Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/11 16:12:07」(JST)

wiki en

Aquaporin 1 is a protein that in humans is encoded by the AQP1 gene.

AQP1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle, and in the descending portion of the vasa recta. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, and lungs.

It is not regulated by vasopressin (ADH).

Function

Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement.^[1]

References

^ "Entrez Gene: AQP1 aquaporin 1 (Colton blood group)".

External links

Aquaporin 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
Gallery of Aquaporin Simulations

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

English Journal

Potential roles of aquaporin 9 in the pathogenesis of endometriosis.

Choi YS, Park JH, Yoon JK, Yoon JS, Kim JS, Lee JH, Yun BH, Park JH, Seo SK, Cho S, Lee BS, Taylor HS.
Molecular human reproduction. 2019 May;().
Aquaporins (AQPs) are involved in cell migration, proliferation, and carcinogenesis in tumor development and physiologic inflammatory processes, but their associations with endometriosis has not been fully evaluated. In this study, tissue samples were obtained from women undergoing laparoscopic surg
PMID 31070762

Differential Expression and Localization of Branchial AQP1 and AQP3 in Japanese Medaka ().

Ellis LV, Bollinger RJ, Weber HM, Madsen SS, Tipsmark CK.
Cells. 2019 May;8(5).
Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka ( in response to osm
PMID 31072010

Involvement of p38 Mitogen-Activated Protein Kinase in Altered Expressions of AQP1 and AQP4 after Carbon Monoxide Poisoning in Rat Astrocytes.

Li J, Jia M, Chen G, Nie S, Zheng C, Zeng W, Xu Y, Wang C, Cao X, Liu Q.
Basic & clinical pharmacology & toxicology. 2019 May;().
Cerebral oedema is a major pathological change of acute carbon monoxide (CO) poisoning, the pathogenesis of which is still unclear. In the aquaporin (AQP) water channel family, AQP1 and AQP4 play critical roles in the progress of cerebral oedema of various neuropathological events. However, their fu
PMID 31063681

Japanese Journal

Regulation of Macrophage Motility by the Water Channel Aquaporin-1: Crucial Role of M0/M2 Phenotype Switch

PLOS ONE 10(2), e0117398, 2015-02-26
NAID 120005602581

Effect of goreisan on urinary concentrating ability and expression of aquaporin-2 in 5/6 nephrectomized rats

Journal of Traditional Medicines 30(4), 145-157, 2013
NAID 130004942430

The three-dimensional microanatomy of the pancreatic duct system in the Japanese monkey, Macaca fuscata, with special reference to fine proximal passages of a high species-specificity

Biomedical Research 34(1), 51-60, 2013
NAID 130004470834

Related Pictures

AQP1 Antibody 20333-1-AP | Proteintech 抗AQP1抗体 | Anti-AQP1 Antibody | フナコシ Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the Formalin-fixed and paraffin embedded human placenta labeled with Anti-AQP1/CHIP

★リンクテーブル★

リンク元	「アクアポリン1」「aquaporin 1」
関連記事	「AQP」

「アクアポリン1」

Aquaporin 1 (Colton blood group)
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1FQY, 1H6I, 1IH5, 4CSK
Identifiers
Symbols	AQP1 ; AQP-CHIP; CHIP28; CO
External IDs	OMIM: 107776 MGI: 103201 HomoloGene: 68051 IUPHAR: 688 GeneCards: AQP1 Gene
Gene ontology
Molecular function	• intracellular cGMP activated cation channel activity; • potassium channel activity; • water transmembrane transporter activity; • protein binding; • ammonium transmembrane transporter activity; • potassium ion transmembrane transporter activity; • glycerol transmembrane transporter activity; • water channel activity; • glycerol channel activity; • transmembrane transporter activity; • nitric oxide transmembrane transporter activity; • carbon dioxide transmembrane transporter activity; • ephrin receptor binding;
Cellular component	• nucleus; • cytoplasm; • plasma membrane; • integral component of plasma membrane; • brush border; • basal plasma membrane; • basolateral plasma membrane; • apical plasma membrane; • symbiont-containing vacuole; • symbiont-containing vacuole membrane; • brush border membrane; • nuclear membrane; • sarcolemma; • axon terminus; • apical part of cell; • extracellular exosome;
Biological process	• renal water homeostasis; • glomerular filtration; • renal water transport; • cGMP biosynthetic process; • potassium ion transport; • water transport; • cell volume homeostasis; • cellular water homeostasis; • positive regulation of lamellipodium assembly; • positive regulation of epithelial cell migration; • carbon dioxide transport; • ammonium transport; • bicarbonate transport; • glycerol transport; • sensory perception of pain; • cellular homeostasis; • lateral ventricle development; • pancreatic juice secretion; • nitric oxide transport; • establishment or maintenance of actin cytoskeleton polarity; • cerebrospinal fluid secretion; • secretory granule organization; • cellular response to stress; • cellular response to UV; • transepithelial water transport; • carbon dioxide transmembrane transport; • wound healing; • odontogenesis; • response to drug; • hyperosmotic salinity response; • negative regulation of apoptotic process; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • response to estrogen; • lipid digestion; • small molecule metabolic process; • positive regulation of angiogenesis; • positive regulation of saliva secretion; • positive regulation of fibroblast proliferation; • camera-type eye morphogenesis; • multicellular organismal water homeostasis; • corticotropin secretion; • transmembrane transport; • renal water absorption; • cellular response to hydrogen peroxide; • cellular response to inorganic substance; • cellular response to mechanical stimulus; • cellular response to copper ion; • cellular response to mercury ion; • cellular response to retinoic acid; • cellular response to cAMP; • cellular response to hypoxia; • cellular response to salt stress; • cellular hyperosmotic response; • cellular response to dexamethasone stimulus; • cellular response to nitric oxide; • potassium ion transmembrane transport; • metanephric descending thin limb development; • metanephric proximal straight tubule development; • metanephric proximal convoluted tubule segment 2 development; • metanephric glomerulus vasculature development; • ammonium transmembrane transport; • maintenance of symbiont-containing vacuole by host; • cation transmembrane transport;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;