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1. 不安定ヘモグロビン変異体 unstable hemoglobin variants
2. 膣炎症状が認められる女性の評価 evaluation of women with symptoms of vaginitis
3. 末期腎不全患者における弁膜症 valvular heart disease in patients with end stage renal disease
4. 幼児および小児の孤立性心室中隔欠損の管理 management of isolated ventricular septal defects in infants and children
5. 幼児および小児における孤立性心室中隔欠損の病態生理および臨床的特徴 pathophysiology and clinical features of isolated ventricular septal defects in infants and children

Assaying Ceramide Synthase Activity In Vitro and in Living Cells Using Liquid Chromatography-Mass Spectrometry.

Lim XY1, Pickford R2, Don AS3.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1376:11-22. doi: 10.1007/978-1-4939-3170-5_2.
Sphingolipids are one the major lipid families in eukaryotes, incorporating a diverse array of structural and signaling lipids such as sphingomyelin and gangliosides. The core lipid component for all complex sphingolipids is ceramide, a diacyl lipid consisting of a variable length fatty acid linked
PMID 26552671

Synthesis of some new amide-linked bipyrazoles and their evaluation as anti-inflammatory and analgesic agents.

Faour WH1, Mroueh M2, Daher CF3, Elbayaa RY4,5, Ragab HM4, Ghoneim AI6,7, El-Mallah AI8, Ashour HM4.
Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2015 Oct 20:1-16. [Epub ahead of print]
Four series of new bipyrazoles comprising the N-phenylpyrazole scaffold linked to polysubstituted pyrazoles or to antipyrine moiety through different amide linkages were synthesized. The synthesized compounds were evaluated for their anti-inflammatory and analgesic activities. In vitro COX-1/COX-2 i
PMID 26482802

Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis.

Park IH1, Venable JD1, Steckler C1,2, Cellitti SE1, Lesley SA1,3,2, Spraggon G1, Brock A1.
Journal of chemical information and modeling.J Chem Inf Model.2015 Sep 28;55(9):1914-25. doi: 10.1021/acs.jcim.5b00185. Epub 2015 Aug 20.
Hydrogen exchange (HX) studies have provided critical insight into our understanding of protein folding, structure, and dynamics. More recently, hydrogen exchange mass spectrometry (HX-MS) has become a widely applicable tool for HX studies. The interpretation of the wealth of data generated by HX-MS
PMID 26241692

Synthesis and Evaluation of Fatty Acid Amides on the N-Oleoylethanolamide-Like Activation of Peroxisome Proliferator Activated Receptor α

Takao Koichi,Noguchi Kaori,Hashimoto Yosuke,Shirahata Akira,Sugita Yoshiaki
Chemical and Pharmaceutical Bulletin 63(4), 278-285, 2015
… The mRNAs of the PPAR-α downstream genes, carnitine-palmitoyltransferase-1 and mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase, were determined by real-time reverse transcription-polymerase chain reaction (RT-PCR) as PPAR-α agonistic activities. …
NAID 130005061431

Maruoka Shintaro,Lee Woo Cheol,Kamo Masayuki [他],KUDO Norio,NAGATA Koji,TANOKURA Masaru
Proceedings of the Japan Academy, Series B 81(10), 459-462, 2005
… The glutamine amide nitrogen is utilized for the biosynthesis of a variety of molecules such as amino acids, coenzymes, antibiotics, purine and pyrimidine nucleotides, and glucosamine. … coli guanosine 5'-monophosphate (GMP) synthase and Sulfolobus solfataricus anthranilate synthase, respectively. …
NAID 130000093819

庄司満,山口新平,向山貴祐,五東弘昭,山口潤一郎,浅見行弘,掛谷秀昭,長田裕之,林雄二郎
天然有機化合物討論会講演要旨集 (45), 79-84, 2003-09-01
… Pseurotin A, isolated in 1976, inhibits chitin synthase and also induces cell differentiation of PC12 cells, while azaspirene, isolated in 2002 by Kakeya and Osada et al., is an angiogenesis inhibitor, and attracted much attention as a lead of a drug for the treatment of cancer. … The aldol condensation proceeds smoothly between a side chain aldehyde and the ketone containing functionalized γ-lactam moiety without protection of tert-alcohol and amide functionalities. …
NAID 110006682273