音痴、失音楽症

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/19 16:16:28」(JST)

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Amusia is a musical disorder that appears mainly as a defect in processing pitch, but it also encompasses musical memory and recognition.^[1] Two main classifications of amusia exist: acquired amusia, which occurs as a result of brain damage, and congenital amusia, which results from a music processing anomaly at birth.

Studies have shown that congenital amusia is a deficit in fine-grained pitch discrimination and that 4% of the population suffers from this disorder.^[2] Acquired amusia, on the other hand, may take several forms. Patients with brain damage may experience the loss of ability to produce musical sounds while sparing speech,^[3] much like aphasics lose speech selectively but can sometimes still sing.^[4]^[5] Other forms of amusia may affect specific sub-processes of music processing. Current research has demonstrated dissociations between rhythm, melody, and emotional processing of music,^[6] and amusia may include impairment of any combination of these skill sets.

1 Basics of music processing
2 Symptoms
3 Diagnosis
4 Classifications
- 4.1 Congenital amusia
- 4.2 Acquired amusia
5 Neuroanatomy
- 5.1 Overview
- 5.2 Pitch relations
- 5.3 Temporal relations
- 5.4 Memory
- 5.5 Other regions of the brain possibly linked to amusia
6 Discovery
7 Interesting case studies
- 7.1 First documented case of congenital amusia
- 7.2 Family aggregation study
- 7.3 Singing in congenital amusia
8 Related diseases
9 Social and emotional impact
10 Treatment
11 Future research
12 Famous sufferers
13 See also
14 References
15 Further reading
16 External links

Basics of music processing[edit]

Neurologically intact individuals appear to be born musical. Even before they are able to talk, infants show remarkable musical abilities that are similar to those of adults in that they are sensitive to musical scales and a regular tempo.^[2] Also, infants are able to differentiate between consonant and dissonant intervals. These perceptual skills indicate that music-specific predispositions exist.^[2]

Prolonged exposure to music develops and refines these skills. Extensive musical training does not seem to be necessary in the processing of chords and keys.^[2] The development of musical competence most likely depends on the encoding of pitch along musical scales and maintaining a regular pulse, both of which are key components in the structure of music and aid in perception, memory, and performance.^[2] Also, the encoding of pitch and temporal regularity are both likely to be specialized for music processing.^[2] Pitch perception is absolutely crucial to processing music. The use of scales and the organization of scale tones around a central tone (called the tonic) assign particular importance to notes in the scale and cause non-scale notes to sound out of place. This enables the listener to ascertain when a wrong note is played. However, in individuals with amusia, this ability is either compromised or lost entirely.^[2]

Music-specific neural networks exist in the brain for a variety of music-related tasks. It has been shown that Broca's area is involved in the processing of musical syntax.^[7] Furthermore, brain damage can disrupt an individual's ability to tell the difference between tonal and atonal music and detect the presence of wrong notes, but can preserve the individual's ability to assess the distance between pitches and the direction of the pitch.^[2] The opposite scenario can also occur, in which the individual loses pitch discrimination capabilities, but can sense and appreciate the tonal context of the work. Distinct neural networks also exist for music memories, singing, and music recognition. Neural networks for music recognition are particularly intriguing. A patient can undergo brain damage that renders him/her unable to recognize familiar melodies that are presented without words. However, the patient maintains the ability to recognize spoken lyrics or words, familiar voices, and environmental sounds.^[2] The reverse case is also possible, in which the patient cannot recognize spoken words, but can still recognize familiar melodies. These situations overturn previous claims that speech recognition and music recognition share a single processing system.^[2] Instead, it is clear that there are at least two distinct processing modules: one for speech and one for music.^[2]

Symptoms[edit]

Symptoms of amusia are generally categorized as receptive, clinical, or mixed. Symptoms of receptive amusia, sometimes referred to as "musical deafness", include the inability to recognize familiar melodies, the loss of ability to read musical notation, and the inability to detect wrong or out-of tune notes.^[8] Clinical, or expressive, symptoms include the loss of ability to sing, write musical notation, and/or play an instrument.^[9] A mixed disorder would be a combination of expressive and receptive impairment.

