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関: benzydamine

WordNet

a complex consisting of an organic base in association with hydrogen chloride

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/28 15:38:06」(JST)

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Benzydamine (also known as Tantum Verde and branded in some countries as Difflam), available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat.^[1]

Medical use

Odontostomatology: gingivitis, stomatitis, glossitis, aphthous ulcers, dental surgery and oral ulceration due to radiation therapy.

Otorhinolaryngology: pharyngitis, tonsillitis, post-tonsillectomy, radiation or intubation mucositis.

It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction.

In some markets, the drug is supplied as an over-the-counter cream (Lonol in Mexico from Boehringer Ingelheim) used for topical treatment of musculoskeletal system disorders: sprains, strains, bursitis, tendinitis, synovitis, myalgia, periarthritis.

Antimicrobial activity

Studies indicate that benzydamine has notable in vitro antibacterial activity and also shows synergism in combination with other antibiotics, especially tetracyclines, against antibiotic-resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa. ^[2]^[3]

Contraindications

1.pregnancy 2.lactation 3.Hypersensitivity

Side effects

Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur.

Pharmacology

It selectively binds to inflamed tissues (Prostaglandin synthetase inhibitor) and is normally free of adverse systemic effects. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic.^[4]

Recreational use

Benzydamine has been used recreationally. In overdosages it acts a deliriant and CNS stimulant.^[4] Such use, particularly among teenagers, has been reported in Poland,^[4] Brazil^[5]^[6] and Romania.

References

^ Turnbull, R. S. (1995). "Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions". Journal (Canadian Dental Association) 61 (2): 127–134. PMID 7600413. edit
^ Fanaki NH, el-Nakeeb MA. Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent. J Chemother. 1992 Dec;4(6):347-52. PMID 1287137
^ Fanaki NH, el-Nakeeb MA. Antibacterial activity of benzydamine and antibiotic-benzydamine combinations against multifold resistant clinical isolates. Arzneimittelforschung. 1996 Mar;46(3):320-3. PMID 8901158
^ ^a ^b ^c Anand, J. S.; Lukasik–Glębocka, M.; Korolkiewicz, R. P. (2007). "Letter to the Editor: Recreational abuse with benzydamine hydrochloride (tantum rosa)". Clinical Toxicology 45 (2): 198–199. doi:10.1080/15563650600981210. PMID 17364645. edit
^ Opaleye, E. S.; Noto, A. R.; Sanchez, Z. M.; Moura, Y. G.; Galduróz, J. C.; Carlini, E. A. (2009). "Recreational use of benzydamine as a hallucinogen among street youth in Brazil". Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 31 (3): 208–213. doi:10.1590/S1516-44462009000300005. PMID 19784487. edit
^ Mota, D. M.; Costa, A. A.; Teixeira, C. D. S.; Bastos, A. A.; Dias, M. F. (2010). "Use abusive of benzydamine in Brazil: An overview in pharmacovigilance". Ciencia & saude coletiva (in portuguese) 15 (3): 717–724. doi:10.1590/S1413-81232010000300014. PMID 20464184. edit

External links

"Benzydamine oral rinse". Medicinenet.
"Difflam spray (benzydamine)". Net Doctor, UK.

UpToDate Contents

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1. 小児および思春期における咽頭痛の症状緩和 symptomatic relief of sore throat in children and adolescents
2. 成人における急性咽頭炎の対症療法 symptomatic treatment of acute pharyngitis in adults
3. 頭頸部癌の初期治療中の合併症のマネージメントおよび予防 management and prevention of complications of head and neck cancer during initial treatment
4. 婦人科悪性腫瘍に対する放射線療法の概要 overview of radiation therapy for gynecologic malignancies
5. 成人におけるコカイン関連疾患の治療 treatment of cocaine use disorder in adults

English Journal

Antiseptics and disinfectants for the treatment of bacterial vaginosis: a systematic review.

Verstraelen H, Verhelst R, Roelens K, Temmerman M.AbstractABSTRACT:
BMC infectious diseases.BMC Infect Dis.2012 Jun 28;12(1):148. [Epub ahead of print]
ABSTRACT:BACKGROUND: To assess and summarize the available data on efficacy and tolerability of antiseptics and disinfectants in treating bacterial vaginosis (BV), a systematic search was conducted by consulting the PubMed (1966-2010), CINAHL (1982-2010), IPA (1970-2010), and the Cochrane CENTRAL da
PMID 22742642

In vitro drug metabolism by C-terminally truncated human flavin-containing monooxygenase 3.

