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generalized edema with accumulation of serum in subcutaneous connective tissue

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/12 16:18:24」(JST)

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Anasarca, or extreme generalized edema, is a medical condition characterized by widespread swelling of the skin due to effusion of fluid into the extracellular space.^[1]

It is usually caused by liver failure (cirrhosis of the liver), renal failure/disease, right-sided heart failure, as well as severe malnutrition/protein deficiency. The increase in salt and water retention caused by low cardiac output can also result in anasarca as a long term maladaptive response.

It can also be created from the administration of exogenous intravenous fluid. Certain plant-derived anticancer chemotherapeutic agents, such as docetaxel, cause anasarca through a poorly understood capillary leak syndrome.^[2]

In Hb Barts, the high oxygen affinity results in poor oxygen delivery to peripheral tissues, resulting in anasarca.

References

^ Kumar Vinay. Robbins and Coltran pathologic basis of disease. 8th ed. p.112; Philadelphia: Saunders Elsevier, 2010. ISBN 978-0-8089-2402-9
^ Semb K A, Aamdal S, Oian P. "Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment". Journal of Clinical Oncology. October 1998. vol. 16 no. 10 3426-3432

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1. 成人における浮腫の臨床症状および診断 clinical manifestations and diagnosis of edema in adults
2. 成人における浮腫に対する治療の一般原則 general principles of the treatment of edema in adults
3. 小児におけるネフローゼ症候群の合併症 complications of nephrotic syndrome in children
4. 成人における難治性浮腫の治療 treatment of refractory edema in adults
5. 小児における浮腫の病態生理および病因 pathophysiology and etiology of edema in children

English Journal

Development of a mouse model for sulfur mustard-induced ocular injury and long-term clinical analysis of injury progression.

Ruff AL, Jarecke AJ, Hilber DJ, Rothwell CC, Beach SL, Dillman JF 3rd.SourceUSAMRICD, Cellular and Molecular Biology, Gunpowder 21010, USA. albert.leonard.ruff@us.army.mil
Cutaneous and ocular toxicology.Cutan Ocul Toxicol.2013 Jun;32(2):140-9. doi: 10.3109/15569527.2012.731666. Epub 2012 Oct 30.
CONTEXT: Sulfur mustard (SM) is a highly reactive vesicating agent that can induce severe ocular injury. The clinical features of this injury have been well documented, but the molecular basis for this pathology is not well understood. Identification and validation of specific targets is necessary i
PMID 23106216

Endothelial cell damage following sulfur mustard exposure in rabbits and its association with the delayed-onset ocular lesions.

Kadar T, Cohen M, Cohen L, Fishbine E, Sahar R, Brandeis R, Dachir S, Amir A.SourceDepartment of Pharmacology, Israel Institute for Biological Research, Ness-Ziona, Israel. tamark@iibr.gov.il
Cutaneous and ocular toxicology.Cutan Ocul Toxicol.2013 Jun;32(2):115-23. doi: 10.3109/15569527.2012.717571. Epub 2012 Oct 30.
OBJECTIVE: Ocular injuries following exposure to the toxic agent sulfur mustard (SM) are characterized by acute corneal erosions and inflammation of the anterior segment that may be followed by delayed corneal injuries, expressed clinically by neovascularization and epithelial defects. The present s
PMID 23106194

Dermal and ocular irritation and skin sensitization studies of fullerene C60 nanoparticles.

Ema M, Matsuda A, Kobayashi N, Naya M, Nakanishi J.SourceResearch Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology, Onogawa, Tsukuba, Ibaraki, Japan. ema-makoto@aist.go.jp
Cutaneous and ocular toxicology.Cutan Ocul Toxicol.2013 Jun;32(2):128-34. doi: 10.3109/15569527.2012.727937. Epub 2012 Oct 11.
CONTEXT: Widespread production and use of nanomaterials have caused the release of increasing amounts of nanomaterials into the environment. The introduction of novel materials into industry requires safety evaluations as well as an understanding of the impact of the nanomaterials on human health, b
PMID 23050631

Japanese Journal

胸腹水と血小板減少を伴った多中心性Castleman病のー亜型 : 新規疾患概念TAFRO症候群

正木康史
血液内科 68(1), 97-102, 2014-01
NAID 40019971760

Castleman-Kojima Disease in a South Asian Adolescent

Koduri Prasad R.,Parvez Mohammed,Kaza Sashidhar,Pappu Prabhakar,Anuradha Sekaran
Journal of Clinical and Experimental Hematopathology 54(2), 163-166, 2014
NAID 130004699342

重度貧血の補正によりposterior reversible encephalopathy syndromeを生じ，血圧正常にもかかわらず脳出血を続発，脂溶性ビタミン欠乏症の関与が考えられた1例

白石渉,宇根隼人,岩永育貴,山本明史
臨床神経学 54(6), 518-521, 2014
症例は36歳女性である．即席麺やスナック菓子ばかり食べていた．4年前から下腿浮腫を自覚するも放置していた．来院18日前に全身浮腫と体動困難を生じ前医受診，Hb 1.4 g/dlの貧血と心拡大をみとめ，重度貧血にともなう心不全として輸血加療され改善し前医を退院．翌日夜に痙攣を生じ当院に救急搬送．頭部MRI画像からposterior reversible encephalopathy syndrome …
NAID 130004505595

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「全身性浮腫」

Anasarca
	A child suffering from anasarca brought on by nephrosis associated with malaria
ICD-10	R60.1
ICD-9	782.3
DiseasesDB	9148
MedlinePlus	003103
MeSH	D004487

　　[★]

英: generalized edema, anasarca
同: 全身浮腫、全身水腫
関: 浮腫

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全身水腫 : 約 1,270 件
全身性水腫 : 28 件
全身性浮腫 : 約 166,000 件
全身浮腫 : 約 9,310 件

胸腔・腹腔を含めて全身の組織間隙に及んだ著しい浮腫

[1] Kumar Vinay. Robbins and Coltran pathologic basis of disease. 8th ed. p.112; Philadelphia: Saunders Elsevier, 2010. ISBN 978-0-8089-2402-9

[2] Semb K A, Aamdal S, Oian P. "Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment". Journal of Clinical Oncology. October 1998. vol. 16 no. 10 3426-3432

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anasarca