アネトールトリチオン
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- anetholtrithion
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2019/11/05 23:40:44」(JST)
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Anethole trithione |
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Clinical data |
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ATC code | |
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Identifiers |
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IUPAC name
- 5-(4-methoxyphenyl)-3H-1,2-dithiole-3-thione
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CAS Number | |
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PubChem CID | |
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ChemSpider | |
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KEGG | |
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ChEMBL | |
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CompTox Dashboard (EPA) | |
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ECHA InfoCard | 100.007.754 |
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Chemical and physical data |
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Formula | C10H8OS3 |
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Molar mass | 240.365 g/mol g·mol−1 |
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3D model (JSmol) | |
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SMILES
S=C\2SS/C(c1ccc(OC)cc1)=C/2
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InChI
InChI=1S/C10H8OS3/c1-11-8-4-2-7(3-5-8)9-6-10(12)14-13-9/h2-6H,1H3 Y Key:KYLIZBIRMBGUOP-UHFFFAOYSA-N Y
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Anethole trithione, anetholtrithione, or anetholtrithion (JAN) is a drug used in the treatment of dry mouth. It is listed in the U.S. National Cancer Institute's Dictionary of Cancer Terms as being studied in the treatment of cancer.[1] Anethole trithione is an organosulfur compound, specifically, a dithiole-thione derivative.
Brand names
- Felviten
- Halpen
- Hepasulfol - Franco-Indian Pharmaceuticals
- Heporal
- Mucinol - Sanofi-Aventis
- Sialor - Paladin Laboratories; Pharmascience; Solvay; Zuoz Pharma
- Sonicur - Solvay
- Sulfarlem - Solvay; Aguettant; Edward Keller; Sanofi-Aventis
- Sulfarlem S - EG Labo
- Tiopropen
- Tiotrifar
See also
References
- ^ Anetholtrithione entry in the public domain NCI Dictionary of Cancer Terms. Retrieved September 13, 2008.
Other alimentary tract and metabolism products (A16) |
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Amino acids and derivatives |
- Ademetionine
- Betaine
- Carglumic acid
- Cysteamine
- Levocarnitine
- Levoglutamide
- Metreleptin
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Enzymes |
- Carbohydrate metabolism: sucrase (Sacrosidase)
- alpha-glucosidase (Alglucosidase alfa)
- Glycolipid/sphingolipid: glucocerebrosidase (Alglucerase
- Imiglucerase
- Taliglucerase alfa
- Velaglucerase alfa)
- alpha-galactosidase (Agalsidase alfa
- Agalsidase beta)
- Glycosaminoglycan: iduronidase (Laronidase)
- arylsulfatase B (Galsulfase)
- iduronate-2-sulfatase (Idursulfase)
- Lipid: lysosomal lipase (Sebelipase alfa)
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Other |
- Anethole trithione
- Eliglustat
- Glycerol phenylbutyrate
- Miglustat
- Nitisinone
- Sapropterin
- Sodium benzoate
- Sodium phenylbutyrate
- Teduglutide
- Trientine
- Tioctic acid
- Uridine triacetate
- Zinc acetate
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UpToDate Contents
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English Journal
- An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione.
- Yu HZ, Han SF, Li P, Zhu CL, Zhang XX, Gan L, Gan Y.SourceShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
- Journal of pharmaceutical sciences.J Pharm Sci.2011 Nov;100(11):5048-58. doi: 10.1002/jps.22702. Epub 2011 Jul 15.
- In this study, an examination of the potential effect of lipids on the first-pass metabolism of anethol trithione (ATT) was investigated. ATT is metabolized rapidly and extensively in liver into 4-hydroxy-anethole trithione (ATX), which was confirmed using the rat intestinal perfusion with the mesen
- PMID 21766311
- An HPLC-MS/MS method for the quantitative determination of 4-hydroxy-anethole trithione in human plasma and its application to a pharmacokinetic study.
- He J, Qin T, Wen J, Qin F, Li F.SourceDepartment of Analytical Chemistry, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, PR China.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2011 Feb 20;54(3):551-6. doi: 10.1016/j.jpba.2010.09.037. Epub 2010 Oct 8.
- A selective, rapid and sensitive method for the quantitation of 4-hydroxy-anethole trithione (ATX) in human plasma based on high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed and validated. Paracetamol was used as the internal standard (I.S.). After liquid-liq
- PMID 20980118
- Design, synthesis, and pharmacological evaluation of the aqueous prodrugs of desmethyl anethole trithione with hepatoprotective activity.
- Chen P, Luo Y, Hai L, Qian S, Wu Y.SourceWest China School of Pharmacy, Sichuan University, Chengdu 610041, China.
- European journal of medicinal chemistry.Eur J Med Chem.2010 Jul;45(7):3005-10. doi: 10.1016/j.ejmech.2010.03.029. Epub 2010 Mar 25.
- A metabolite-based prodrug strategy to increase the solubility of anethole trithione was reported to facilitate the clinical application of this hepatoprotective agent. Water-soluble analogs of anethole trithione were synthesized via substituting the methyl group of anethole trithione with the simpl
- PMID 20392547
Japanese Journal
- シェーグレン症候群に伴う口腔乾燥症に対する塩酸ピロカルピンの有効性
- 岩渕 博史,岩渕 絵美,内山 公男
- 日本口腔粘膜学会雑誌 = Journal of Japanese Society for Oral Mucous Membrane 14(2), 31-38, 2008-12-30
- シェーグレン症候群(以下SS)に伴う口腔乾燥症の治療薬として新規承認された塩酸ピロカルピンの投与効果および副作用について検討した。対象は2007年10月~2008年5月までに本剤を投与した症例中,塩酸セビメリンやアネトールトリチオンによる治療歴がなく投与4週後の評価が行えた30例である。10分間ガムテスト値は投与前に比べ投与開始4週後以降では有意に増加したが,自覚症状スコアでは有意な …
- NAID 10025567720
- 唾液分泌低下-その原因と唾液分泌低下に伴う口腔障害
- 植田 栄作,木村 剛,谷田 豊宏,岡本 哲郎,岡本 敦子,森 仁志,山本 哲也,尾崎 登喜雄
- 日本口腔科学会雜誌 52(5), 227-234, 2003-09-10
- NAID 10014354043
- Enhancement of salivary secretion and neuropeptide (substance P, α-calcitonin gene-related peptide) levels in saliva by chronic anethole trithione treatment
Related Links
- 1. Am J Med Sci. 1999 Sep;318(3):146-51. Treatment of xerostomia with the bile secretion-stimulating drug anethole trithione: a clinical trial. Hamada T(1), Nakane T, Kimura T, Arisawa K, Yoneda K, Yamamoto T, Osaki ...
- Anethole Trithione information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Anethole Trithione Description of Anethole Trithione Anethole Trithione: Choleretic ...
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アネトールトリチオン
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- anethole trithione