Clinical symptoms of acquired amusia are much more variable than those of congenital amusia and are determined by the location and nature of the lesion.^[8] Brain injuries may afflict motor or expressive functioning, including the ability to sing, whistle, or hum a tune (oral-expressive amusia), the ability to play an instrument (instrumental amusia or musical apraxia), and the ability to write music (musical agraphia). Additionally, brain damage to the receptive dimension affects the faculty to discriminate tunes (receptive or sensorial amusia), the ability to read music (musical alessia), and the ability to identify songs that were familiar prior to the brain damage (amnesic amusia).

Research suggests that patients with amusia also have difficulty when it comes to spatial processing.^[10] Amusics performed more quickly than normal individuals on a combined task of both spatial and musical processing tasks, which is most likely due to their deficit. Normal individuals experience interference due to their intact processing of both musical and spatial tasks, while amusics do not.^[10] Pitch processing normally depends on the cognitive mechanisms that are usually used to process spatial representations.^[10]

Those with congenital amusia show impaired performance on discrimination, identification and imitation of sentences with intonational differences in pitch direction in their final word. This suggests that amusia can in subtle ways impair language processing.^[11]

Diagnosis[edit]

The diagnosis of amusia requires individuals to detect out-of-key notes in conventional but unfamiliar melodies.^[12] A behavioral failure on this test is diagnostic because there is typically no overlap between the distributions of the scores of amusics and controls.^[13] Such scores are generally obtained through the Montreal Battery of Evaluation of Amusia (MBEA),^[14] which involves a series of tests that evaluate the use of musical characteristics known to contribute to the memory and perception of conventional music.^[15] The battery comprises six subtests which assess the ability to discriminate pitch contour, musical scales, pitch intervals, rhythm, meter, and memory.^[2] An individual is considered amusic if he/she performs two standard deviations below the mean obtained by musically-competent controls. This musical pitch disorder represents a phenotype that serves to identify the associated neuro-genetic factors.^[16] Both MRI-based brain structural analyses and electroencephalography (EEG) are common methods employed to uncover brain anomalies associated with amusia (See Neuroanatomy).^[12] Additionally, voxel-based morphometry (VBM) is used to detect anatomical differences between the MRIs of amusic brains and musically intact brains, specifically with respect increased and/or decreased amounts of white and grey matter.^[12]

Classifications[edit]

There are two general classifications of amusia: congenital amusia and acquired amusia.

Congenital amusia[edit]

Congenital amusia, commonly known as tone deafness,^[16] refers to a musical disability that cannot be explained by prior brain lesion, hearing loss, cognitive defects, or lack of environmental stimulation,^[15] and it affects about 4% of the population.^[2] Individuals who suffer from congenital amusia seem to lack the musical predispositions that most people are born with.^[17] They are unable to recognize or hum familiar tunes even though they have normal audiometry and above average intellectual and memory skills.^[2] Also, they do not show sensitivity to dissonant chords in a melodic context, which, as discussed earlier, is one of the musical predispositions exhibited by infants.^[2] The hallmark of congenital amusia is a deficit in fine-grained pitch discrimination, and this deficit is most apparent when congenital amusics are asked to pick out a wrong note in a given melody.^[2] If the distance between two successive pitches is small, congenital amusics are not able to detect a pitch change. As a result of this defect in pitch perception, a lifelong musical impairment may emerge due to a failure to internalize musical scales. A lack of fine-grained pitch discrimination makes it extremely difficult for amusics to enjoy and appreciate music, which consists largely of small pitch changes.^[17]

Acquired amusia[edit]

Acquired amusia is a musical disability that shares the same characteristics as congenital amusia, but rather than being inherited, it is the result of brain damage.^[18] It is also more common than congenital amusia.^[18] While it has been suggested that music is processed by music-specific neural networks in the brain, this view has been broadened to show that music processing also encompasses generic cognitive functions, such as memory, attention, and executive processes.^[18] A recent study was conducted to investigate the neural and cognitive mechanisms that underlie acquired amusia and contribute to its recovery.^[18] The study was performed on 53 stroke patients with a left or right hemisphere middle cerebral artery (MCA) infarction one week, three months, and six months after the stroke occurred.^[18] Amusic subjects were identified one week following their stroke, and over the course of the study, amusics and non-amusics were compared in both brain lesion location and their performances on neuropsychological tests.

