WordNet
- any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 抗原(生物の体内にはいって免疫体を作る物質)
- =sense organ / 受信装置
UpToDate Contents
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- 1. 重度複合型免疫不全（SCID）：特定の欠損 severe combined immunodeficiency scid specific defects
- 2. 適応細胞性免疫応答 the adaptive cellular immune response
- 3. Antigen-presenting cells
- 4. T細胞受容体シグナル伝達 t cell receptor signaling
- 5. 体液性免疫応答 the humoral immune response
English Journal
- Comparing label free electrochemical impedimetric and capacitive biosensing architectures.
- Fernandes FC1, Santos A1, Martins DC1, Góes MS1, Bueno PR2.Author information 1Institute of Chemistry, University Estadual Paulista (UNESP, São Paulo State University), CP 355, CEP 14800-900 Araraquara, São Paulo, Brazil.2Institute of Chemistry, University Estadual Paulista (UNESP, São Paulo State University), CP 355, CEP 14800-900 Araraquara, São Paulo, Brazil. Electronic address: prbueno@iq.unesp.br.AbstractThe transducer faradaic signals of molecularly receptive interfaces associated with specific target binding can be sensitively monitored by electrochemical impedance and/or capacitance spectroscopies. A comparative evaluation of both impedimetric (associated with charge transfer resistance) and capacitive (associated with faradaic density of states) approaches was undertaken using C-reactive protein (CRP) antigen and antibody interaction as biomolecular binding model. Aiming at constructing redox free (impedimetric) and redox tethered receptive (capacitive) interfaces engineered by self-assembly monolayer, CRP sensitivity and limit of detections were comparatively assessed regarding biosensor capabilities. Binding affinity constant between CRP and anti-CRP interfacial receptor sites were additionally evaluated by the Langmuir adsorption model. Both the impedimetric and capacitive approaches reported similar values of experimental analytical parameters albeit the latter was found to have the advantage of requiring no solution redox reporter thus making it highly suitable for use in multiplexing affinity arrays.
- Biosensors & bioelectronics.Biosens Bioelectron.2014 Jul 15;57:96-102. doi: 10.1016/j.bios.2014.01.044. Epub 2014 Jan 31.
- The transducer faradaic signals of molecularly receptive interfaces associated with specific target binding can be sensitively monitored by electrochemical impedance and/or capacitance spectroscopies. A comparative evaluation of both impedimetric (associated with charge transfer resistance) and capa
- PMID 24561523
- Development of SPR biosensor for the detection of human hepatitis B virus using plasma-treated parylene-N film.
- Choi YH1, Lee GY1, Ko H1, Chang YW1, Kang MJ2, Pyun JC3.Author information 1Department of Materials Science and Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, Republic of Korea.2Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.3Department of Materials Science and Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, Republic of Korea. Electronic address: jcpyun@yonsei.ac.kr.AbstractA plasma-treated parylene-N film was presented for the immobilization of proteins through physical adsorption. The changes in surface properties of the parylene-N film after plasma-treatment were analyzed using contact angle microscopy and AFM. To demonstrate the high protein-immobilization efficiency of the plasma-treated parylene-N film, the immobilization efficiencies of differently modified surfaces were compared using model proteins with different surface charges, such as streptavidin (pI=5, negatively charged at pH 7), horseradish peroxidase (pI=6.6, nearly neutral at pH 7), and avidin (pI=10, positively charged at pH 7). The application of the plasma-treated parylene-N film as an SPR biosensor was also tested by immobilizing model proteins. An SPR biosensor based on the plasma-treated parylene-N film was developed for the detection of the human hepatitis virus surface antigen (HBsAg), and the plasma-treated parylene-N film was estimated to improve the sensitivity of SPR biosensor as much as 1000-fold by enhancing immobilization of receptor antibodies.
- Biosensors & bioelectronics.Biosens Bioelectron.2014 Jun 15;56:286-94. doi: 10.1016/j.bios.2014.01.035. Epub 2014 Jan 30.
- A plasma-treated parylene-N film was presented for the immobilization of proteins through physical adsorption. The changes in surface properties of the parylene-N film after plasma-treatment were analyzed using contact angle microscopy and AFM. To demonstrate the high protein-immobilization efficien
- PMID 24518301
- Two functionally distinct myeloid dendritic cell subpopulations are present in bovine blood.
