Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/16 23:12:29」(JST)

English Journal

Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory site in rats.

Hori Y, Odaguchi K, Jyoyama H, Yasui K, Mizui T.SourceDivision of Pharmacology, Discovery Research Laboratories II, Shionogi & Co., Ltd., Osaka, Japan.
Japanese journal of pharmacology.Jpn J Pharmacol.1996 Oct;72(2):183-90.
We compared the effects of an anti-ulcer agent, benexate hydrochloride betadex (BHB), on prostaglandin (PG) levels in gastric tissue and inflammatory exudate in untreated and indomethacin-treated rats. BHB (100, 300 and 1000 mg/kg, p.o.) showed dose-dependent inhibition of gastric mucosal lesions in
PMID 8912919

In-vitro and in-vivo antibacterial activity of plaunotol, a cytoprotective antiulcer agent, against Helicobacter pylori.

Koga T, Kawada H, Utsui Y, Domon H, Ishii C, Yasuda H.SourceBiological Research Laboratories, Sankyo Co., Ltd, Tokyo, Japan.
The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.1996 May;37(5):919-29.
Recently, some antiulcer agents have been reported to have antibacterial activity against Helicobacter pylori, which is highly associated with gastritis and peptic ulcers. In-vitro and in-vivo activity of plaunotol, a cytoprotective antiulcer agent, against H. pylori was investigated. Antibacterial
PMID 8737142

宇佐美英治,瀬山義幸,渡辺聡,福井哲也
Japanese Journal of Clinical Chemistry 25(4), 229-234, 1996
… We investigated the lipid radical-scavenging effect of antiulceratives such as Teprenone, Praunotol, Gefarnate, Sofalcone, Rebamipide and Benexate Hydrochloride Betadex using AMVN-induced peroxidation of linoleic acid. … Teprenone did not affect the oxygen uptake rate (R) in the lipid peroxidation but prolonged the initiation time of the oxygen uptake (Tinh), Praunotol and Gefarnate reduced R but did not prolong T inh, Sofalcone, Rebamipide and Benexate Hydrochloride Betadex did not affect either R or T inh. …
NAID 130003357524

リンク元	「ベネキサート」
拡張検索	「benexate hydrochloride betadex」

Benexate
Systematic (IUPAC) name
	phenylmethyl 2-[4-[(diaminomethylideneamino)methyl]cyclohexanecarbonyl]oxybenzoate
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Identifiers
CAS Registry Number	78718-52-2
ATC code	None
PubChem	CID: 2316
ChemSpider	2226
UNII	O3PR2X907M
ChEMBL	CHEMBL2104696
Chemical data
Formula	C23H27N3O4
Molecular mass	409.47 g/mol
	SMILES O=C(OCc1ccccc1)c3ccccc3OC(=O)C2CCC(C/N=C(\N)N)CC2 ;
	InChI InChI=1S/C23H27N3O4/c24-23(25)26-14-16-10-12-18(13-11-16)21(27)30-20-9-5-4-8-19(20)22(28)29-15-17-6-2-1-3-7-17/h1-9,16,18H,10-15H2,(H4,24,25,26) ; Key:IAXUQWSLRKIRFR-UHFFFAOYSA-N ;
(what is this?) (verify)