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English Journal

Evaluation of response to hormone therapy in patients with measurable adult granulosa cell tumors of the ovary.

van Meurs HS1, van der Velden J1, Buist MR1, van Driel WJ2, Kenter GG1, van Lonkhuijzen LR1.
Acta obstetricia et gynecologica Scandinavica.Acta Obstet Gynecol Scand.2015 Nov;94(11):1269-75. doi: 10.1111/aogs.12720. Epub 2015 Sep 15.
INTRODUCTION: The aim of this study was to retrospectively determine the objective response rate to hormone therapy (HT) for patients with a measurable adult granulosa cell tumor (GCT) of the ovary in a consecutive series of patients.MATERIAL AND METHODS: All patients with an adult GCT who were trea
PMID 26230362

Di Lauro L1, Barba M2, Pizzuti L1, Vici P1, Sergi D1, Di Benedetto A3, Mottolese M3, Speirs V4, Santini D5, De Maria R6, Maugeri-Saccà M7.
Cancer letters.Cancer Lett.2015 Nov 1;368(1):20-5. doi: 10.1016/j.canlet.2015.07.040. Epub 2015 Aug 11.
Cancers arising in the male breast are uncommon. Male breast cancer is a hormone-driven disease that often expresses the estrogen receptor, and antiestrogen therapy represents the mainstay of treatment. Paradoxically, the advent of a wave of antiestrogens eclipsed the therapeutic potential of altern
PMID 26276719

Could in-vitro studies on Ishikawa cell lines explain the endometrial safety of raloxifene? Systematic literature review and starting points for future oncological research.

Gizzo S1, Noventa M, Di Gangi S, Litta P, Saccardi C, D'Antona D, Nardelli GB.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).Eur J Cancer Prev.2015 Nov;24(6):497-507. doi: 10.1097/CEJ.0000000000000107.
To evaluate all the in-vitro raloxifene (RAL) mechanisms of action on normal, Ishikawa, and different endometrium-derived cell lines to explain the in-vivo RAL endometrial effects, a systematic literature search was performed in the electronic databases MEDLINE, EMBASE ScienceDirect, and the Cochran
PMID 25536299

山下哲正,紅林淳一,鹿股直樹,下登志朗,森谷卓也,園尾博司
川崎医学会誌 39(3), 65-79, 2013
乳癌を含め多くの固形腫瘍において,癌幹細胞(CSC)が治療抵抗性や再発の原因となることが示唆されている.一方, エストロゲン感受性乳癌におけるCSCの制御機構に関する研究は少ない.そこで,エストロゲン受容体(ER)陽性乳癌細胞におけるエストロゲンや抗エストロゲン薬(抗E薬)の細胞増殖やCSC制御に与える影響について検討した.さらに,内分泌療法抵抗性乳癌に有効性が期待されているmTOR阻害薬エベロリ …
NAID 110009632690