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This article needs more medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be removed. (November 2012) |
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| Myotonia |
| Classification and external resources |
| Specialty |
neurology |
| ICD-10 |
G71.1 |
| ICD-9-CM |
359.2 |
| DiseasesDB |
23079 |
| MeSH |
D009222 |
Myotonia (Myo from Greek; muscle, and Tonus from Latin; tension) is a symptom of a small handful of certain neuromuscular disorders characterized by delayed relaxation (prolonged contraction) of the skeletal muscles after voluntary contraction or electrical stimulation.[1]
Myotonia is present in Myotonia congenita, Paramyotonia Congenita and myotonic dystrophy.
Generally, repeated contraction of the muscle can alleviate the myotonia and relax the muscles thus improving the condition, however this is not the case in Paramyotonia congenita. This phenomenon is known as "Warm-Up"[2] and is not to be confused with warming up before exercise, though they may appear similar. Individuals with the disorder may have trouble releasing their grip on objects or may have difficulty rising from a sitting position and a stiff, awkward gait.
Myotonia can affect all muscle groups; however, the pattern of affected muscles can vary depending on the specific disorder involved.
People suffering from disorders involving myotonia can have a life-threatening reaction to certain anaesthetics; one of these conditions occurs when the patient is under anaesthetic and is termed "Malignant hyperthermia".
Contents
- 1 Causes
- 1.1 Myotonic muscular dystrophy
- 1.2 Myotonia Congenita
- 1.3 Paramyotonia Congenita
- 2 See also
- 3 External links
- 4 References
Causes
Myotonia may present in the following diseases with different causes related to the ion channels in the skeletal muscle fiber membrane (Sarcolemma).
Myotonic muscular dystrophy
Two documented types, DM1 and DM2 exist. In myotonic dystrophy a nucleotide expansion of either of two genes, related to type of disease, results in failure of correct expression (splicing of the mRNA) of the ClC-1 ion channel, due to accumulation of RNA in the cyotsol of the cell.[3][4] The ClC-1 ion channel is responsible for the major part of chloride conductance in the skeletal muscle cell,[5] and lack of sufficient chloride conductance may result in myotonia, (see myotonia congenita). When the splicing of the mRNA was corrected in vitro, ClC-1 channel function was greatly improved and myotonia was abolished.[6]
Myotonia Congenita
(Congenital Myotonia) of which two types called Becker's Disease and Thomsen's Disease exist.[7] Both diseases are caused by mutations in the gene CLCN1 encoding the ClC-1 ion channel. More than 130 different mutations exist in total, and a large phenotypic variation is therefore present in this disease.[8] The mutations are loss-of-function mutations that render the ClC-1 ion channel dysfunctional to varying degrees, with reduced chloride conductance as a result. Reduced chloride conductance may result in myotonia, due to accumulation of potassium in the transverse-tubules in skeletal muscle (see myotonia congenita).
Symptoms of myotonia (documented in myotonia conganita) are more frequently experienced in women during pregnancy.[9]
Paramyotonia Congenita
This disease results from mutation in the SCN4A gene encoding the voltage-gated sodium channel Nav1.4 in skeletal muscle fiber membrane. Mutations may alter the kinetics of the channel, such that the channel fails to inactivate properly, thus allowing spontaneous action potentials to occur after voluntary activity has terminated, prolonging relaxation of the muscle, or can result in paralysis if the relaxation is severely prolonged (see SCN4A).
See also
- Myotonia congenita
- Potassium-aggravated myotonia
- Myotonic dystrophy
- Fainting goat
External links
- myotonia at NINDS
- National Registry of Myotonic Dystrophy
- Myotonic Dystrophy Foundation
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Diseases of myoneural junction and muscle / neuromuscular disease (G70–G73, 358–359)
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Neuromuscular-
junction disease |
- autoimmune
- Myasthenia gravis
- Lambert–Eaton myasthenic syndrome
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Myopathy/
congenital myopathy |
Muscular dystrophy
(DAPC) |
| AD |
- Limb-girdle muscular dystrophy 1
- Oculopharyngeal
- Facioscapulohumeral
- Myotonic
- Distal (most)
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| AR |
- Limb-girdle muscular dystrophy 2
- Congenital
- Fukuyama
- Ullrich
- Walker–Warburg
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| XR |
- dystrophin
- Emery–Dreifuss
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| Other structural |
- collagen disease
- PTP disease
- adaptor protein disease
- BIN1-linked centronuclear myopathy
- cytoskeleton disease
- Nemaline myopathy
- Zaspopathy
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| Channelopathy |
| Myotonia |
- Myotonia congenita
- Thomsen disease
- Neuromyotonia/Isaacs syndrome
- Paramyotonia congenita
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| Periodic paralysis |
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| Other |
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| Mitochondrial myopathy |
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| Other |
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Index of muscle
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|
| Description |
- Anatomy
- head
- neck
- arms
- chest and back
- diaphragm
- abdomen
- genital area
- legs
- Muscle tissue
- Physiology
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| Disease |
- Myopathy
- Soft tissue
- Connective tissue
- Congenital
- abdomen
- muscular dystrophy
- Neoplasms and cancer
- Injury
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- anti-inflammatory
- muscle relaxants
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References
- ^ Gutmann, L; Phillips LH, 2nd (September 1991). "Myotonia congenita.". Seminars in neurology 11 (3): 244–8. doi:10.1055/s-2008-1041228. PMID 1947487.
- ^ Birnberger, KL; Rüdel, R; Struppler, A (1 September 1975). "Clinical and electrophysiological observations in patients with myotonic muscle disease and the therapeutic effect of N-propyl-ajmalin.". Journal of neurology 210 (2): 99–110. doi:10.1007/BF00316381. PMID 51920.
- ^ Mankodi, A; Takahashi, MP; Jiang, H; Beck, CL; Bowers, WJ; Moxley, RT; Cannon, SC; Thornton, CA (Jul 2002). "Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy.". Molecular Cell 10 (1): 35–44. doi:10.1016/s1097-2765(02)00563-4. PMID 12150905.
- ^ Charlet-B, N; Savkur, RS; Singh, G; Philips, AV; Grice, EA; Cooper, TA (Jul 2002). "Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing.". Molecular Cell 10 (1): 45–53. doi:10.1016/s1097-2765(02)00572-5. PMID 12150906.
- ^ Kwieciński, H; Lehmann-Horn, F; Rüdel, R (Jan 1984). "The resting membrane parameters of human intercostal muscle at low, normal, and high extracellular potassium.". Muscle & nerve 7 (1): 60–5. doi:10.1002/mus.880070110. PMID 6700631.
- ^ Wheeler, TM; Lueck, JD; Swanson, MS; Dirksen, RT; Thornton, CA (December 2007). "Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy.". The Journal of Clinical Investigation 117 (12): 3952–7. doi:10.1172/JCI33355. PMC 2075481. PMID 18008009. Retrieved 5 August 2013.
- ^ Lossin, Christoph; George AL jr (2008). "Myotonia Congenita". Advances in genetics 63: 25–55. doi:10.1016/S0065-2660(08)01002-X. PMID 19185184.
- ^ Colding-Jørgensen, Eskild (Jul 2005). "Phenotypic variability in myotonia congenita". Muscle & nerve 32 (1): 19–34. doi:10.1002/mus.20295. PMID 15786415.
- ^ Basu, A; Nishanth, P; Ifaturoti, O (Jul 2009). "Pregnancy in women with myotonia congenita.". International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 106 (1): 62–3. doi:10.1016/j.ijgo.2009.01.031. PMID 19368920.
