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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/28 14:45:42」(JST)

Biapenem (INN) is a carbapenem antibiotic. It has in vitro activity against anaerobes.^[1]

Approved in Japan in 2001.

References

^ Aldridge KE, Morice N, Schiro DD (April 1994). "In vitro activity of biapenem (L-627), a new carbapenem, against anaerobes". Antimicrob. Agents Chemother. 38 (4): 889–93. doi:10.1128/aac.38.4.889. PMC 284564. PMID 8031067.

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Electron microscopic structures, serum resistance, and plasmid restructuring of New Delhi metallo-β-lactamase-1 (NDM-1)-producing ST42 Klebsiella pneumoniae emerging in Japan.

Yamamoto T, Takano T, Fusegawa T, Shibuya T, Hung WC, Higuchi W, Iwao Y, Khokhlova O, Reva I.SourceDivision of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, tatsuoy@med.niigata-u.ac.jp.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.J Infect Chemother.2012 Sep 14. [Epub ahead of print]
Enterobacteriaceae, carrying the New Delhi metallo-β-lactamase-1 (NDM-1) gene (bla (NDM-1)), have emerged and posed a threat since 2006. In Japan, bla (NDM-1)-carrying Escherichia coli was first described in 2010. In this study, we characterized NDM-1-posit
PMID 22971935

Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes.

Livermore DM, Mushtaq S, Morinaka A, Ida T, Maebashi K, Hope R.SourceAntibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency-Colindale, London NW9 5EQ, UK.
The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2012 Sep 3. [Epub ahead of print]
OBJECTIVES: ME1071 is a maleic acid that inhibits metallo-β-lactamases (MBLs). We examined its ability to potentiate different carbapenems against MBL-producing Enterobacteriaceae in relation to its inhibition kinetics.METHODS: Enterobacteriaceae and Acinetobacter isolates with IMP, VIM and NDM MBL
PMID 22945917

In vivo efficacy and pharmacokinetics of biapenem in a murine model of ventilator-associated pneumonia with Pseudomonas aeruginosa

YAMADA Koichi,YAMAMOTO Yoshihiro,YANAGIHARA Katsunori,ARAKI Nobuko,HARADA Yosuke,MORINAGA Yoshitomo,IZUMIKAWA Koichi,KAKEYA Hiroshi,HASEGAWA Hiroo,KOHNO Shigeru,KAMIHIRA Shimeru
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 18(4), 472-478, 2012-08-01
NAID 10030947922

山崎繁通,石倉宏恭,紙谷孝則,田中潤一,西澤新也,高良真一,東原秀行,岩下英之,坂暁子,吉兼誠,向坂彰太郎
日本腹部救急医学会雑誌 = Journal of abdominal emergency medicine 31(5), 705-712, 2011-07-31
NAID 10029879944

Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases : a multi-institutional study

NAKAGAWA Yasunori,SUZUKI Kenshi,HIROSE Takayuki,CHOU Takaaki,FUJISAWA Shin,KIDA Michiko,USUKI Kensuke,ISHIDA Yoji,TANIGUCHI Shuichi,KOUZAI Yasuji,TOMOYASU Shigeru,MIYAZAKI Koji,HIGASHIHARA Masaaki,ANDO Kiyoshi,AOKI Sadao,ARAI Ayako,AKIYAMA Nobu,HATAKE Kiyohiko,OKAMOTO Shinichiro,DAN Kazuo,OHYASHIKI Kazuma,URABE Akio
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 17(1), 58-67, 2011-02-01
NAID 10027816744

Biapenem
Systematic (IUPAC) name
	(4R,5S,6S)-3-(6,7-dihydro-5H- pyrazolo[1,2-a][1,2,4]triazol-8- ium-6-ylsulfanyl)- 6-(1-hydroxyethyl)- 4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2- ene-2-carboxylate
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only;
Routes	IV
Identifiers
CAS number	120410-24-4
ATC code	J01DH05
PubChem	CID 71339
ChemSpider	64442
UNII	YR5U3L9ZH1
ChEBI	CHEBI:3089
ChEMBL	CHEMBL285347
Chemical data
Formula	C15H18N4O4S
Mol. mass	350.39 g/mol
	SMILES CC1C2C(C(=O)N2C(=C1SC3CN4C=NC=[N+]4C3)C(=O)[O-])C(C)O;
	InChI InChI=1S/C15H18N4O4S/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)24-9-3-17-5-16-6-18(17)4-9/h5-11,20H,3-4H2,1-2H3/t7-,8-,10-,11-/m1/s1 ; Key:MRMBZHPJVKCOMA-YJFSRANCSA-N ;
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