Results showed that there was no significant difference in the distribution of left and right hemisphere lesions between amusic and non-amusic groups, but that the amusic group had a significantly higher number of lesions to the frontal lobe and auditory cortex.^[18] Temporal lobe lesions were also observed in patients with amusia. Amusia is a common occurrence following an ischemic MCA stroke, as evidenced by the 60% of patients who were found to be amusic at the one week post-stroke stage.^[18] While significant recovery takes place over time, amusia can persist for long periods of time.^[18] Test results suggest that acquired amusia and its recovery in the post-stroke stage are associated with a variety of cognitive functions, particularly attention, executive functioning, and working memory.^[18]

Neuroanatomy[edit]

Overview[edit]

Many research studies of individuals with amusia show that a number of cortical regions appear to be involved in processing music. Some report that the primary auditory cortex, secondary auditory cortex, and limbic system are responsible for this faculty, while more recent studies suggest that lesions in other cortical areas, abnormalities in cortical thickness, and deficiency in neural connectivity and brain plasticity may contribute to amusia. While various etiologies of amusia exist, some general findings that provide insight to the brain mechanisms involved in music processing are discussed below.^[8]

Pitch relations[edit]

Studies suggest that the analysis of pitch is primarily controlled by the right temporal region of the brain. The right secondary auditory cortex processes pitch change and manipulation of fine tunes; specifically, this region distinguishes the multiple pitches that characterize melodic tunes as contour (pitch direction) and interval (frequency ratio between successive notes) information.^[19] The right superior temporal gyrus recruits and evaluates contour information, while both right and left temporal regions recruit and evaluate interval information.^[20] In addition, the right anterolateral part of Heschl's gyrus (primary auditory cortex) is also concerned with processing pitch information.^[21]

Temporal relations[edit]

The brain analyzes the temporal (rhythmic) components of music in two ways: (1) it segments the ongoing sequences of music into temporal events based on duration, and (2) it groups those temporal events to understand the underlying beat to music. Studies on rhythmic discrimination reveal that the right temporal auditory cortex is responsible for temporal segmenting, and the left temporal auditory cortex is responsible for temporal grouping.^[22]^[23] Other studies suggest the participation of motor cortical areas in rhythm perception and production.^[24] Therefore, a lack of involvement and networking between bilateral temporal cortices and neural motor centers may contribute to both congenital and acquired amusia.^[8]

Memory[edit]

Memory is required in order to process and integrate both melodic and rhythmic aspects of music. Studies suggest that there is a rich interconnection between the right temporal gyrus and frontal cortical areas for working memory in music appreciation.^[25]^[26] This connection between the temporal and frontal regions of the brain is extremely important since these regions play critical roles in music processing. Changes in the temporal areas of the amusic brain are most likely associated with deficits in pitch perception and other musical characteristics, while changes in the frontal areas are potentially related to deficits in cognitive processing aspects, such as memory, that are needed for musical discrimination tasks.^[18] Memory is also concerned with the recognition and internal representation of tunes, which help to identify familiar songs and confer the ability to sing tunes in one's head. The activation of the superior temporal region and left inferior temporal and frontal areas is responsible for the recognition of familiar songs,^[20] and the right auditory cortex (a perceptual mechanism) is involved in the internal representation of tunes.^[27] These findings suggest that any abnormalities and/or injuries to these regions of the brain could facilitate amusia.

