aminoglycoside-modifying enzyme

アミノグリコシド修飾酵素

WordNet

1. any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

PrepTutorEJDIC

1. 酵素

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• 1. アミノグリコシド aminoglycosides
• 2. アミノグリコシドによる腎毒性の症状および危険因子 manifestations of and risk factors for aminoglycoside nephrotoxicity
• 3. 腸球菌における抗菌薬耐性の機構 mechanisms of antibiotic resistance in enterococci
• 4. アミノグリコシドの腎毒性および聴覚毒性の病因および予防 pathogenesis and prevention of aminoglycoside nephrotoxicity and ototoxicity
• 5. マクロライド系剤、アミノグリコシド、テトラサイクリン、クリンダマイシン、およびメトロニダゾールに対する過敏反応 hypersensitivity reactions to macrolides aminoglycosides tetracyclines clindamycin and metronidazole

English Journal

• Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study.

• Kaplan E1, Guichou JF2, Chaloin L1, Kunzelmann S3, Leban N1, Serpersu EH4, Lionne C5.
• Biochimica et biophysica acta.Biochim Biophys Acta.2016 Apr;1860(4):802-13. doi: 10.1016/j.bbagen.2016.01.016. Epub 2016 Jan 21.
• BACKGROUND: Aminoglycoside O-phosphotransferases make up a large class of bacterial enzymes that is widely distributed among pathogens and confer a high resistance to several clinically used aminoglycoside antibiotics. Aminoglycoside 2″-phosphotransferase IVa, APH(2″)-IVa, is an important member
• PMID 26802312

• Origin in Acinetobacter gyllenbergii and dissemination of aminoglycoside-modifying enzyme AAC(6')-Ih.

• Yoon EJ1, Goussard S1, Nemec A2, Lambert T3, Courvalin P4, Grillot-Courvalin C1.
• The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2016 Mar;71(3):601-6. doi: 10.1093/jac/dkv390. Epub 2015 Dec 7.
• OBJECTIVES: The aac(6')-Ih gene encoding aminoglycoside 6'-N-acetyltransferase type I subtype h [AAC(6')-Ih] is plasmid-borne in Acinetobacter baumannii where it confers high-level amikacin resistance, but its origin remains unknown. We searched for the gene in the genomes of a collection of 133 Aci
• PMID 26645270

• [Characterisation of carbapenem-resistance mechanisms in clinical Pseudomonas aeruginosa isolates recovered in a Spanish hospital].

• Estepa V1, Rojo-Bezares B2, Azcona-Gutiérrez JM3, Olarte I3, Torres C4, Sáenz Y5.
• Enfermedades infecciosas y microbiologia clinica.Enferm Infecc Microbiol Clin.2016 Feb 8. pii: S0213-005X(16)00031-8. doi: 10.1016/j.eimc.2015.12.014. [Epub ahead of print]
• INTRODUCTION: Carbapenems are the beta-lactam antibiotics with the best spectrum of activity in the treatment of Pseudomonas aeruginosa infections. The objective of this study was to molecularly characterise a collection of carbapenem-resistant P. aeruginosa isolates (PARC).METHODS: A total of 85 PA
• PMID 26869071

Japanese Journal

• 血液分離 Enterococcus spp. のアミノ配糖体系薬高度耐性株の性状

• 金山 明子,高橋 裕子,内野 卯津樹,長谷川 美幸,佐藤 弓枝,小林 寅〓,金子 明寛
• 日本化学療法学会雜誌 = Japanese journal of chemotherapy 53(3), 177-182, 2005-03-25
• NAID 10015574089

• 血液分離Ｅｎｔｅｒｏｃｏｃｃｕｓ　ｓｐｐ．のアミノ配糖体系薬高度耐性株の性状

• 金山 明子,高橋 裕子,内野 卯津樹,長谷川 美幸,佐藤 弓枝,小林 寅哲,金子 明寛
• 日本化学療法学会雑誌 53(3), 177-182, 2005
• … 今回は血液由来<I>Enterococcus</I>におけるアミノ配糖体高度耐性 (highlevel aminoglycoside-resistant: HLAR) 株の薬剤感受性三および耐性遺伝子について検討した。 …
• NAID 130004102714

• Characterization of a Bifunctional Aminoglycoside-Modifying Enzyme with Novel Substrate Specificity and Its Gene from a Clinical Isolate of Methicillin-Resistant Staphylococcus aureus with High Arbekacin Resistance

• ISHINO KEIKO,ISHIKAWA JUN,IKEDA YOKO,HOTTA KUNIMOTO
• Journal of antibiotics = An International Journal Devoted to Research on Bioactive Microbial Products 57(10), 679-686, 2004-10-25
• NAID 10013726971

Related Links

• Aminoglycoside modifying enzymes - PubMed

Aminoglycoside modifying enzymes. Aminoglycosides have been an essential component of the armamentarium in the treatment of life-threatening infections. Unfortunately, their efficacy has been reduced by the surge and dissemination of resistance.

• Aminoglycoside modifying enzymes - ScienceDirect

Aminoglycoside modifying enzymes Aminoglycoside modifying enzymes catalyze the modification at –OH or –NH2groups of the 2-deoxystreptamine nucleus or the sugar moieties and can be acetyltransferases (AACs), nucleotidyltranferases (ANTs), or phosphotransferases (APHs) (Fig. 1).

• Aminoglycoside-modifying enzymes - ScienceDirect

Aminoglycoside acetyltransferases AACs are acetylCoA-dependent acyltransferases that primarily modify amino groups (N -acetyltransferases). However, O -acetyltransfer was recently detected using the acetyltransferase domain of the bifunctional enzyme AAC (6′)-APH (2″) [11 •].

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★リンクテーブル★

リンク元	「AME」「アミノグリコシド修飾酵素」
拡張検索	「aminoglycoside-modifying enzymes」
関連記事	「aminoglycoside」「aminoglycosides」

「AME」

　　[★] アミノグリコシド修飾酵素 aminoglycoside-modifying enzyme

「アミノグリコシド修飾酵素」

　　[★]

英

aminoglycoside-modifying enzyme, AME

「aminoglycoside-modifying enzymes」

　　[★] アミノグリコシド修飾酵素

「aminoglycoside」

　　[★] アミノグリコシド系抗菌薬

「aminoglycosides」

　　[★] アミノグリコシド系抗菌薬