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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/26 15:20:03」(JST)

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Aquaporin 1 is a protein that in humans is encoded by the AQP1 gene.

AQP1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle, and in the descending portion of the vasa recta. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, and lungs.

It is not regulated by vasopressin (ADH).

Function

Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement.^[1]

References

^ "Entrez Gene: AQP1 aquaporin 1 (Colton blood group)".

External links

Aquaporin 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
Gallery of Aquaporin Simulations

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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1. Chapter 5B：集合管 chapter 5b collecting tubules
2. 羊水過少 oligohydramnios
3. 急性腎障害（急性腎不全）の治療のための腹膜透析の使用 use of peritoneal dialysis for the treatment of acute kidney injury acute renal failure
4. 羊水量調節の生理学 physiology of amniotic fluid volume regulation
5. 赤血球水分量の制御 control of red blood cell hydration

English Journal

A generic high-throughput assay to detect aquaporin functional mutants: Potential application to discovery of aquaporin inhibitors.

To J1, Yeo CY1, Soon CH1, Torres J2.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Sep;1850(9):1869-76. doi: 10.1016/j.bbagen.2015.05.019. Epub 2015 May 29.
BACKGROUND: The discovery of stable, yet functional, protein mutants is a limiting factor in the development of biotechnological applications, structural studies or in drug discovery. Rapid detection of functional mutants is especially challenging for water channel aquaporins, as they do not have a
PMID 26028295

Water and solute transport across the peritoneal membrane.

Morelle J1, Devuyst O.
Current opinion in nephrology and hypertension.Curr Opin Nephrol Hypertens.2015 Sep;24(5):434-43. doi: 10.1097/MNH.0000000000000151.
PURPOSE OF REVIEW: We review the molecular mechanisms of peritoneal transport and discuss how a better understanding of these mechanisms is relevant for dialysis therapy.RECENT FINDINGS: Peritoneal dialysis involves diffusion and osmosis through the highly vascularized peritoneal membrane. Computer
PMID 26197201

PBEF promotes the apoptosis of pulmonary microvascular endothelial cells and regulates the expression of inflammatory factors and AQP1 through the MAPK pathways.

Ming GF1, Ma XH1, Xu DM1, Liu ZY1, Ai YH1, Liu HX2, Shi ZH3.
International journal of molecular medicine.Int J Mol Med.2015 Sep;36(3):890-6. doi: 10.3892/ijmm.2015.2283. Epub 2015 Jul 13.
Pre-B cell colony-enhancing factor (PBEF) has been shown to have a variety of biological functions. Studies have proven that PBEF plays a functional role in acute lung injury (ALI). Therefore, in this study, we aimed to confirm the importance of PBEF in ALI. The effects of PBEF overexpression on t
PMID 26178576

Japanese Journal

抗MOG抗体が強陽性であったChronic relapsing inflammatory optic neuropathy（CRION）の1例

神経眼科 33(1), 27-31, 2016
NAID 130005143508

Intractable Hiccups and Nausea as a Principal Symptom of Neuromyelitis Optica in a Patient with a Prior History of Miller-Fisher Syndrome

Journal of General and Family Medicine 17(1), 99-104, 2016
NAID 130005140297

フィンゴリモド投与中に帯状疱疹を発症した多発性硬化症の検討

臨床神経学 advpub(0), 2016
NAID 130005139515

「アクアポリン1」

Aquaporin 1 (Colton blood group)
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1FQY, 1H6I, 1IH5
Identifiers
Symbols	AQP1 ; AQP-CHIP; CHIP28; CO
External IDs	OMIM: 107776 MGI: 103201 HomoloGene: 68051 IUPHAR: 688 GeneCards: AQP1 Gene
Gene ontology
Molecular function	• intracellular cGMP activated cation channel activity; • potassium channel activity; • water transmembrane transporter activity; • protein binding; • ammonium transmembrane transporter activity; • potassium ion transmembrane transporter activity; • glycerol transmembrane transporter activity; • water channel activity; • transmembrane transporter activity; • nitric oxide transmembrane transporter activity; • carbon dioxide transmembrane transporter activity;
Cellular component	• nucleus; • cytoplasm; • plasma membrane; • integral component of plasma membrane; • brush border; • basal plasma membrane; • basolateral plasma membrane; • apical plasma membrane; • symbiont-containing vacuole; • symbiont-containing vacuole membrane; • brush border membrane; • nuclear membrane; • sarcolemma; • apical part of cell; • extracellular vesicular exosome;
Biological process	• renal water transport; • cGMP biosynthetic process; • potassium ion transport; • water transport; • cell volume homeostasis; • carbon dioxide transport; • ammonium transport; • bicarbonate transport; • glycerol transport; • cellular homeostasis; • lateral ventricle development; • pancreatic juice secretion; • nitric oxide transport; • establishment or maintenance of actin cytoskeleton polarity; • cerebrospinal fluid secretion; • cellular response to stress; • cellular response to UV; • transepithelial water transport; • carbon dioxide transmembrane transport; • odontogenesis; • response to drug; • negative regulation of apoptotic process; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • small molecule metabolic process; • positive regulation of angiogenesis; • positive regulation of saliva secretion; • positive regulation of fibroblast proliferation; • multicellular organismal water homeostasis; • transmembrane transport; • cellular response to hydrogen peroxide; • cellular response to inorganic substance; • cellular response to mechanical stimulus; • cellular response to copper ion; • cellular response to mercury ion; • cellular response to retinoic acid; • cellular response to cAMP; • cellular response to hypoxia; • cellular response to salt stress; • cellular hyperosmotic response; • cellular response to dexamethasone stimulus; • cellular response to nitric oxide; • potassium ion transmembrane transport; • ammonium transmembrane transport; • maintenance of symbiont-containing vacuole by host;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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