Discovery[edit]

In 1825, F. Gall mentioned a "musical organ" in a specific region of the human brain that could be spared or disrupted after a traumatic event resulting in brain damage.^[29] In 1865, Jean-Baptiste Bouillaud described the first series of cases that involved the loss of music abilities that were due to brain injury. Later, during the late nineteenth-century, several influential neurologists studied language in an attempt to construct a theory of cognition. While not studied as thoroughly as language, music and visual processing were also studied. In 1888-1890, August Knoblauch produced a cognitive model for music processing and termed it amusia. This model for music processing was the earliest produced.^[30]

Interesting case studies[edit]

First documented case of congenital amusia[edit]

While the possibility that certain individuals may be born with musical deficits is not a new notion, the first documented case of congenital amusia was published relatively recently.^[15] The study was conducted with a female volunteer, referred to as Monica, who declared herself to be musically impaired in response to an advertisement in the newspaper.^[15] Monica had no psychiatric or neurological history, nor did she have any hearing loss. MRI scans showed no abnormalities. Monica also scored above average on a standard intelligence test, and her working memory was evaluated and found to be normal. However, Monica suffers from a lifelong inability to recognize or perceive music, which has persisted even after involvement with music through church choir and band during her childhood and teenage years.^[15] Monica even admits that she does not enjoy listening to music because, to her, it sounds like noise and evokes a stressful response.

In order to determine if Monica's disorder is amusia, she was subjected to the MBEA series of tests. One of the tests dealt with Monica's difficulties in discriminating pitch variations in sequential notes. In this test, a pair of melodies was played, and Monica was asked if the second melody in the pair contained a wrong note.^[15] Monica's score on this test was well below the average score generated by the control group.^[15] Further tests showed that Monica struggles with recognizing highly familiar melodies, but that she has no problems in recognizing the voices of well-known speakers. Thus, it appears that Monica's deficit seems limited to music.^[15] Interestingly, a later study showed that not only do amusics experience difficulty in discriminating variations in pitch, but they also exhibit deficits in perceiving patterns in pitch.^[31]

This finding led to another test that was designed to assess the presence of a deficiency in pitch perception.^[15] In this test, Monica heard a sequence of five piano tones of constant pitch followed by a comparison sequence of five piano tones in which the fourth tone could be the same pitch as the other notes in the sequence or a completely different pitch altogether. Monica was asked to respond "yes" if she detected a pitch change on the fourth tone or respond "no" if she could not detect a pitch change. Results show that Monica could barely detect a pitch change as large as two semitones (whole tone), or half steps.^[15] While this pitch-processing deficit is extremely severe, it does not seem to include speech intonation.^[15] This is because pitch variations in speech are very coarse compared with those used in music.^[2] In conclusion, Monica's learning disability arises from a basic problem in pitch discrimination, which is viewed as the origin of congenital amusia.^[15]

Family aggregation study[edit]

Another interesting question posed about congenital amusia is if it has a genetic origin.^[16] A study was conducted to test for the presence of a genetic origin by studying family aggregation of congenital amusia.^[16] Family members of amusics were studied, as well as family members of a control group. The study yielded interesting results. Amusia cannot be attributed solely to family environment due to the presence of at least one unaffected sibling in each tested family in the amusic group.^[16] Also, music was found to be present to a lesser extent, but not absent, in the environment of the amusic subjects than in that of the musically intact control group.^[16] This supports the claim that the occurrence of congenital amusia cannot be explained by a lack of environmental stimulation. Another interesting finding was that the next generation, or the offspring of those with congenital amusia, was more musical.^[16] A reason for this might be that musical stimulation for the offspring probably started early in life when their brains were more plastic.^[16]

Overall, test results support the view that congenital amusia is hereditary.^[16] It is likely to be influenced by several genes that interact to increase an individual's susceptibility to its development.^[16] However, the fact that the offspring have a lower risk of developing congenital amusia shows that it can be less prevalent when the musical environment is enriched.^[16] This stresses the importance that experience-dependent tuning has in the musical pitch system.^[16]