Catucci G, Gilardi G, Jeuken L, Sadeghi SJ.SourceDepartment of Life Sciences and Systems Biology, University of Torino, Italy.
Biochemical pharmacology.Biochem Pharmacol.2012 Feb 15;83(4):551-8. Epub 2011 Dec 8.
Human flavin-containing monooxygenase 3 (hFMO3) is a microsomal drug-metabolizing monooxygenase that catalyzes the NADPH-dependent oxygenation of a wide range of drugs and xenobiotics which contain a soft-nucleophiles, usually sulfur or nitrogen. As the release from the microsomal membranes can faci
PMID 22177984

Japanese Journal

Determination of Benzydamine Hydrochloride in Serum and Urine by Using a Benzydamine Ion-Selective Piezoelectric Sensor

LI Weifeng,SU Xiaoli,ZHANG Hong,NIE Lihua,YAO Shuozhuo
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 14(5), 955-960, 1998-10-10
NAID 10002417355

非ステロイド系抗炎症薬の消化管吸収モデルの人工膜への透過性

菅原和信,板垣末広,丹野慶紀
病院薬学 8(4), 237-241, 1982-10-20
… The permeabilities of naproxen, indomethacin, flufenamic acid and aminopyrine except benzydamine hydrochloride through an artificial intestinal membrane were higher than those through an artificial gastric membrane. … The permeabilities through an intestinal membrane of these drugs decreased in the order of flufenamic acid>naproxen>indomethacin>aminopyine>benzydamine hydrochloride. …
NAID 110001796939

「ベンジダミン」

Benzydamine
Systematic (IUPAC) name
	3-(1-benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	B2 (AU)
Legal status	OTC(UK)
Routes	Oral, topical
Pharmacokinetic data
Protein binding	<20%
Half-life	13 hours
Excretion	Renal
Identifiers
CAS number	642-72-8
ATC code	A01AD02 G02CC03 M01AX07 M02AA05
PubChem	CID 12555
ChemSpider	12036
UNII	4O21U048EF
KEGG	D07516
ChEMBL	CHEMBL12610
Chemical data
Formula	C19H23N3O
Mol. mass	309.405 g/mol
	SMILES n2c(OCCCN(C)C)c1ccccc1n2Cc3ccccc3;
	InChI InChI=1S/C19H23N3O/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3 ; Key:CNBGNNVCVSKAQZ-UHFFFAOYSA-N ;
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　　[★]

英: benzydamine、benzydamine hydrochloride
関: 塩酸ベンジダミン

「塩酸ベンジダミン」

　　[★]

英: benzydamine hydrochloride
関: ベンジダミン

「benzydamine」

　　[★]

ベンジダミン

関: benzydamine hydrochloride

「hydrochloride」

　　[★] 塩酸塩、ハイドロクロライド　

[1] Turnbull, R. S. (1995). "Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions". Journal (Canadian Dental Association) 61 (2): 127–134. PMID 7600413. edit

[2] Fanaki NH, el-Nakeeb MA. Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent. J Chemother. 1992 Dec;4(6):347-52. PMID 1287137

[3] Fanaki NH, el-Nakeeb MA. Antibacterial activity of benzydamine and antibiotic-benzydamine combinations against multifold resistant clinical isolates. Arzneimittelforschung. 1996 Mar;46(3):320-3. PMID 8901158

[clintox-4] Anand, J. S.; Lukasik–Glębocka, M.; Korolkiewicz, R. P. (2007). "Letter to the Editor: Recreational abuse with benzydamine hydrochloride (tantum rosa)". Clinical Toxicology 45 (2): 198–199. doi:10.1080/15563650600981210. PMID 17364645. edit

[5] Opaleye, E. S.; Noto, A. R.; Sanchez, Z. M.; Moura, Y. G.; Galduróz, J. C.; Carlini, E. A. (2009). "Recreational use of benzydamine as a hallucinogen among street youth in Brazil". Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 31 (3): 208–213. doi:10.1590/S1516-44462009000300005. PMID 19784487. edit

[6] Mota, D. M.; Costa, A. A.; Teixeira, C. D. S.; Bastos, A. A.; Dias, M. F. (2010). "Use abusive of benzydamine in Brazil: An overview in pharmacovigilance". Ciencia & saude coletiva (in portuguese) 15 (3): 717–724. doi:10.1590/S1413-81232010000300014. PMID 20464184. edit

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関連記事	「benzydamine」「hydrochloride」

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benzydamine hydrochloride