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1. 抗利尿ホルモン不適合分泌（SIADH）症候群の病態生理および病因 pathophysiology and etiology of the syndrome of inappropriate antidiuretic hormone secretion siadh
2. 分娩第3期のマネージメントのための薬物療法 pharmacologic management of the third stage of labor
3. 羊水過少 oligohydramnios
4. クッシング病の一次治療：経蝶形骨洞手術および下垂体照射 primary therapy of cushings disease transsphenoidal surgery and pituitary irradiation
5. 常染色体優性多発性嚢胞腎の経過および治療 course and treatment of autosomal dominant polycystic kidney disease

de Groot T1, Sinke AP1, Kortenoeven ML1, Alsady M1, Baumgarten R2, Devuyst O3, Loffing J4, Wetzels JF5, Deen PM6.
Journal of the American Society of Nephrology : JASN.J Am Soc Nephrol.2015 Nov 16. pii: ASN.2015070796. [Epub ahead of print]
To reduce lithium-induced nephrogenic diabetes insipidus (lithium-NDI), patients with bipolar disorder are treated with thiazide and amiloride, which are thought to induce antidiuresis by a compensatory increase in prourine uptake in proximal tubules. However, thiazides induced antidiuresis and alka
PMID 26574046

Mutation in the V2 vasopressin receptor gene, AVPR2, causes nephrogenic syndrome of inappropriate diuresis.

Erdélyi LS1,2, Mann WA3, Morris-Rosendahl DJ4, Groß U5, Nagel M6, Várnai P1,2, Balla A1,2, Hunyady L1,2.
Kidney international.Kidney Int.2015 Nov;88(5):1070-8. doi: 10.1038/ki.2015.181. Epub 2015 Jul 1.
Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a recently discovered rare disease caused by gain-of-function mutations of the V2 vasopressin receptor gene, AVPR2. To date, mutations of Phe229 and Arg137 have been identified as gain-of-function in the V2 vasopressin receptor (V2R). The
PMID 26131744

Cyclophosphamide-induced vasopressin-independent activation of aquaporin-2 in the rat kidney.

Kim S1, Choi HJ2, Jo CH1, Park JS3, Kwon TH2, Kim GH4.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2015 Sep 1;309(5):F474-83. doi: 10.1152/ajprenal.00477.2014. Epub 2015 Jun 24.
Because cyclophosphamide-induced hyponatremia was reported to occur without changes in plasma vasopressin in a patient with central diabetes insipidus, we hypothesized that cyclophosphamide or its active metabolite, 4-hydroperoxycyclophosphamide (4-HC), may directly dysregulate the expression of wat
PMID 26109089

A Special Focus on the Role of .ALPHA.1D-Adrenoreceptors in the Assessment of Renal Tubular Sodium Re-absorptive Responses in Spontaneously Hypertensive Rats Subjected to High Sodium Diet

Kazi Raisa N.,Sattar Munavvar A.,Abdullah Nor A. [他],KHAN Md A. Hye,RATHORE Hassaan A.,ABDULLA Mohammed H.,SALMAN Ibrahim M.,JOHNS Edward J.
YAKUGAKU ZASSHI 131(3), 431-436, 2011
… Further, high sodium intake did not significantly influence the functionality of α1D-adrenoceptors in mediating the adrenergically induced antinatriuresis and antidiuresis. …
NAID 130000678908

海外論文紹介 : Nephrogenic Syndrome of Inappropriate Antidiuresis in Adults: High phenotypic variability in Men and Women from a Large Pedigree

粟津緑
Nihon Shoni Jinzobyo Gakkai Zasshi 21(1), 72-73, 2008
… 　Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) は遺伝性の低Na血症を来す疾患で, 男性乳児例が報告されている。 … Syndrome of inappropriate antidiuresis (従来のSIADHと同義語) の10～20%の患者において血中AVP濃度は測定感度以下である。 …
NAID 130000077223