Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2014 Dec;178:109-20. doi: 10.1016/j.cbpa.2014.08.015. Epub 2014 Sep 1.
Crustaceans generally act as oxy-regulators, maintaining constant oxygen uptake as oxygen partial pressures decrease, but when a critical low level is reached, ventilation and aerobic metabolism shut down. Cave-adapted animals, including crustaceans, often show a reduced metabolic rate possibly owin
Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5.
Wang J1, Guise CP2, Dachs GU3, Phung Y4, Hsu AH1, Lambie NK5, Patterson AV2, Wilson WR6.
Biochemical pharmacology.Biochem Pharmacol.2014 Oct 15;91(4):436-46. doi: 10.1016/j.bcp.2014.08.003. Epub 2014 Aug 15.
SN30000 is a second-generation benzotriazine-N-oxide hypoxia-activated prodrug scheduled for clinical trial. Previously we showed that covalent binding of the hypoxia probe EF5 predicts metabolic activation of SN30000 in a panel of cancer cell lines under anoxia, suggesting that they are activated b
The Science of the total environment.Sci Total Environ.2014 Oct 15;496:688-700. doi: 10.1016/j.scitotenv.2014.06.117. Epub 2014 Jul 14.
Twin Lakes, located on the Confederated Tribes of the Colville Indian Reservation in eastern Washington, USA, include North Twin Lake (NT) and South Twin Lake (ST). The mesotrophic, dimictic lakes are important recreational fishing sites for both warm-water bass and cold-water trout. To improve summ
ACTUAL SURVEY ON TLm (MEDIAN TOLERANCE LIMIT) VALUES OF ENVIRONMENTAL POLLUTANTS, ESPECIALLY ON AMINES, NITRILES, AROMATIC NITROGEN COMPOUNDS AND ARTIFICIAL DYES
The Journal of Toxicological Sciences 7(3), 193-203, 1982-08-25
Anoxemia is a story-driven exploration game that puts you in control of the scientist Dr. Bailey and his operations drone, ATMA. Search the ocean floor as you discover and extract samples from the bowels of the ...