- González-Cano P1, Arsic N1, Popowych YI1, Griebel PJ2.Author information 1Vaccine and Infectious Disease Organization-International Vaccine Center, 120 Veterinary Road, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.2Vaccine and Infectious Disease Organization-International Vaccine Center, 120 Veterinary Road, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada; School of Public Health, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada. Electronic address: philip.griebel@usask.ca.AbstractImmature myeloid (m)DCs circulating in the blood of cattle have been defined as lineage negative (Lin(-))MHCII(+)CD11c(+)CD205(+) cells. Lin(-)MHCII(+)CD11c(+)CD205(+) mDCs (0.2% blood mononuclear cells) isolated from bovine blood were heterogeneous in cell size and CD205 expression. Using highspeed cell sorting, Lin(-)MHCII(+)CD11c(+)CD205(+) DCs were sorted into CD205(Hi) and CD205(Lo) subpopulations which were phenotypically distinct and differed significantly (P<0.01) in TLR gene expression. CD205(Hi) and CD205(Lo) mDCs were more efficient in macropinocytosis than monocytes and expressed no or little detectable non-specific esterase activity. CD205(Lo) mDCs efficiently activated purified allogeneic T cells and the addition of TLR agonists did not significantly alter this antigen presentation capacity. T cell activation by CD205(Lo) mDCs was associated with differential up-regulation of CD40, CD80, CD86 and TGFβ1 gene expression when compared to CD205(Hi) mDCs. In conclusion, two phenotypically and functionally distinct CD11c(+)CD205(+) mDCs were isolated from blood that had an equal capacity to acquire antigen but markedly different capacities to activate T cells.
- Developmental and comparative immunology.Dev Comp Immunol.2014 Jun;44(2):378-88. doi: 10.1016/j.dci.2014.01.014. Epub 2014 Feb 3.
- Immature myeloid (m)DCs circulating in the blood of cattle have been defined as lineage negative (Lin(-))MHCII(+)CD11c(+)CD205(+) cells. Lin(-)MHCII(+)CD11c(+)CD205(+) mDCs (0.2% blood mononuclear cells) isolated from bovine blood were heterogeneous in cell size and CD205 expression. Using highspeed
- PMID 24502939
Japanese Journal
- CAR-T遺伝子治療の現状と今後の展開 (第77回日本血液学会学術集会 教育講演特集号) -- (免疫・細胞・遺伝子治療/輸血)
- 小澤 敬也
- 臨床血液 56(10), 2180-2185, 2015-10
- NAID 40020597370
- High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-positive T cells into tumor sites
- Naito Tatsushi,Baba Tomohisa,Takeda Kazuyoshi,Sasaki Soichiro,Nakamoto Yasunari,Mukaida Naofumi
- Cancer Letters 336(1), 93-96, 2015-09-28
- … CTX treatment induced the rapid recruitment of CD4+ T cells into the tumors, and these recruited cells initiated expression of LAMP1/CD107a, a cytotoxic granule molecule, and granzyme B in the absence of antigen presentation at draining lymph nodes and proliferation in the tumor tissues. … Moreover, CTX enhanced the expression of a CC chemokine, CCL3, in tumor tissues, and CTX-mediated tumor regression was attenuated in mice deficient in CCR5, the receptor for this chemokine. …
- NAID 120005646680
- Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice
- Tobinaga Shuichi,Matsumoto Keitaro,Nagayasu Takeshi,Furukawa Katsuro,Abo Takafumi,Yamasaki Naoya,Tsuchiya Tomoshi,Miyazaki Takuro,Koji Takehiko
- Acta Histochemica et Cytochemica 48(3), 83-94, 2015-06-29
- … In the lung, the expression of proliferating cell nuclear antigen (PCNA) was augmented, and surfactant protein A (SP-A) and KGF receptor (KGFR) were co-expressed in PCNA-positive cells. …
- NAID 120005627352
Related Links
- T-Cell Receptors for Antigen (TCRs) alpha/beta (αβ) T cells The antigen receptor on most T cells is made up of two transmembrane polypeptides designated alpha and beta (thus forming a heterodimer). Like antibodies each has an N ...
- Antigen Receptor Diversity The human genome is presently estimated to contain 20–25 thousand genes. The number of T-cell receptors for antigen (TCRs) that we make is estimated at 2.5 x 10 7; the number of different kinds of ...
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★リンクテーブル★
| リンク元 | 「抗原レセプター」 |
| 拡張検索 | 「T-cell antigen receptor」「very late antigen receptor」「T-cell antigen receptor-CD3 complex」「B-cell antigen receptor」 |