Singing in congenital amusia[edit]

While it is known that congenital amusia is a disorder characterized by poor pitch perception, a recent study sought to discover to what extent this pitch deficit may compromise singing.^[32] In this study, eleven amusic individuals and eleven controls were asked to sing a familiar song using the lyrics first, and then using the syllable "la". Results showed that individuals with congenital amusia were poor singers.^[32] They could not maintain a stable pitch, nor could they sing the correct pitch intervals that were written in the music. However, many of the amusic testing subjects were able to sing with the correct rhythm.^[32] The results confirmed that the amusics' ability to detect pitch changes influences their level of singing proficiency.^[32] The subjects who struggled the most with pitch perception were the most unstable in producing the correct pitch and made several pitch interval and contour errors. However, there were some remarkable exceptions. A couple of amusic individuals were able to sing proficiently despite extremely impaired pitch perception.^[32]

It is also interesting to compare the results of singing with the lyrics and singing on the syllable "la". Although most of the amusic subjects struggled with maintaining the correct pitch when singing with lyrics, they were able to complete the task. However, when singing the same song on the syllable "la", more than half of the amusic subjects could only sing a few notes.^[32] This is due to a poor memory of the musical component of songs.^[32] Overall, it was concluded that singing deficiency in amusic individuals might be a result of their pitch perception deficit.^[32] However, the existence of amusic individuals who are able to sing proficiently suggests that there may be separate neural pathways for auditory perception and action.^[32]

Related diseases[edit]

Main article: Music-specific disorders

Amusia has recently been classified as a learning disability that affects musical abilities.^[33] Research suggests that in congenital amusia, younger subjects can be taught tone differentiation techniques. This finding leads researchers to believe that amusia is related to dyslexia and other similar disorders.^[34] Research has been shown that amusia may be related to an increase in size of the cerebral cortex, which may be a result of a malformation in cortical development. Diseases such as dyslexia and epilepsy are due to a malformation in cortical development and also lead to an increase in cortical thickness, which leads researchers to believe that congenital amusia may be caused by the identical phenomenon in a different area of the brain.^[35]

Amusia is also similar to aphasia in that they affect similar areas of the brain near the temporal lobe. Most cases of those with amusia do not show any symptoms of aphasia. However, a number of cases have shown that those who have aphasia can exhibit symptoms of amusia, especially in acquired aphasia. The two are not mutually exclusive and having one does not imply possession of the other.^[33] In acquired amusia, inability to perceive music correlates with an inability to perform other higher-level functions. As musical ability improves, so too do the higher cognitive functions which suggests that musical ability is closely related to these higher-level functions, such as memory and learning, mental flexibility, and semantic fluency.^[18]

Amusia can also be related to aprosody, a disorder in which the sufferer's speech is affected, becoming extremely monotonous. It has been found that both amusia and aprosody can arise from seizures occurring in the non-dominant hemisphere.^[36] They can also both arise from lesions to the brain, as can Broca's aphasia come about simultaneously with amusia from injury.^[36] There is a relation between musical abilities and the components of speech, however, they are not understood very well.^[36]

Social and emotional impact[edit]

Other than their inability to hear music, which is most likely due to a genetic defect, the rest of an amusic's brain remains normal. The only effect is on the ability to tell different notes apart due to the separation of two key areas in the brain. Most sufferers of amusia describe music as unpleasant. Others simply refer to it as noise and find it annoying. This can have social implications because amusics often try to avoid music, which in many social situations is not an option. In China and other countries in which identical words have different meanings based on pitch, amusia may have a much more pronounced social and emotional impact; difficulty in speaking and understanding the language.^[37]

Treatment[edit]

Currently, no forms of treatment have proven effective in treating amusia. One study has shown tone differentiation techniques to have some success, however future research on treatment of this disorder will be necessary to verify this technique as an appropriate treatment.^[33]

Future research[edit]

