アムシノニド
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/21 16:52:44」(JST)
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Amcinonide
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Systematic (IUPAC) name |
2-[(1S,2S,4R,8S,9S,11S,12R,13S)-12'-fluoro-11'-hydroxy-9',13'-dimethyl-16'-oxo-5',7'-dioxaspiro[cyclopentane-1,6'-pentacyclo[10.8.0.02,9.04,8.013,18]icosane]-14',17'-dien-8'-yl]-2-oxoethyl acetate |
Clinical data |
Trade names |
Cyclocort |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
Pregnancy cat. |
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Legal status |
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Routes |
Topical |
Identifiers |
CAS number |
51022-69-6 Y |
ATC code |
D07AC11 |
PubChem |
CID 443958 |
DrugBank |
DB00288 |
ChemSpider |
392009 Y |
UNII |
423W026MA9 Y |
KEGG |
D01387 Y |
ChEBI |
CHEBI:31199 Y |
ChEMBL |
CHEMBL1200732 N |
Chemical data |
Formula |
C28H35FO7 |
Mol. mass |
502.572 g/mol |
SMILES
- O=C(OCC(=O)[C@]45OC6(O[C@@H]5C[C@@H]2[C@@]4(C[C@H](O)[C@]3(F)[C@]/1(/C=C\C(=O)\C=C\1CC[C@@H]23)C)C)CCCC6)C
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InChI
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InChI=1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1 Y
Key:ILKJAFIWWBXGDU-MOGDOJJUSA-N Y
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N (what is this?) (verify) |
Amcinonide (trade name Cyclocort) is a topical glucocorticoid used to treat itching, redness and swelling associated with several dermatologic conditions such as atopic dermatitis and allergic contact dermatitis.[1][2]
References
- ^ Drugs.com: Amcinonide topical
- ^ Bickers, D. R. (1984). "A comparative study of amcinonide and halcinonide in the treatment of eczematous dermatitis". Cutis; cutaneous medicine for the practitioner 34 (2): 190–194. PMID 6383735. edit
Corticosteroids – glucocorticoids and mineralocorticoids (H02)
(also A07EA, C05AA, D07, D10AA, R01AD, R03BA, S01BA, S02B, and S03B)
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Mineralocorticoids
(3-one, 4-ene,
no FG at 16) |
- Pregnenedione: ALDOSTERONE
- 11-DEOXYCORTICOSTERONE
- HALOGENATED AT 9: Fludrocortisone
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Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy) |
Pregnene
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Pregnenedione
(+20-one)
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- HYDROCORTISONE/CORTISOL# (Hydrocortisone aceponate
- Hydrocortisone buteprate
- Hydrocortisone butyrate)
- Budesonide
- Ciclesonide
- Deflazacort
- Medrysone
- Tixocortol
- HALOGENATED AT 6: Cloprednol
- HALOGENATED, WITH FG AT 16: Halcinonide
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Pregnadiene (+1-ene)
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- Rimexolone
- HALOGENATED, WITH FG AT 16: Flunisolide
- Triamcinolone
- Amcinonide
- Fluocinolone acetonide (Fluocinonide)
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Pregnadienediol
(+21-hydroxy)
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- Prednisone (Meprednisone)
- HALOGENATED AT 9: Fluorometholone
- HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone
- Diflucortolone
- Fluocortin)
- Desoximetasone
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Pregnadienetriol
(+11-hydroxy)
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- Prednisolone# (Methylprednisolone
- Methylprednisolone aceponate
- Prednicarbate
- Prednylidene)
- Desonide
- HALOGENATED: Fluprednisolone (Difluprednate
- Fluperolone)
- HALOGENATED, WITH FG AT 16: Dexamethasone#
- Betamethasone (Clobetasol
- Clobetasone
- Diflorasone
- Halometasone
- Ulobetasol)
- Beclometasone
- Paramethasone
- Alclometasone
- Fluclorolone acetonide
- Flumetasone
- Fluprednidene
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Pregnatriene
(+2-ene)
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Androstene
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- HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate
- Fluticasone furoate)
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Other/ungrouped
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- HALOGENATED: Loteprednol
- HALOGENATED, WITH FG AT 16: Fludroxycortide
- Formocortal
- Mometasone furoate
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Aldosterone antagonists |
- Spironolactone
- Eplerenone
- Potassium canrenoate
- Canrenone
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Synthesis modifiers |
- Trilostane
- Carbenoxolone
- Aminoglutethimide
- Metyrapone
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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noco (d)/cong/tumr, sysi/epon
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proc, drug (A10/H1/H2/H3/H5)
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English Journal
- Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor.
- Hong J1, Kim BK, Lim H, Lee S, Lee SJ.
- Immunopharmacology and immunotoxicology.Immunopharmacol Immunotoxicol.2012 Dec;34(6):912-8. doi: 10.3109/08923973.2012.671332. Epub 2012 May 3.
- Recent studies show that necrotic neuronal cells (NNC) activate microglia, thereby leading to neuronal cell death. This suggests that chemicals that inhibit microglia activation may be used as neuroprotective drugs. In this context, we screened a chemical library for inhibitors of microglia activati
- PMID 22551518
- Contact allergy to topical corticosteroids--results from the IVDK and epidemiological risk assessment.
- Uter W1, de Pádua CM, Pfahlberg A, Nink K, Schnuch A, Lessmann H.
- Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.J Dtsch Dermatol Ges.2009 Jan;7(1):34-41, 34-42. doi: 10.1111/j.1610-0387.2008.06844.x. Epub 2008 Aug 28.
- BACKGROUND: Contact allergy (CA) to topical corticosteroids (CS) is relatively rare; however, current data from Germany are not available. Furthermore, valid risk assessment needs to take into account of the actual exposure to CS in the population.PATIENTS AND METHODS: The reaction profile of 9 CS i
- PMID 18761609
- Allergic contact dermatitis to topical drugs--epidemiological risk assessment.
- de Pádua CA1, Schnuch A, Nink K, Pfahlberg A, Uter W.
- Pharmacoepidemiology and drug safety.Pharmacoepidemiol Drug Saf.2008 Aug;17(8):813-21. doi: 10.1002/pds.1588.
- PURPOSE: Estimation of the population-based relative incidence (RI) of contact sensitization to a set of topical drug allergens (cases/100,000 defined daily doses (DDDs) per year) (1995-2004) and comparison of the RI for drugs with a similar therapeutic scope.METHODS: Clinical data regarding the fre
- PMID 18383004
Japanese Journal
- A multicenter survey of patch-testing with Japanese standard series, topical steroid preparations (budesonide, amcinonide and hydrocortisone butyrate) and tin chloride (0.5%, 1.0% and 2.0% pet) in 1997
- MITSUYA Kaoru
- Environmental dermatology : the official journal of the Japanese Society for Contact Dermatitis 6(4), 199-208, 1999-10-01
- NAID 10023904805
- A multicenter survey of patch-testing with Japanese standard series, topical steroid preparations (budesonide, amcinonide and hydrocortisone butyrate) and tin chloride (0.5%, 1.0% and 2.0% pet) in 1997
- Allergic contact dermatitis from amcinonide
Related Links
- 15 Sep 2008 ... Learn about the prescription medication Amcinonide Cream (Amcinonide Cream, Ointment), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling.
- Amcinonide (trade name Cyclocort) is a topical glucocorticoid used to treat itching, redness and swelling associated with several dermatologic conditions such as atopic dermatitis and allergic contact dermatitis.
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