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Chemical interrogation of drug/RNA complexes: from chemical reactivity to drug design.

Jiménez-Moreno E1, Gómez-Pinto I, Corzana F, Santana AG, Revuelta J, Bastida A, Jiménez-Barbero J, González C, Asensio JL.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2013 Mar 11;52(11):3148-51. doi: 10.1002/anie.201209434. Epub 2013 Feb 7.
PMID 23401341

Influence of charge and structure on the coordination chemistry of copper aminoglycosides.

Patwardhan A1, Cowan JA.
Dalton transactions (Cambridge, England : 2003).Dalton Trans.2011 Feb 28;40(8):1795-801. doi: 10.1039/c0dt00704h. Epub 2011 Jan 10.
Aminoglycosides are a family of molecules based on a 2-deoxystreptamine ring that is functionalized with a variety of sugar units that contain vicinal amine and hydroxyl functionality. These positively-charged amines promote selective high affinity binding to bacterial 16 s rRNA with resultant antib
PMID 21218243

Construction of kanamycin B overproducing strain by genetic engineering of Streptomyces tenebrarius.

Ni X1, Li D, Yang L, Huang T, Li H, Xia H.
Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2011 Feb;89(3):723-31. doi: 10.1007/s00253-010-2908-5. Epub 2010 Oct 9.
Genetic engineering as an important approach to strain optimization has received wide recognition. Recent advances in the studies on the biosynthetic pathways and gene clusters of Streptomyces make stain optimization by genetic alteration possible. Kanamycin B is a key intermediate in the manufactur
PMID 20936279