Over the past decade, much has been discovered about amusia. However, there remains a great deal more to learn. While a method of treatment for people with amusia has not been defined, tone differentiation techniques have been used on amusic patients with some success. It was found with this research that children reacted positively to these tone differentiation techniques, while adults found the training annoying.^[33] However, further research in this direction would aid in determining if this would be a viable treatment option for people with amusia. Additional research can also serve to indicate which processing component in the brain is essential for normal music development.^[15] Also, it would be extremely beneficial to investigate musical learning in relation to amusia since this could provide valuable insights into other forms of learning disabilities such as dysphasia and dyslexia.^[13]^[15]

Famous sufferers[edit]

Theodore Roosevelt^[38]
Che Guevara^[38]
Milton Friedman^{[citation needed]}
Sigmund Freud^{[citation needed]}
Ulysses S. Grant^[38]
Charles Darwin^{[citation needed]}

References[edit]

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^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q Peretz, I., & Hyde, K. L. (2003). "What is specific to music processing? Insights from congenital amusia." [Review]. Trends in Cognitive Sciences, 7(8), 362-367.
^ I. Peretz; R. Zatorre, Brain organization for music processing., Annual Review of Psychology, vol. 56, pp. 89-114 (2005)
^ Hébert, S., Racette, A., Gagnon, L. & Peretz, I. (2003) Revisiting the dissociation between singing and speaking in expressive aphasia. Brain, vol. 126(8), pp. 1838-1850
^ Dorgueille, C. 1966. Introduction à l'étude des amusies. Unpublished doctoral dissertation, Université de la Sorbonne, Paris.
^ Sacks, Oliver. (2007). Musicophilia, New York: Random House. pp. 3-17, 187-258, 302-303.
^ Burkhard Maess, Stefan Koelsch, Thomas C. Gunter and Angela D. Friederici. "Musical syntax is processed in Broca’s area: an MEG study" (2001) Nature Publishing Group.
^ ^a ^b ^c ^d ^e http://amusia-brain.blogspot.com/2008/02/definition_25.html Hutchings, Tiffany, Seth Hayden, Mandy Politziner, and Erina Kainuma. "Amusia." Web log post. Amusia: Definition, Welcome to Amusia..., Congenital and Acquired Amusia, Neural Overview. 25 Feb. 2008. Web. 10 Oct. 2009.
^ Bautista, R., Ciampetti, M. (2003). Expressive Aprosody and Amusia as a Manifestation of Right Hemisphere Seizures. Epilepsia, 44(3), 466-467.
^ ^a ^b ^c Douglas, K. M., Bilkey, D.K., "Amusia is Associated with Deficits in Spatial Processing." Nature Neuroscience 10, 915-921 (2007)
^ Liu F, Patel AD, Fourcin A, Stewart L. (2010). Intonation processing in congenital amusia: discrimination, identification and imitation. Brain. 133(Pt 6):1682-93. doi:10.1093/brain/awq089 PMID 20418275
^ ^a ^b ^c Isabelle Peretz, Elvira Brattico, Miika Järvenpa, and Mari Tervaniemi. "The amusic brain: in tune, out of key, and unaware." (March 31, 2009). Brain: A Journal of Neurology [Article].
^ ^a ^b Ayotte, J., Peretz, I., & Hyde, K. (2002). "Congenital amusia - A group study of adults afflicted with a music-specific disorder." [Article]. Brain, 125, 238-251.
^ Peretz I, Champod AS, Hyde KL. Varieties of musical disorders. The Montreal battery of evaluation of amusia. Ann N Y Acad Sci 2003;999: 58–75.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ Peretz, I., Ayotte, J., Zatorre, R. J., Mehler, J., Ahad, P., Penhune, V. B., et al. (2002). "Congenital amusia: A disorder of fine-grained pitch discrimination." [Article]. Neuron, 33(2), 185-191.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Peretz, I., Cummings, S., & Dube, M. P. (2007). "The genetics of congenital amusia (tone deafness): A family-aggregation study." [Article]. American Journal of Human Genetics, 81(3), 582-588.
