Journal of cell science.J Cell Sci.2015 Nov 2. pii: jcs.180786. [Epub ahead of print]
Although it is generally accepted that chromatin containing the histone H3 variant CENP-A is an epigenetic mark maintaining centromere identity, the pathways leading to the formation and maintenance of centromere chromatin remain unclear. We previously generated human artificial chromosomes (HACs) w
The centromere/kinetochore interaction is responsible for the pairing and segregation of replicated chromosomes in eukaryotes. Centromere DNA is portrayed as scarcely conserved, repetitive in nature, quickly evolving and protein-binding competent. Among primates, the major class of centromeric DNA i
Archives of gynecology and obstetrics.Arch Gynecol Obstet.2015 Jul 30. [Epub ahead of print]
PURPOSE: Evaluation of DNA integrity is an important test, possessing greater diagnostic and prognostic significance for couples requiring assisted reproduction. In this study, we evaluate the levels of DNA damage in infertile patients with varicocele with respect to fertile males by the sperm chrom
Sensitive and Rapid Detection of Centromeric Alphoid DNA in Human Metaphase Chromosomes by PNA Fluorescence In Situ Hybridization and Its Application to Biological Radiation Dosimetry
Large artery diseases with concomitant artherothrombotic risk factors were more frequent in VB stroke patients with prior TNA compared to those without.(大血管疾患はTNAがなかった患者よりTNAが先行した椎骨脳底梗塞患者でよくありがちである/よく見られる)