エナメル芽細胞
WordNet
- a cell from which tooth enamel develops
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/16 14:45:57」(JST)
[Wiki en表示]
| Ameloblast |
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A developing tooth with odontoblasts marked.
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The cervical loop area: (1) dental follicle cells, (2) dental mesenchyme, (3) Odontoblasts, (4) Dentin, (5) stellate reticulum, (6) outer enamel epithelium, (7)inner enamel epithelium, (8) ameloblasts, (9) enamel.
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| Details |
| Identifiers |
| Latin |
ameloblastus |
| Code |
TE E05.04.1.1.2.3.20 |
| Anatomical terminology
[edit on Wikidata]
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Ameloblasts are cells present only during tooth development that deposit tooth enamel, which is the hard outermost layer of the tooth forming the surface of the crown.
Contents
- 1 Origin
- 1.1 Life cycle of ameloblasts [2]
- 2 Function
- 3 Structure
- 4 Pathophysiology
- 5 References
- 6 External links
- 7 See also
Origin
Ameloblasts are derived from oral epithelium tissue of ectodermal origin. Their differentiation from preameloblasts (whose origin is from inner enamel epithelium) is a result of signaling from the ectomesenchymal cells of the dental papilla.
The ameloblasts will only become fully functional after the first layer of dentin (predentin) has been formed by odontoblasts. The cells are part of the reduced enamel epithelium after enamel maturation and then are subsequently lost during tooth eruption.[1]
Life cycle of ameloblasts [2]
The life cycle of ameloblasts consists of six stages :
- Morphogenic stage
- Organizing stage
- Formative (secretory) stage (Tomes' processes appear)
- Maturative stage
- Protective stage
- Desmolytic stage
The murine ALC cell line is of ameloblastic origin.[3]
Function
Ameloblasts are cells which secrete the enamel proteins enamelin and amelogenin which will later mineralize to form enamel, the hardest substance in the human body.[4] Ameloblasts control ionic and organic compositions of enamel. It is theorized that a circadian clock (24-hour) probably regulates enamel production on a daily cycle by the ameloblasts (similar to osteoblasts in production of bone tissue).[5][6] Ameloblasts adjust their secretory and resorptive activities to maintain favorable conditions for biomineralization.[7]
Structure
Each ameloblast is a columnar cell approximately 4 micrometers in diameter, 40 micrometers in length and is hexagonal in cross section. The secretory end of the ameloblast ends in a six-sided pyramid-like projection known as the Tomes' process. The angulation of the Tomes' process is significant in the orientation of enamel rods, the basic unit of tooth enamel.
Pathophysiology
These cells are sensitive to their environment. One common example is illustrated by the neonatal line, a pronounced incremental line of Retzius found in the primary teeth and in the larger cusps of the permanent first molars, showing a disruption in enamel production when the person is born.[8] High fevers in childhood are also an example of bodily stressors causing interruptions in enamel production.
Another possible example of this sensitivity (stress response pathway activation) may be the development of dental fluorosis after childhood exposure (between the ages of 2 to 8 years old) to excess fluoride, an elemental agent used to increase enamel hardness and prevent dental caries.[9]
References
- ^ Ten Cate's Oral Histology, Nanci, Elsevier, 2013, page 103
- ^ Ten Cate's Oral Histology, Nanci, Elsevier, 2013, page 153
- ^ Takahashi, Satomi; Kawashima, Nobuyuki; Sakamoto, Kei; Nakata, Akira; Kameda, Takashi; Sugiyama, Toshihiro; Katsube, Ken-Ichi; Suda, Hideaki (2007). "Differentiation of an ameloblast-lineage cell line (ALC) is induced by Sonic hedgehog signaling". Biochemical and Biophysical Research Communications 353 (2): 405–11. doi:10.1016/j.bbrc.2006.12.053. PMID 17188245.
- ^ Gallon V, Chen L, Yang X, Moradian-Oldak J. Localization and quantitative co-localization of enamelin with amelogenin. J Struct Biol. 2013 Apr
- ^ Sehic A, Nirvani M, Risnes S. Incremental lines in mouse molar enamel. Arch Oral Biol. 2013
- ^ Zheng L, Seon YJ, Circadian rhythms regulate amelogenesis. Bone. 2013
- ^ Ten Cate's Oral Histology, Nanci, Elsevier, 2013, page 147
- ^ Illustrated Dental Embryology, Histology, and Anatomy, Bath-Balogh and Fehrenbach, Elsevier, 2011, page 151
- ^ Megan L. Sierant and John D. Bartlett, Stress Response Pathways in Ameloblasts: Implications for Amelogenesis and Dental Fluorosis, Cells 2012, 1, 631-645 at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671616/
External links
- Regulation of Dental Enamel Shape and Hardness, Journal of Dental Research, 2010, Simmer, et al., at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086535/
See also
- Tooth development
- Enamel
- Dentin
- Odontoblast
- Ameloblastoma
- Ameloblastin
- Amelogenesis imperfecta
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Tooth development
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| Precursor cells |
- Odontoblast
- Ameloblast
- Cementoblast
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| General |
- Dentition
- Teething
- Tooth eruption
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| Other |
- Dental papilla
- Epithelial root sheath
- Epithelial cell rests of Malassez
- Dental lamina
- Enamel organ
- Outer enamel epithelium
- Inner enamel epithelium
- Stellate reticulum
- Stratum intermedium
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| Pulp occlusion |
- Canalis amelodentineus
- Fovea enamelea
- Fovea dentinea
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Cells in humans derived from ectoderm
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| Surface ectoderm |
| Skin |
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| Anterior pituitary |
- Gonadotrope
- Corticotrope
- Thyrotrope
- Somatotrope
- Lactotroph
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| Neural crest |
| Peripheral nervous system |
- Neuron
- Glia
- Schwann cell
- Satellite glial cell
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| Neuroendocrine system |
- Chromaffin cell
- Parafollicular cell
- Glomus cell
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| Skin |
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| Teeth |
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| Eyes |
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| Neural tube |
| Central nervous system |
- Neuron
- Glia (Oligodendrocyte
- Astrocyte)
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| Ependyma |
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| Pineal gland |
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UpToDate Contents
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- 1. 歯性感染症の疫学、病因、および臨床症状 epidemiology pathogenesis and clinical manifestations of odontogenic infections
- 2. 歯の解剖学的構造および発達 anatomy and development of the teeth
- 3. 歯の発達障害 developmental defects of the teeth
English Journal
- Gastrin-releasing peptide expression and its effect on the calcification of developing mouse incisor.
