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English Journal

Red blood cells alloimmunization and autoimmunization among transfusion-dependent beta-thalassemia patients in Alexandria province, Egypt.

Obaid JM1, Abo El-Nazar SY2, Ghanem AM3, El-Hadidi AS4, Mersal BH2.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.Transfus Apher Sci.2015 Aug;53(1):52-7. doi: 10.1016/j.transci.2015.03.006. Epub 2015 Mar 12.
BACKGROUND: Beta thalassemia is considered a severe, progressive anemia, which needs regular transfusions for life expectancy. One of the most important complications of regular blood transfusions is autoimmunization and alloimmunization, which increases the need for transfusion. This study was perf
PMID 25817267

Intrathymic Tfh/B Cells Interaction Leads to Ectopic GCs Formation and Anti-AChR Antibody Production: Central Role in Triggering MG Occurrence.

Zhang X1,2,3, Liu S1,2, Chang T1, Xu J1, Zhang C2, Tian F4, Sun Y2, Song C2, Yi W5, Lin H1, Li Z6, Yang K7.
Molecular neurobiology.Mol Neurobiol.2014 Nov 19. [Epub ahead of print]
Myasthenia gravis is a typical acetylcholine receptor (AChR) antibody-mediated autoimmune disease in which thymus frequently presents follicular hyperplasia or thymoma. It is now widely accepted that the thymus is probably the site of AChR autosensitization and autoantibody production. However, the
PMID 25407929

Innate immunity in myasthenia gravis thymus: pathogenic effects of Toll-like receptor 4 signaling on autoimmunity.

Cordiglieri C1, Marolda R2, Franzi S3, Cappelletti C4, Giardina C5, Motta T6, Baggi F7, Bernasconi P8, Mantegazza R9, Cavalcante P10.
Journal of autoimmunity.J Autoimmun.2014 Aug;52:74-89. doi: 10.1016/j.jaut.2013.12.013. Epub 2014 Jan 4.
The thymus is the main site of immune sensitization to AChR in myasthenia gravis (MG). In our previous studies we demonstrated that Toll-like receptor (TLR) 4 is over-expressed in MG thymuses, suggesting its involvement in altering the thymic microenvironment and favoring autosensitization and autoi
PMID 24397961