^ ^a ^b Hyde, K. L., & Peretz, I. (2004). "Brains that are out of tune but in time." [Article]. Psychological Science, 15(5), 356-360.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k Sarkamo, T., Tervaniemi, M., Soinila, S., Autti, T., Silvennoinen, H. M., Laine, M., et al. (2009). "Cognitive deficits associated with acquired amusia after stroke: A neuropsychological follow-up study." [Article]. Neuropsychologia, 47(12), 2642-2651.
^ Zatorre, R.J., Berlin, P. (2001). Spectral and temporal processing in human auditory cortex. Cerebral Cortex. 11:946-953
^ ^a ^b Ayotte, J., Peretz, I., Rousseau, I., Bard, C., Bojanowski, M. (2000). Patterns of music agnosia associated with middle cerebral artery infarcts. Brain. 123:1926-1938
^ Tramo, M., Shah, G.D., Braida, L.D. (2002). Functional role of auditory cortex in frequency processing and pitch perception. Journal of Neurophysiology. 87:122-139.
^ Di Pietro, M., Laganaro, M., Leeman, B., Schnider, A. (2004). Receptive amusia: temporal auditory deficit in a processional musician following a left temporo-parietal lesion. Neuropsychologia. 42:868-977.
^ Wilson, S.J., Pressing, J., Wales, R.J. (2002). Modeling rhythmic function in a musician post-stroke. Neuropsychologia. 40:1494-505.
^ Halsband, U., Tanji, J. Feund, H.J. (1993). The role of premotor cortex and the supplementary motor area in the temporal control of movement in man. Brain. 116:243-246.
^ Zatorre, R.J., Samson, S. (1991) Role of the right temporal neocortex in retention of pitch in auditory short-term memory. Brain. 114:2403-2417.
^ Gaab, N., Gaser, C., Zaehle, T., Jancke, L., Schlaug, G. (2003). Functional anatomy of pitch memory-an fMRI study with sparse temoral sampling. NeuroLmage. 19:1417-1426.
^ Zatorre, R.J., Halpern, R. (1993). Effect of unilateral temporal-lobe excision on percention and imagery of songs. Neuropsychologia. 31:221-32.
^ ^a ^b ^c Hyde, K. L., Zatorre, R. J., Griffiths, T. D., Lerch, J. P., & Peretz, I. (2006). "Morphometry of the amusic brain: a two-site study." [Article]. Brain, 129, 2562-2570.
^ Alossa, Nicoletta; Castelli, Lorys, "Amusia and Musical Functioning", Eur Neurol, Vol. 61, No. 5, pp. 269-277 (2009)
^ doi:10.1016/S0278-2626(02)00527-4. Johnson, Julene; Graziano, Amy, "August Knoblauch and amusia: A Nineteenth-century Cognitive Model of Music", (February 2003)
^ Foxton, J. M., Dean, J. L., Gee, R., Peretz, I., & Griffiths, T. D. (2004). "Characterization of deficits in pitch perception underlying 'tone deafness'." [Article]. Brain, 127, 801-810.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ Bella, S. D., Giguere, J. F., & Peretz, I. (2009). "Singing in congenital amusia." [Article]. Journal of the Acoustical Society of America, 126(1), 414-424.
^ ^a ^b ^c ^d http://brain.oxfordjournals.org/cgi/content/full/125/2/238I. Ayotte, Julie; Peretz, Isabelle; Hyde, Krista, Congenital Amusia., Brain, vol. 125 No. 2, pp. 238-251 (February 2002)
^ Peretz, Isabelle; Brattico, Elvira; Tervaniemi, Mari," Abnormal Electrical Brain Responses to Pitch in Congenital Amusia," Annals of Neurology, Vol. 58 (September 2002)
^ Hyde, Krista; Lerch, Jason; Zatorre, Robert J., "Cortical Thickness in Congenital Amusia: When Less Is Better Than More., The Journal of Neuroscience, Vol. 27(47) pp.13028-13032 (November 2007)
^ ^a ^b ^c http://www3.interscience.wiley.com/cgi-bin/fulltext/118867217/PDFSTART. Bautista, R.E., Ciampetti, M.Z., "Expressive Aprosody and Amusia as a Manifestation of Right Hemisphere Seizures.", Epilepsia, 44(3):466–467, 2003
^ Stewart, Lauren, "Pitch Fever", BBC Music Magazine, pp 36-38, (October 2005)
^ ^a ^b ^c Münte, Thomas (February 2002). "Brains out of Tune" (PDF). Nature 415: 589–590.

