PrepTutorEJDIC

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 先天性子宮奇形の臨床症状および診断 clinical manifestations and diagnosis of congenital anomalies of the uterus
2. グレリン ghrelin
3. レプチンの生理学 physiology of leptin
4. 多系統萎縮症：臨床的特徴および診断 multiple system atrophy clinical features and diagnosis
5. ペルオキシソーム病 peroxisomal disorders

Differential expression of CART in feeding and reward circuits in binge eating rat model.

Bharne AP1, Borkar CD1, Subhedar NK2, Kokare DM3.
Behavioural brain research.Behav Brain Res.2015 Sep 15;291:219-31. doi: 10.1016/j.bbr.2015.05.030. Epub 2015 May 22.
Binge eating (BE) disrupts feeding and subverts reward mechanism. Since cocaine- and amphetamine-regulated transcript peptide (CART) mediates satiety as well as reward, its role in BE justifies investigation. To induce BE, rats were provided restricted access to high fat sweet palatable diet (HFSPD)
PMID 26008155

Wilson JL1, Enriori PJ2.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Aug 24. pii: S0303-7207(15)30062-9. doi: 10.1016/j.mce.2015.08.022. [Epub ahead of print]
The incidence of obesity and its related disorders are increasing at a rate of pandemic proportions. Understanding the mechanisms behind the maintenance of energy balance is fundamental in developing treatments for clinical syndromes including obesity and diabetes. A neural network located in the nu
PMID 26316427

Leptin receptor expressing neurons express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activation in PDE3B neurons in the mouse hypothalamus.

Sahu M1, Sahu A2.
Peptides.Peptides.2015 Aug 20;73:35-42. doi: 10.1016/j.peptides.2015.08.011. [Epub ahead of print]
Leptin signaling in the hypothalamus is critical for normal food intake and body weight regulation. Cumulative evidence suggests that besides the signal transducer and activator of transcription-3 (STAT3) pathway, several non-STAT3 pathways including the phosphodiesterase-3B (PDE3B) pathway mediate
PMID 26297880

Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus.

Segi-Nishida Eri,Sukeno Mamiko,Imoto Yuki,Kira Toshihiko,Sakaida Mari,Tsuchiya Soken,Sugimoto Yukihiko,Okuno Yasushi
Neuropharmacology 71, 164-173, 2013-08
… Furthermore, gold-thioglucose-induced hypothalamic lesions, including the VMH and the arcuate nucleus, abolished the anorexigenic effects of ECS, indicating the requirement for the activation of the hypothalamus. …
NAID 120005295921