English Journal

Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose.

Knoll K1, Anzengruber F1, Cozzio A1, French LE1, Murer C1, Navarini AA1.
Case reports in dermatology.Case Rep Dermatol.2016 Nov 7;8(3):287-293. eCollection 2016 Sep-Dec.
PMID 27920680

Sublethal effects of trimethoprim on four freshwater organisms.

De Liguoro M1, Di Leva V, Dalla Bona M, Merlanti R, Caporale G, Radaelli G.
Ecotoxicology and environmental safety.Ecotoxicol Environ Saf.2012 Aug;82:114-21. doi: 10.1016/j.ecoenv.2012.05.016. Epub 2012 Jun 9.
PMID 22687886

4-Substituted anilino imidazo[1,2-a] and triazolo[4,3-a]quinoxalines. Synthesis and evaluation of in vitro biological activity.

Corona P1, Vitale G, Loriga M, Paglietti G, La Colla P, Collu G, Sanna G, Loddo R.
European journal of medicinal chemistry.Eur J Med Chem.2006 Sep;41(9):1102-7. Epub 2006 Jul 7.
PMID 16828932

Japanese Journal

抗リウマチ薬により生じた口腔潰瘍の3例

山下雅子,神部芳則,相澤恵美,森良之
日本口腔内科学会雑誌 22(1), 46-50, 2016
メトトレキサート（MTX）は葉酸の構造類似体で，葉酸代謝酵素による活性型葉酸への変換を阻害し，細胞増殖を抑制する葉酸代謝拮抗剤に分類される抗癌剤である。低用量のMTXは疾患修飾性抗リウマチ薬（DMARD）として位置づけられており，関節リウマチ（RA）の治療で使用されている。今回われわれはMTX内服中に口腔粘膜に潰瘍を呈し，いずれも休薬により寛解した3症例を経験したので若干の文献的考察を加えて報告す …
NAID 130006909079

Methotrexate-Loxoprofen Interaction: Involvement of Human Organic Anion Transporters hOAT1 and hOAT3

UWAI Yuichi,TANIGUCHI Risa,MOTOHASHI Hideyuki,SAITO Hideyuki,OKUDA Masahiro,INUI Ken-ichi
薬物動態 19(5), 369-374, 2004
… Human organic anion transporters hOAT1 (SLC22A6) and hOAT3 (SLC22A8) are responsible for renal tubular secretion of an antifolic acid methotrexate, and are considered to be involved in drug interaction of methotrexate with nonsteroidal anti-inflammatory drugs (NSAIDs). …
NAID 130004462944

Bone Marrow Treatment of Mice Lethally Irradiated with Gamma-Rays under High Dose Rate (VI) : Application of Antifolic "Methotrexate" for Suppression of Immune Response (Special Issue on Physical, Chemical and Biological Effects of Gamma Radiation, V)

Adachi Kazushige,Hama Masaharu,Yamagishi Morihisa,Uchino Haruto,Wakisaka Gyouiti
Bulletin of the Institute for Chemical Research, Kyoto University 42(1), 63-67, 1964-02-29
NAID 120001266302

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Antifolic | definition of antifolic by Medical dictionary

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ライフサイエンス辞書: 葉

antifolic (n*) 葉酸代謝拮抗薬 ** ようさんたいしゃきっこうやくシソーラス PubMed, Scholar, Google, WikiPedia 【類義語】抗葉酸性, 葉酸拮抗薬, 葉酸代謝拮抗剤, 葉酸代謝拮抗物質 antifolate *** (n*) コーパス antifolic (n*) 葉酸トランス ...

Antifolic dictionary definition | antifolic defined

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