiolysis techniques. Spin-trapping experiments indicate both an aryl-type radical and an oxidising radical, trapped as a carbon-centred rad
PMID 24737463

Lin SC1, Liao WL, Lee JC, Tsai SJ.
Experimental biology and medicine (Maywood, N.J.).Exp Biol Med (Maywood).2014 May 8. [Epub ahead of print]
Hypoxia is a common phenomenon of solid tumors and contributes to aggressive phenotype and treatment failure. Hypoxia-inducible factor (HIF), a versatile transcription factor that regulates more than 5% of total human genes, not only plays important roles in controlling physiological processes, but
PMID 24812122

Genotoxicity and cytotoxicity evaluation of oenothein B and its protective effect against mitomycin C-induced mutagenic action.

Silva CA, Silva CR, Véras JH, Chen-Chen L, Ferri PH, Santos SD.
Mutation research. Genetic toxicology and environmental mutagenesis.Mutat Res Genet Toxicol Environ Mutagen.2014 Apr 19;767C:8-12. doi: 10.1016/j.mrgentox.2014.04.003. [Epub ahead of print]
The natural product oenothein B (OeB), a dimeric macrocyclic ellagitannin, has a wide range of biological activities, such as antioxidant, anti-inflammatory, anti-viral, antifungal, and antitumor. However, investigations concerning its genotoxicity have not been carried out. This study assessed the
PMID 24751336

Japanese Journal

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery:Drug Discovery for Targeting the Tumor Microenvironment

Nagasawa Hideko
Journal of Pharmacological Sciences 115(4), 446-452, 2011
The tumor microenvironment, characterized by regions of hypoxia, low nutrition, and acidosis due to incomplete blood vessel networks, has been recognized as a major factor that influences not only the …
NAID 130000663506

玉置洸司郎,齋藤範三,荻崇,野村俊之,小西康裕
化学工学論文集 36(3), 288-292, 2010-07-20
金属イオン還元細菌Shewanella algaeの静止細胞は，ギ酸塩または乳酸塩を電子供与体として用いて，初期液相濃度1–10 mol/m3のPdCl2水溶液からパラジウムを細菌細胞内に還元・回収することができた．とくにギ酸塩を電子供与体に用いた場合には，S. algaeによるPd(II)イオンの還元は迅速に進行し，Pd(II)イオンの最大還元・回収速度は2.14×10?14 g-P …
NAID 10027040825