- 同
- ATM
WordNet
- undergo mutation; "cells mutate"
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- inability to coordinate voluntary muscle movements; unsteady movements and staggering gait (同)ataxy, dyssynergia, motor_ataxia
PrepTutorEJDIC
- 変化する / 変種を生じる / 〈言語が〉雑音変異する / …‘を'変化させる
- 蛋白(たんばく)質
UpToDate Contents
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English Journal
- Productive Replication of Human Papillomavirus 31 Requires DNA Repair Factor Nbs1.
- Anacker DC1, Gautam D1, Gillespie KA1, Chappell WH1, Moody CA2.
- Journal of virology.J Virol.2014 Aug 1;88(15):8528-8544. Epub 2014 May 21.
- Activation of the ATM (ataxia telangiectasia-mutated kinase)-dependent DNA damage response (DDR) is necessary for productive replication of human papillomavirus 31 (HPV31). We previously found that DNA repair and homologous recombination (HR) factors localize to sites of HPV replication, suggesting
- PMID 24850735
- Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019.
- Vecchio D1, Daga A, Carra E, Marubbi D, Baio G, Neumaier CE, Vagge S, Corvò R, Pia Brisigotti M, Louis Ravetti J, Zunino A, Poggi A, Mascelli S, Raso A, Frosina G.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Jul 15;135(2):479-91. doi: 10.1002/ijc.28680. Epub 2014 Jan 8.
- We have previously shown that pharmacological inhibition of ataxia telangiectasia mutated (ATM) protein sensitizes glioblastoma-initiating cells (GICs) to ionizing radiation (IR). Herein, we report the experimental conditions to overcome GIC radioresistance in vitro using the specific ATM inhibitor
- PMID 24443327
- High resistance to X-rays and therapeutic carbon ions in glioblastoma cells bearing dysfunctional ATM associates with intrinsic chromosomal instability.
- Dokic I, Mairani A, Brons S, Schoell B, Jauch A, Krunic D, Debus J, Régnier-Vigouroux A, Weber KJ.
- International journal of radiation biology.Int J Radiat Biol.2014 Jul 3:1-22. [Epub ahead of print]
- Abstract Purpose: To investigate chromosomal instability and radiation response mechanisms in glioblastoma cells. Methods and Materials: We undertook a comparative analysis of two patient-derived glioblastoma cell lines. Their resistance to low and high linear energy transfer (LET) radiation was ass
- PMID 24991884
Japanese Journal
- A Novel ATM/TP53/p21-Mediated Checkpoint Only Activated by Chronic γ-Irradiation
- Cao Lili,Kawai Hidehiko,Sasatani Megumi,Iizuka Daisuke,Masuda Yuji,Inaba Toshiya,Suzuki Keiji,Ootsuyama Akira,Umata Toshiyuki,Kamiya Kenji,Suzuki Fumio
- PLoS ONE 9(8), e104279, 2014-08-05
- … We demonstrate a critical role for the ataxia telangiectasia mutated (ATM)/tumor protein p53 (TP53)/p21 pathway in regulating DNA-damage-associated cell fate. …
- NAID 120005477031
- Glionitrin A, a New Diketopiperazine Disulfide, Activates ATM-ATR-Chk1/2 via 53BP1 Phosphorylation in DU145 Cells and Shows Antitumor Effect in Xenograft Model
- Kim Young-Joo,Park Hyun Bong,Yoo Ji-Hye,Kwon Hak Cheol,Kim Joonki,Yang Hyun Ok
- Biological and Pharmaceutical Bulletin 37(3), 378-386, 2014
- … Glionitrin A-treated cells exhibited elevated levels of phospho-histone 2AX (Ser139), a marker of DNA damage, and accumulated in both S phase and G2/M phase due to the activation of checkpoints associated with the ataxia-telangiectasia-mutated and ataxia-telangiectasia-mutated-Rad3-related Chk1/2 pathway downstream of p53-binding protein 1 phosphorylation at Ser1778. …
- NAID 130003390943
- Role of NBS1 in DNA damage response and its relationship with cancer development
- Saito Yuichiro,Fujimoto Hiroko,Kobayashi Junya
- Translational Cancer Research 2(3), 178-189, 2013-06
- … Nijmegen breakage syndrome (NBS) is a recessive genetic disorder characterized by an elevated sensitivity to ionizing radiation, chromosome instability, and a high frequency of malignancies phenotypes similar to those of ataxia-telangiectasia (A-T). … NBS1, the product of the causative gene in NBS, contains several protein-interaction motifs in the N-terminus and C-terminus. …
- NAID 120005300469
Related Links
- 1. J Biol Chem. 2013 May 31;288(22):16139-44. doi: 10.1074/jbc.M113.456780. Epub 2013 Apr 16. Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A ...
- The ATM gene provides instructions for making a protein that is located primarily in the nucleus of cells, where it helps control the rate at which cells grow and divide. This protein also plays an important role in the normal ...
★リンクテーブル★
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- 関
- discontinuous variation、mutant、mutation、transmutation、variant、variation、variational
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毛細血管拡張性運動失調症