アナフィラトキシン不活性化因子
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/19 08:47:28」(JST)
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| Lysine carboxypeptidase |
| Identifiers |
| EC number |
3.4.17.3 |
| CAS number |
9013-89-2 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
Lysine carboxypeptidase (EC 3.4.17.3, carboxypeptidase N, arginine carboxypeptidase, kininase I, anaphylatoxin inactivator, plasma carboxypeptidase B, creatine kinase conversion factor, bradykinase, kininase Ia, hippuryllysine hydrolase, bradykinin-decomposing enzyme, protaminase, CPase N, creatinine kinase convertase, peptidyl-L-lysine(-L-arginine) hydrolase, CPN) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Release of a C-terminal basic amino acid, preferentially lysine
This is a zinc enzyme found in plasma. It inactivates bradykinin and anaphylatoxins.
References[edit]
- ^ Plummer, T.H., Jr. and Erdös, E.G. (1981). "Human plasma carboxypeptidase N". Methods Enzymol. 80: 442–449. PMID 7341915.
- ^ Levin, Y., Skidgel, R.A. and Erdös, E.G. (1982). "Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase I)". Proc. Natl. Acad. Sci. USA 79: 4618–4622. PMID 6750606.
- ^ Skidgel, R.A. (1988). "Basic carboxypeptidases: regulators of peptide hormone activity". Trends Pharmacol. Sci. 9: 301–303. PMID 3074547.
External links[edit]
- Lysine carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Culture temperature modulates monoclonal antibody charge variation distribution in Chinese hamster ovary cell cultures.
- Zhang X1, Sun YT2, Tang H3, Fan L4, Hu D5, Liu J6, Liu X7, Tan WS8.
- Biotechnology letters.Biotechnol Lett.2015 Nov;37(11):2151-7. doi: 10.1007/s10529-015-1904-3. Epub 2015 Jul 7.
- OBJECTIVE: To investigate the effect of lowering culture temperature on monoclonal antibody charge variation distribution in Chinese hamster ovary cell cultures.RESULTS: In both batch and fed-batch cultures, lowering the culture temperature decreased the antibody acidic variant levels. The acidic va
- PMID 26149578
- A Novel ¹¹¹In-Labeled Anti-Prostate-Specific Membrane Antigen Nanobody for Targeted SPECT/CT Imaging of Prostate Cancer.
- Chatalic KL1, Veldhoven-Zweistra J2, Bolkestein M3, Hoeben S2, Koning GA3, Boerman OC4, de Jong M5, van Weerden WM2.
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine.J Nucl Med.2015 Jul;56(7):1094-9. doi: 10.2967/jnumed.115.156729. Epub 2015 May 14.
- Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer (PCa) and a promising target for molecular imaging and therapy. Nanobodies (single-domain antibodies, VHH) are the smallest antibody-based fragments possessing ideal molecular imaging properties, such as high target specif
- PMID 25977460
- Nicotianamine is a novel angiotensin-converting enzyme 2 inhibitor in soybean.
- Takahashi S1, Yoshiya T, Yoshizawa-Kumagaye K, Sugiyama T.
- Biomedical research (Tokyo, Japan).Biomed Res.2015;36(3):219-24. doi: 10.2220/biomedres.36.219.
- Angiotensin-converting enzyme 2 (ACE2) is a carboxypeptidase which is highly homologous to angiotensin-converting enzyme (ACE). ACE2 produces vasodilator peptides angiotensin 1-7 from angiotensin II. In the present study, we synthesized various internally quenched fluorogenic (IQF) substrates (fluor
- PMID 26106051
Japanese Journal
- Inability of rat anaphylatoxin to induce histamine release in rats.
- Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase
- Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity anddescription of an anaphylatoxin inactivator of human serum
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