- Lee DJ1, Jin C, Kim EJ, Lee JM, Jung HS.
- Histochemistry and cell biology.Histochem Cell Biol.2015 Sep;144(3):273-9. doi: 10.1007/s00418-015-1335-1. Epub 2015 Jul 1.
- Gastrin-releasing peptide (GRP) is considered to be one of the cancer growth factors. This peptide's receptor (GRPR) is known as a G protein-coupled receptor, regulating intracellular calcium storage and releasing signals. This study is the first to investigate the function of GRP during mouse incis
- PMID 26126650
- Tooth enamel protein amelogenin binds to ameloblast cell membrane-mimicking vesicles via its N-terminus.
- Lokappa SB1, Chandrababu KB1, Moradian-Oldak J2.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Aug 28;464(3):956-61. doi: 10.1016/j.bbrc.2015.07.082. Epub 2015 Jul 17.
- We have recently reported that the extracellular enamel protein amelogenin has affinity to interact with phospholipids and proposed that such interactions may play key roles in enamel biomineralization as well as reported amelogenin signaling activities. Here, in order to identify the liposome-inter
- PMID 26188506
- MicroRNA 224 Regulates Ion Transporter Expression in Ameloblasts To Coordinate Enamel Mineralization.
- Fan Y1, Zhou Y1, Zhou X1, Sun F1, Gao B1, Wan M1, Zhou X1, Sun J1, Xu X2, Cheng L2, Crane J3, Zheng L4.
- Molecular and cellular biology.Mol Cell Biol.2015 Aug 15;35(16):2875-90. doi: 10.1128/MCB.01266-14. Epub 2015 Jun 8.
- Enamel mineralization is accompanied by the release of protons into the extracellular matrix, which is buffered to regulate the pH value in the local microenvironment. The present study aimed to investigate the role of microRNA 224 (miR-224) as a regulator of SLC4A4 and CFTR, encoding the key buffer
- PMID 26055330
Japanese Journal
- Localization of Core Planar Cell Polarity Proteins, PRICKLEs, in Ameloblasts of Rat Incisors: Possible Regulation of Enamel Rod Decussation
- Nishikawa Sumio,Kawamoto Tadafumi
- ACTA HISTOCHEMICA ET CYTOCHEMICA 48(2), 37-45, 2015
- To confirm the possible involvement of planar cell polarity proteins in odontogenesis, one group of core proteins, PRICKLE1, PRICKLE2, PRICKLE3, and PRICKLE4, was examined in enamel epithelial cells a …
- NAID 130005068295
- Localization of Core Planar Cell Polarity Proteins, PRICKLEs, in Ameloblasts of Rat Incisors: Possible Regulation of Enamel Rod Decussation
- Nishikawa Sumio,Kawamoto Tadafumi
- ACTA HISTOCHEMICA ET CYTOCHEMICA advpub(0), 2015
- To confirm the possible involvement of planar cell polarity proteins in odontogenesis, one group of core proteins, PRICKLE1, PRICKLE2, PRICKLE3, and PRICKLE4, was examined in enamel epithelial cells a …
- NAID 130005065243
- Sp6 regulation of Rock1 promoter activity in dental epithelial cells
- Dwi Yanuaryska Ryna,Miyoshi Keiko,Adiningrat Arya,Horiguchi Taigo,Tanimura Ayako,Hagita Hiroko,Noma Takafumi
- The Journal of Medical Investigation 61(3.4), 306-317, 2014
- … Sp6 is a transcription factor of the SP/KLF family and an indispensable regulator of the morphological dynamics of ameloblast differentiation during tooth development. … We have previously identified one of the Sp6 downstream genes, Rock1, which is involved in ameloblast polarization. …
- NAID 130004822736
Related Links
- ameloblast [ah-mel´o-blast] a cell that takes part in forming dental enamel. am·e·lo·blast (am'ĕ-lō-blast), One of the columnar epithelial cells of the inner layer of the enamel organ of a developing tooth, involved with the formation of ...
- ameloblastに関連した研究者の検索結果 日本の研究.com > 研究者検索 > 研究者検索結果 研究者検索 研究課題検索 記事検索 検索 空白除去 詳細検索 フリーワード 研究者名 完全一致 所属 事業区分 事業区分選択 ...
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