English Journal

Sikka G1, Hussmann GP2, Pandey D1, Cao S1, Hori D3, Park JT1, Steppan J1, Kim JH1, Barodka V1, Myers AC4, Santhanam L5, Nyhan D1, Halushka MK6, Koehler RC1, Snyder SH7, Shimoda LA8, Berkowitz DE9.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 Dec 16;111(50):17977-82. doi: 10.1073/pnas.1420258111. Epub 2014 Nov 17.
Melanopsin (opsin4; Opn4), a non-image-forming opsin, has been linked to a number of behavioral responses to light, including circadian photo-entrainment, light suppression of activity in nocturnal animals, and alertness in diurnal animals. We report a physiological role for Opn4 in regulating blood
PMID 25404319

Angiotensin II stimulates fibronectin protein synthesis via a Gβγ/arachidonic acid-dependent pathway.

Alexander LD1, Ding Y2, Alagarsamy S2, Cui X2.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2014 Aug 1;307(3):F287-302. doi: 10.1152/ajprenal.00094.2014. Epub 2014 Jun 11.
In rabbit proximal tubular cells, ANG II type 2-receptor (AT2)-induced arachidonic acid release is PLA2 coupled and dependent of G protein βγ (Gβγ) subunits. Moreover, ANG II activates ERK1/2 and transactivates EGFR via a c-Src-dependent mechanism. Arachidonic acid has been shown to mimic this e
PMID 24920755

Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages.

Sorriento D1, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn GW 2nd, Trimarco B, Iaccarino G.
FEBS letters.FEBS Lett.2013 Nov 1;587(21):3487-94. doi: 10.1016/j.febslet.2013.09.002. Epub 2013 Sep 10.
G-protein-coupled receptor kinase 2 (GRK2) levels are elevated in inflammation but its role is not clear yet. Here we show that GRK2 expression is dependent on NFκB transcriptional activity. In macrophages, LPS induces GRK2 accumulation in mitochondria increasing biogenesis. The overexpression of t
PMID 24036448