External links[edit]

PLab - Isabelle Peretz Laboratory
BRAMS - International Laboratory on Brain, Music and Sound Research
Oliver Sacks discussing Amusia
Review of the first documented case of congenital amusia
Delosis- Musical Listening Test

English Journal

Selective preservation of the beat in apperceptive music agnosia: A case study.

Baird AD1, Walker DG2, Biggs V2, Robinson GA3.
Cortex; a journal devoted to the study of the nervous system and behavior.Cortex.2014 Apr;53:27-33. doi: 10.1016/j.cortex.2014.01.005. Epub 2014 Jan 22.
INTRODUCTION: Music perception involves processing of melodic, temporal and emotional dimensions that have been found to dissociate in healthy individuals and after brain injury. Two components of the temporal dimension have been distinguished, namely rhythm and metre. We describe an 18 year old mal
PMID 24561388

The impact of depression on musical ability.

Reker P1, Domschke K2, Zwanzger P2, Evers S3.
Journal of affective disorders.J Affect Disord.2014 Mar;156:150-5. doi: 10.1016/j.jad.2013.12.010. Epub 2013 Dec 16.
BACKGROUND: While there is sustained effort to refine the models and to further decrypt the neuronal underpinnings of cerebral music perception, empirical investigations on the associations of music perception with diagnoses others than focal brain damage need to be amplified.METHODS: In the present
PMID 24370266

Impaired musical ability in people with schizophrenia.

Hatada S1, Sawada K2, Akamatsu M1, Doi E3, Minese M3, Yamashita M4, Thornton AE5, Honer WG6, Inoue S1.
Journal of psychiatry & neuroscience : JPN.J Psychiatry Neurosci.2014 Mar;39(2):118-26.
BACKGROUND: Assessment of the musical ability of people with schizophrenia has attracted little interest despite the diverse and substantive findings of impairments in sound perception and processing and the therapeutic effect of music in people with the illness. The present study investigated the m
PMID 24119791

Japanese Journal

音楽の脳内過程についての神経心理学的検討(音楽の人間科学,2010年度第2回フォーラム)

佐藤正之
基礎心理学研究 30(1), 115-120, 2011-09-30
… The case 2 had infarction of bilateral temporal lobes, and revealed word deafness, environmental sound agnosia, and receptive and expressive amusia. …
NAID 110008790333

招待講演聴覚失認と失音楽--聴皮質損傷と認知

進藤美津子
聴覚研究会資料 40(4), 287-292, 2010-05-14
NAID 40017142772

尺八譜と五線譜の読み書きに乖離を呈した失音楽症の1例

出田和泉,種村純,岸本寿男
高次脳機能研究 : 日本高次脳機能障害学会誌 = Higher brain function research 28(4), 404-415, 2008-12-31
アマチュア尺八奏者でピアノの訓練経験もあったKM は，五線譜および尺八譜の読み書きが可能な二楽譜使用者であった。くも膜下出血後尺八譜の読み書き障害は軽度だったが，五線譜の読み書き能力は顕著に障害され，既知のメロディーを聴いて書譜する課題や音読課題では，五線譜と尺八譜の成績が乖離した。楽曲を正確に記譜する五線譜に対し，尺八譜は楽器の操作法を仮名文字で表記する奏法譜である。西洋音楽と異なり邦楽には …
NAID 10027845360